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| 1 | Sperm DNA damage and its clinical relevance in assessingreproductive outcome显示文摘The routine examination of semen, which assesses sperm concentration, percentage motility and morphology,does not identify subtle defects in sperm chromatin architecture. The focus on the genomic integrity of the male gamete has intensified recently due to the growing concern that genetic diseases may be transmitted via assisted reproductive techniques (ART). Accordingly, the intent of this review is to describe the details of the informationpertaining to mitochondfial/nuclear sperm DNA damage with an emphasis on its clinical significance and its relationship with male infertility. Assessment of sperm DNA damage appears to be a potential tool for evaluating semen samples prior to their use in ART. Testing DNA integrity may help select spermatozoa with intact DNA or with the least amount of DNA damage for use in assisted conception. In turn, this may alleviate the financial, social and emotional problems associated with failed ART attempts. | R. K. Sharma T. Said A. Agarwal | 2004 | Asian Journal of Andrology2004，6，2： | 7 |
| 2 | Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens显示文摘 | Kimmie Ng Josep Tabernero Jimmy Hwang Emilio Bajetta Sunil Sharma Salvatore A. Del Prete Edward R. Arrowsmith David P. Ryan Michaela Sedova Jin Jin Kamel Malek Charles S. Fuchs | 2013 | Clinical Cancer Research2013，，14： | 4 |
| 3 | 沙棘饮料的化学成分和最优口感的研究显示文摘沙棘(Hippophae rhamnoids L.),属于胡颓子属,在印度喜马偕尔邦地区称作'Chharma and Surch',沙棘能够在这种非常恶劣的气候条件下自然生长。本文介绍了制作沙棘饮料的一系列程序和如何储存饮料120d而不使其变质的方法。沙棘果实采自印度喜马偕尔邦河谷。用碎浆机提取沙棘汁,制作沙棘饮料要准备好合适比例的沙棘汁和制作饮料所需的糖。随着果浆比例的升高,维生素C的含量明显增加(P≤0.05),随着贮藏时间的延长,维生素C的含量明显降低。而随着糖和果浆的增加以及储存期的延长,还原性糖呈上升趋势。当饮料中果浆和糖的比例分别为10%和13%、12.5%和13%、15%和15%时,饮料最为宜口,给于较高的评价。在喜马偕尔邦,人们一直认为沙棘具有商业价值,但是其价值在此前一直没有得到足够的重视。 | 杨唐英 温秀凤 Shipra Saklani H. R. Sharma Virendra Singh | 2008 | 国际沙棘研究与开发2008，6，1： | 4 |
| 4 | Durability of Radiofrequency Ablation in Barrett’s Esophagus With Dysplasia显示文摘 | Nicholas J. Shaheen Bergein F. Overholt Richard E. Sampliner Herbert C. Wolfsen Kenneth K. Wang David E. Fleischer Virender K. Sharma Glenn M. Eisen M. Brian Fennerty John G. Hunter Mary P. Bronner John R. Goldblum Ana E. Bennett Hiroshi Mashimo Richard I | 2011 | Gastroenterology2011，，2： | 3 |
| 5 | Viral Regulation of RNA Granules in Infected Cells显示文摘RNA granules are cytoplasmic, microscopically visible, non-membrane ribo-nucleoprotein structures and are important posttranscriptional regulators in gene expression by controlling RNA translation and stability. TIA/G3BP/PABP-specific stress granules(SG) and GW182/DCP-specific RNA processing bodies(PB) are two major distinguishable RNA granules in somatic cells and contain various ribosomal subunits, translation factors, scaffold proteins, RNA-binding proteins, RNA decay enzymes and helicases to exclude m RNAs from the cellular active translational pool. Although SG formation is inducible due to cellular stress, PB exist physiologically in every cell. Both RNA granules are important components of the host antiviral defense. Virus infection imposes stress on host cells and thus induces SG formation. However, both RNA and DNA viruses must confront the hostile environment of host innate immunity and apply various strategies to block the formation of SG and PB for their effective infection and multiplication. This review summarizes the current research development in the field and the mechanisms of how individual viruses suppress the formation of host SG and PB for virus production. | Qiang Zhang Nishi R. Sharma Zhi-Ming Zheng Mingzhou Chen | 2019 | Virologica Sinica2019，34，2： | 3 |
