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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 3 | The fusarium wilt resistance locus Fom-2 of melon contains a single resistance gene with complex features显示文摘 | TAREK J JOSEPH J K SHELLY J N CLAUDE E T RALPH A D | 2004 | The Plant Journal2004，39，： | 1 |
| 4 | Autophagy failure in Alzheimer's disease-loca- ring the primary defect显示文摘 | Ralph A N Ymlg D S | 2011 | Neurobiol Dis2011，43，1： | 1 |
| 5 | Efficient studies of long-distance Bmp5 gene regulation using bacterial artificial chromosomes显示文摘 | Ralph J D Gregory A M Michelle D J | 2000 | Proc Natl Acad Sci USA2000，97，4： | 1 |
| 6 | Significant differences in nucleocalsid morphology within the Paramyxoviridae 显示文摘 | Bhella D Ralph A Murphy L B | 2002 | Journal of general virology2002，83，8： | 1 |
| 7 | Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study显示文摘 | Ronenn Roubenoff Helen Parise Hélène A Payette Leslie W Abad Ralph D’Agostino Paul F Jacques Peter W.F Wilson Charles A Dinarello Tamara B Harris | 2003 | The American Journal of Medicine2003，，6： | 1 |
| 8 | Finite element model development for aircraft fuselage structures显示文摘 | Buehrle Ralph D Fleming Gary A and Papim Richard S | 2001 | S&V 2001(1)2001，2001，1： | 1 |
| 9 | Assessment of pholosynthetic performance of Prochloron in Lissoclinum patella in hosplte by chlorophyll fluorescence measurements显示文摘 | Schreiber U Gademann R Ralph P J Larkum A W D | 1997 | PI Ceil Physiol1997，38，： | 1 |
| 10 | Uncomplicated acute bronchitis 显示文摘 | Ralph Gonzales M D MSPH Merle A Sande M D | 2000 | Annals Internal Medicine2000，133，12： | 1 |
| 11 | Integrating urbanization into landscape-level ecological assessments 显示文摘 | Jeffrey D K alissa M Ralph J A | 2001 | Ecosystems2001，4，： | 1 |
| 12 | Incremental Training of Support Vector Machines显示文摘 | Shilton A Palaniswami M Ralph D | 2005 | IEEE Trans on Neural Netw2005，16，： | 1 |
| 13 | Silencing mutant SOD using RNAi protects against neurodegeneration and extends survival in an ALS model显示文摘 | Ralph G S Radcliffe P A Day D M | 2005 | Nat Med2005，11，4： | 1 |
| 14 | Elevated levels of acute phase proteins and plasminogen activator inhibitor (PAI-1) predict the development of type 2 diabetes mellitus:the insulin resistance atherosclerosis study (IRAS)显示文摘 | Festa A Ralph B D Russell P T | 2000 | Diabetes2000，，： | 1 |
| 15 | Advances in modifying lignin for enhanced biofuel production显示文摘 | Simmons B A Loque D Ralph J | 2010 | Current Opinion in Plant Biology2010，13，3： | 1 |
| 16 | Advances in modifying lignin for enhanced biofuel production 显示文摘 | Simmons B A Logue D Ralph J | 2010 | Current Opinion in Plant Biology2010，13，3： | 1 |
| 17 | The effect of non-condensible gases in water chiller condensers - literature survey and theoretical predictions显示文摘 | Ralph D R Web L B Warmiarachchi A S | 1980 | ASHRAE Trans1980，86，1： | 1 |
| 18 | Aniche for cyanobacteria containing chlorophyll d 显示文摘 | Kuhl M Chen M Ralph P J Larkum A W D | 2005 | Nature2005，433，： | 1 |
| 19 | Plasma homocysteine, hypertension incidence, ans blood pressure tracking: The Framingham heart study显示文摘 | Sundstrom johan Sullivan Lisa D A gostino Ralph B | 2003 | Hypertension2003，42，6： | 1 |
| 20 | Integrating urbanization into landscape-level ecological assessments 显示文摘 | JEFFREY D ALISSA M RALPH A | 2001 | Ecosystem2001，4，1： | 1 |
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