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| 1 | 高剂量利福平、莫西沙星和SQ109治疗肺结核:一项多组别、多阶段的随机对照试验显示文摘背景 结核病是世界传染病死亡的第一杀手,目前结核病治疗仍需要至少6个月的疗程,本临床试验旨在研究更短,更安全的敏感性结核病治疗方案. | Boeree MJ Heinrich N Aarnoutse R 申晓娜 孙勤 | 2017 | 中国防痨杂志2017，39，7： | 23 |
| 2 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 3 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 4 | Peroral Endoscopic Myotomy for the Treatment of Achalasia: An International Prospective Multicenter Study显示文摘 | Daniel Von Renteln Karl–Hermann Fuchs Paul Fockens Peter Bauerfeind Melina C. Vassiliou Yuki B. Werner Gerald Fried Wolfram Breithaupt Henriette Heinrich Albert J. Bredenoord Jan F. Kersten Tessa Verlaan Michael Trevisonno Thomas R?sch | 2013 | Gastroenterology2013，，2： | 2 |
| 5 | Losartan inhibits cellular uptake of oxidized LDL by monocyte-macrophages from hypercholesterolemic patients 显示文摘 | Hayek T Aviram M Heinrich R | 2000 | Biochem Biophys Res Commun2000，273，2： | 1 |
| 6 | Calibration of electrostatic discharge generators and results of an international comparison显示文摘 | Kurt H Heinrich R Ulrich H | 2001 | IEEE Trans on Instrumentation and Measurement2001，50，2： | 1 |
| 7 | Association of hypertensive status and its drug treatment with lipid and haemostatic factors in middle-aged men: the PRIME study显示文摘 | Junker R Heinrich J Schulte H | 2000 | J Hum Hypert2000，14，： | 1 |
| 8 | S3 Guideline: Sedation for gastrointestinal endoscopy 2008显示文摘 | A. Riphaus T. Wehrmann B. Weber J. Arnold U. Beilenhoff H. Bitter S. von Delius D. Domagk A. Ehlers S. Faiss D. Hartmann W. Heinrichs M.-L. Hermans C. Hofmann S. In der Smitten M. Jung G. K?hler M. Kraus J. Martin A. Meining J. Radke T. R?sch H. Seifert A | 2009 | Endoscopy2009，，09： | 1 |
| 9 | Numerical Simulation of Partial Discharge Propagation in Cable Joints Using the Finite Difference Time Domain Method 显示文摘 | POMMERENKE D JOBAVA R HEINRICH R | 2008 | IEEE Electrical Insulation Magazine2008，18，6： | 1 |
| 10 | Angiotensin Ⅱ ahterogenicity in apolipoprotein E deficient mice is associated with increased cellular cholesterol biosynthesis 显示文摘 | Keidar S Attias J Heinrich R | 1999 | Atherosclerosis1999，146，2： | 1 |
| 11 | C-reactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris显示文摘 | Tataru MC Heinrich J Junker R | 2000 | Eur Heart J2000，21，12： | 1 |
| 12 | LDPE/Mg- Al layered double hydroxide nano-composite: Thermal and flammability properties 显示文摘 | Costa F R Wagenknecht U Heinrich G | 2007 | Polymer Degradation and Stability2007，92，10： | 1 |
| 13 | Arsenic species excretion after controlled seafood consumption 显示文摘 | Heinrich R R Mindt P S Szadkowski D | 2002 | J Chromatogr(B)2002，778，： | 1 |
| 14 | C-Reactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris显示文摘 | Heinrich J Junker R | 2000 | Eur Heart J2000，21，： | 1 |
| 15 | Fuzzy linear programming and applications显示文摘 | Heinrich R | 1996 | European Journal of Operational Research1996，92，3： | 1 |
| 16 | Association ofvariables of coagulation,fibrinolysis and acute-phase with atherosclerosis in coronary and peripheral arteries and those arteries supplying 显示文摘 | Heinrich J Schulte H Schonfeld R | 1995 | the brain Thromb Haemost1995，73，： | 1 |
| 17 | Greenhouse techniques to identify field resistance to the brown planthopper,Nilaparvata lugens ( Stal ) ( Homoptera: Delphacidae ), in rice cultivars 显示文摘 | Velusamy R Heinrichs E A Medrano F G | 1986 | Crop Protection1986，5，5： | 1 |
| 18 | C reactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris显示文摘 | Heinrich J Junker R | 2000 | Eur heart J2000，21，： | 1 |
| 19 | Association of variables of coagula-Tion,fibrinolysis and acute-phase with atherosclerosis in coronary and peripheral arteries and those arteries supplying the brain显示文摘 | Heinrich J Schulte H Schonfeld R | 1995 | Thromb Haemost1995，74，3： | 1 |
| 20 | Association of variables of coahulation, ~rbrinolysis and acute-phase with atherosclerosis in coronary and peripheral arteries and those arteries supplying the brain 显示文摘 | HEINRICH J SCHULTI H SCHONFELD R | 1997 | Thromb Haemostas1997，73，： | 1 |
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