| 6 | Effect of Alstonia scholaris bark extract on testicular function of Wistar rats显示文摘Aim:To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats.Methods:In male Wistar rats Alstonia scholaris bark extract was given by oral route at a dose of 200mg/day for60days,The fertility and testicular function were assessed by mating tests,sperm motility,sperm concentration,biochemical indices and testicular cell population dynamics.Results:Oral feeding with the extract at a dose of 200mg/day for the period of 60days did not cause body weight loss,while the weights of testes,epididymides,seminal vesicle and ventral prostate were significantly reduced.The production of step-19 spermatids was reduced by 79.6%in treated rats.The popu-lation of preleptotene and pachytene spermatocytes were decrased by61.9%and60.1%,respectively.Spematogo-nia and Sertoli cell population were also affected.The seminiferous tubule and Leydig cell nuclear area were reduced significantly(P<0.01)when compared to the controls..Reduced sperm count and motility yesulted in a total supprs-sion of fertility.A significant fall in the protein and sialic acid content of the testes,epididymides,seminal vesicle and ventral prostate as well as glycogen content of testes were also noticed.The fructose content in the seminal vesicle was lowered whereas the testicular cholesterol was elevated as compared with the controls.The following com-pounds were obtained from the extract with chromatographic separation over Si-gel column;α-amyrin,β-amyrin,lupiol acetate,venenative,rhazine and yohimbine,Conclusion:At the dose level employed,Alstonia scholaris bark extract has a significant antifertility effect in male rast;the primary site of action may be post meiotic germ cells(Step19spermatids). | R. S. Gupta Rakhi Sharma Aruna Sharma A.K. Bhatnager M.P. Dobhal Y.C. Joshi M.C. Sharma | 2002 | Asian Journal of Andrology2002，4，3： | 3 |
| 7 | Distributed Differences Structures Underlie Gating between the Kin Channel KAT1 and the Kout Channel SKOR显示文摘 | Janin Riedelsberger Tripti Sharma Wendy Gonzalez Pawel Gajdanowicz Samuel Elias Morales-Navarro Carlos Garcia-Mata Bernd Mueller-Roeber Fernando Danilo Gonzalez-Nilo Michael R. Blatt Ingo Dreyer | 2010 | Molecular Plant2010，3，1： | 2 |
| 8 | Liver Transplantation in Highest Acuity Recipients: Identifying Factors to Avoid Futility显示文摘 | Henrik Petrowsky Abbas Rana Fady M. Kaldas Anuj Sharma Johnny C. Hong Vatche G. Agopian Francisco Durazo Henry Honda Jeffrey Gornbein Victor Wu Douglas G. Farmer Jonathan R. Hiatt Ronald W. Busuttil | 2014 | Annals of Surgery2014，，6： | 2 |
| 9 | Radiofrequency ablation for treatment of medically inoperable stage I non–small cell lung cancer显示文摘 | Michael Lanuti Amita Sharma Subba R. Digumarthy Cameron D. Wright Dean M. Donahue John C. Wain Douglas J. Mathisen Jo-Anne O. Shepard | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，1： | 2 |
| 10 | Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival显示文摘 | Berna C. ?zdemir Tsvetelina Pentcheva-Hoang Julienne L. Carstens Xiaofeng Zheng Chia-Chin Wu Tyler R. Simpson Hanane Laklai Hikaru Sugimoto Christoph Kahlert Sergey V. Novitskiy Ana De Jesus-Acosta Padmanee Sharma Pedram Heidari Umar Mahmood Lynda Chin Ha | 2014 | Cancer Cell2014，，： | 2 |
| 11 | Radiation-induced proctosigmoiditis显示文摘 | R. Kochhar F. Patel S. C. Sharma S. Ayyagari R. Aggarwal M. K. Goenka B. D. Gupta S. K. Mehta | 1991 | Digestive Diseases and Sciences1991，，： | 2 |
