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| 1 | Spatial transmission and meteorological determinants of tuberculosis incidence in Qinghai Province,China:a spatial clustering panel analysis显示文摘Background:Tuberculosis(TB)is the notifiable infectious disease with the second highest incidence in the Qinghai province,a province with poor primary health care infrastructure.Understanding the spatial distribution of TB and related environmental factors is necessary for developing effective strategies to control and further eliminate TB.Methods:Our TB incidence data and meteorological data were extracted from the China Information System of Disease Control and Prevention and statistical yearbooks,respectively.We calculated the global and local Moran’s I by using spatial autocorrelation analysis to detect the spatial clustering of TB incidence each year.A spatial panel data model was applied to examine the associations of meteorological factors with TB incidence after adjustment of spatial individual effects and spatial autocorrelation.Results:The Local Moran’s I method detected 11 counties with a significantly high-high spatial clustering(average annual incidence:294/100000)and 17 counties with a significantly low-low spatial clustering(average annual incidence:68/100000)of TB annual incidence within the examined five-year period;the global Moran’s I values ranged from 0.40 to 0.58(all P-values<0.05).The TB incidence was positively associated with the temperature,precipitation,and wind speed(all P-values<0.05),which were confirmed by the spatial panel data model.Each 10°C,2 cm,and 1 m/s increase in temperature,precipitation,and wind speed associated with 9%and 3%decrements and a 7%increment in the TB incidence,respectively.Conclusions:High TB incidence areas were mainly concentrated in south-western Qinghai,while low TB incidence areas clustered in eastern and north-western Qinghai.Areas with low temperature and precipitation and with strong wind speeds tended to have higher TB incidences. | Hua-Xiang Rao Xi Zhang Lei Zhao Juan Yu Wen Ren Xue-Lei Zhang Yong-Cheng Ma Yan Shi Bin-Zhong Ma Xiang Wang Zhen Wei Hua-Fang Wang Li-Xia Qiu | 2016 | Infectious Diseases of Poverty2016，5，1： | 10 |
| 2 | CD30 expression in extranodal natural killer/T-cell lymphoma,nasal type among 622 cases of mature T-cell and natural killer-cell lymphoma at a single institution in South China显示文摘Background:Mature T-cell and natural killer(NK)-cell lymphomas compose a heterogeneous group of non-Hodgkin lymphomas,and extranodal NK/T-cell lymphoma,nasal type(ENKTL) is an aggressive subtype with sporadic CD30 expression.However,the significance of CD30 expression in ENKTL is controversial.We aimed to classify a large cohort of patients with mature T-cell and NK-cell lymphomas according to the 2016 World Health Organization(WHO) classification guidelines and to study the association between CD30 expression and prognosis of patients with ENKTL.Methods:We selected consecutive patients with mature T-cell and NK-cell lymphomas who attended our institution between September 1,2009 and August 31,2013.We classified the lymphomas according to the 2016 revision of the WHO classification of lymphoid neoplasms,analyzed the associations between CD30 expression and clinicopathologic features of ENKTL patients,and evaluated the prognostic implications of CD30 expression.Results:We identified 622 consecutive patients with mature T-cell and NK-cell lymphomas,including 317(51.0%)patients with ENKTL.In addition,CD30 expression was detected in 43(47.3%) of a subset of 91 patients with ENKTL.No clinicopathologic features were associated with CD30 expression,and CD30 positivity showed no prognostic significance in patients with ENKTL.Conclusions:ENKTL is the most common type of mature T-cell and NK-cell lymphoma diagnosed at our institution.CD30 is frequently expressed in ENKTL and represents a therapeutic target;however,it may not be a prognostic marker. | Yanfen Feng Huilan Rao Yiyan Lei Yuhua Huang Fang Wang Yu Zhang Shaoyan Xi Qiuliang Wu Jianyong Shao | 2017 | Chinese Journal of Cancer2017，36，6： | 10 |