| 12 | Adequacy of esophageal squamous mucosa specimens obtained during endoscopy: are standard biopsies sufficient for postablation surveillance in Barrett’s esophagus?显示文摘 | Neil Gupta Sharad C. Mathur John A. Dumot Vikas Singh Srinivas Gaddam Sachin B. Wani Ajay Bansal Amit Rastogi John R. Goldblum Prateek Sharma | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 13 | A rabbit model of non- cirrhotic portal hypertension by repeated injections of E. coli through indwelling cannulation of the gastrosplenic vein显示文摘BACKGROUND: Non-cirrhotic portal hypertension is acommon cause of portal hypertension in developing coun-tries. To understand its etiopathogenesis we developed ananimal model by repeated portal endotoxemia inducedthrough the gastrosplenic vein.METHODS: Twenty-nine rabbits (1.5-2.0 kg) were divid-ed into control (group n = 13) and experimental ( groupn = 16) groups. Heat killed E. coli were injected throughan indwelling cannula into the gastrosplenic vein in pre-sensitized animals. The animals were sacriflced at 1, 3 and6 months.RESULTS: The mean portal pressure in group animalswas significantly (P < 0. 05) higher than in group at 1(17.5 ±3.4 vs 10.4±2.2 mmHg), 3 (17.8±1.3 vs7.2 +3.6mmHg), and 6 (19.8±3.1 vs 10.3±4.8 mmHg) months.Similarly, the mean splenic weight in group was signifi-cantly greater than in group (P <0.05). Histopathologi-cally, the spleen showed medullary congestion, hemosid-rin-laden macrophages and mild fibrosis. Histologically,the liver had normal parenchyma with mild portal lympho-cytic infiltrates and kupffer cell hyperplasia. No significantanomalies were detected by liver function tests.CONCLUSIONS: The rabbit model showed significantsplenomegaly with a persistent increase in portal pressureand mild fibrosis without hepatic parenchymal injury, quiteakin to non-cirrhotic portal fibrosis as seen in humans. Re-current intra-abdominal infection may play an importantrole in the pathogenesis of non-cirrhotic portal fibrosis. | Swati Omanwar Moattar R. Rizvi Rachna Kathayat Brij K. Sharma Giryesh K. Pandey Mohammad A. Alam Veena Malhotra Shiv K. Sarin | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 2 |
| 14 | Ultrasound Molecular Imaging of Tumor Angiogenesis With an Integrin Targeted Microbubble Contrast Agent显示文摘 | Christopher R. Anderson Xiaowen Hu Hua Zhang Jose Tlaxca Anne-Emilie Declèves Robert Houghtaling Kumar Sharma Michael Lawrence Katherine W. Ferrara Joshua J. Rychak | 2011 | Investigative Radiology2011，，4： | 2 |
| 15 | Radiofrequency Ablation for Stage I Non-Small Cell Lung Cancer: Management of Locoregional Recurrence显示文摘 | Michael Lanuti Amita Sharma Henning Willers Subba R. Digumarthy Douglas J. Mathisen Jo-Anne O. Shepard | 2012 | The Annals of Thoracic Surgery2012，，3： | 2 |
| 16 | Metabolism of the colonic mucosa in patients with inflammatory bowel diseases: an in vitro proton magnetic resonance spectroscopy study显示文摘 | Krithika Balasubramanian Sandeep Kumar Rajeev R. Singh Uma Sharma Vineet Ahuja Govind K. Makharia Naranamangalam R. Jagannathan | 2009 | Magnetic Resonance Imaging2009，，1： | 2 |
| 17 | Changes in Plaque Lipid Content after Short-Term, Intensive versus Standard Statin Therapy: The YELLOW Trial显示文摘 | Annapoorna S. Kini Usman Baber Jason C. Kovacic Atul Limaye Ziad A. Ali Joseph Sweeny Akiko Maehara Roxana Mehran George Dangas Gary S. Mintz Valentin Fuster Jagat Narula Samin K. Sharma Pedro R. Moreno | 2013 | Journal of the American College of Cardiology2013，，： | 2 |
| 18 | Retention of the capsule endoscope: a single-center experience of 1000 capsule endoscopy procedures显示文摘 | Feng Li Suryakanth R. Gurudu Giovanni De Petris Virender K. Sharma Arthur D. Shiff Russell I. Heigh David E. Fleischer Janice Post Paula Erickson Jonathan A. Leighton | 2008 | Gastrointestinal Endoscopy2008，，1： | 2 |
| 19 | The Ti- Al- C system (titanium - aluminum - carbon)显示文摘 | D. Bandyopadhyay R. C. Sharma N. Chakraborti | 2000 | Journal of Phase Equilibria2000，，： | 2 |
| 20 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
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