| 3 | Combining sap flow measurement-based canopy stomatal conductance and ^(13)C discrimination to estimate forest carbon assimilation显示文摘The available methods for studying C uptake of forest and their problems in practices are reviewed, and a new approach to combining sap flow and 13C techniques is proposed in this paper. This approach, obtained through strict mathematic derivation, combines sap flow measure-ment-based canopy stomatal conductance and 13C discrimi-nation to estimate instantaneous carbon assimilation rate of a forest. Namely the mean canopy stomatal conductance (gc) acquired from accurate measurement of sap flux density is integrated with the relationship between 13C discrimination (?) and Ci/Ca (intercellular/ambient CO2 concentrations) and with that between Anet (net photosynthetic rate) and gCO2 (stomatal conductance for CO2) so that a new relation be-tween forest C uptake and ? as well as gc is established. It is a new method of such kind for studying the C exchange be-tween forest and atmosphere based on experimental ecology. | ZHAO Ping LU Ping MA Ling SUN Guchou RAO Xingquan CAI Xi'an ZENG Xiaoping | 2005 | Chinese Science Bulletin2005，50，18： | 9 |
| 4 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 5 | Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts显示文摘Phosphodiesterases (PDE ) 是降级的酶细胞的营地和 cGMP 并且为调整周期的核苷酸因此是必要的。PDE 的至少 11 个家庭被识别了,有特殊结构,活动,表情,和织物分发的各个。PDE type-3, -4, 和 -5 (PDE3, PDE4, PDE5 ) 对 cardiomyocyte 的特定的区域局部性例如 sarcoplasmic 蜂窝胃和 Z 圆盘,在他们是可能的影响发信号到收缩性的结束受动器的 cAMP/cGMP 的地方。几 PDE 禁止者展览显著血液动力学并且可能对临床的实践珍贵的 inotropic 性质。特别地, PDE3 禁止者有能被用于短期的 inotropic 的强心的效果支持的有势力,特别处于肾上腺素能的刺激是不够的状况。与这评论最相关, PDE 禁止者也被发现了在心有 cytoprotective 效果。例如,当在 ischemic 攻击前给时,而 PDE5 禁止者,它广泛地包括三使用了可勃起的机能障碍药(sildenafil, vardenafil 和 tadalafil ) , PDE3 禁止者被显示了是 cardioprotective,当在局部缺血以前或在灌注之上管理了时,能导致显著 cardioprotection。这篇文章提供水流的概述实验室和临床的证据,以及 PDE3, PDE4 和 PDE5 的禁止者在正常和 ischemic 心上由施加他们的有益的效果的细胞的机制。看起来, PDE 禁止者作为能在批评状况下面改进心脏的性能和房间幸存的临床上适用的代理人保持大诺言,例如 ischemic 心脏病,心肺绕过外科,和心失败。 | Yuan James RAO Lei XI | 2009 | Acta Pharmacologica Sinica2009，30，1： | 6 |
| 6 | Potential mechanism of cholagogic effect about Gardenia Jasminoides Ellis(Zhizi)-mediated increase of bile acids urinary excretion in normal rats显示文摘Objectives: Gardenia Jasminoides Ellis(Zhizi), belonging to Rubiaceae family, has been traditionally used for treatment cholestasis and jaundice for centuries in Asian countries. In the theory of Traditional Chinese Medicines, Zhizi could dispel dampness and heat via the urine to execute its choleretic effects. However, the potential molecular mechanism has been still poorly clarified. Here, we investigated the effect of different dose of Zhizi aqueous extract powder(0.3 g/kg/d and 0.9 g/kg/d) on urinary excretion of bile acids(BAs), and defined the potential mechanism via renal BAs efflux transporters Mrp2 and Mrp4 in normal rats.Methods: Male Wistar rats were orally administrated with 0.3 or 0.9 g/kg/d dose of Zhizi aqueous extract powder for 2 weeks, then body weight, serum aminotransferase, total BAs concentrations in liver, bile,serum, kidney and urine, 1 h bile flow, 12-h urinary volume, biliary and urinary excretion amount of total BAs as well as protein expression of major renal BAs efflux transporter Mrp2 and Mrp4, were all evaluated.Results: Zhizi especially the high dose of Zhizi aqueous extract powder could reduce hepatic total BAs concentration. Additionally, bile flow and biliary excretion had no significant difference, but the remarkable increasing urinary excretion of BAs and 2 to 3 folds up-regulated renal Mrp2 expression were observed after administrated with Zhizi as compared with the control group.Conclusion: The findings indicate that Zhizi reduces hepatic total BAs level by increasing urinary excretion rather than the biliary excretion of BAs, which, in turn ascribed to elevated protein expression of Mrp2 at apical membrane of renal tubular epithelial cells. | Fan Zhang Yu-hui Wei Ying-ting Duan Yan-shu Zhao Li-li Xi Zhi Rao Jian-ping Zhang Guo-qiang Zhang Xin-an Wu | 2018 | Chinese Herbal Medicines2018，10，4： | 2 |
| 7 | High-dose Chemotherapy Combined with Autologous Hematopoietic Stem Cell Transplantation as Frontline Therapy for Intermediate/High-risk Diffuse Large B Cell Lymphoma显示文摘The role of autologous hematopoietic stem cell transplantation(auto-HSCT)following high-dose chemotherapy has been validated and accepted as a standard treatment for patients with relapsed diffuse large B-cell lymphoma(DLBCL).However,its clinical efficacy as frontline therapy remains to be elucidated.This study aimed to examine the feasibility of frontline auto-HSCT for newly diagnosed intermediate/high-risk DLBCL patients.We retrospectively reviewed the data of 223 patients treated with frontline auto-HSCT or chemotherapy alone(year 2008-2014)from four hospitals.The median follow-up time was 29.4 months.Between the two treatment arms among the intermediate/high-risk DLBCL patients,the 3-year overall survival(OS)and progression-free survival(PFS)rates of patients given frontline auto-HSCT were 87.6%and 81.9%,respectively,and the chemotherapy-alone group showed 3-year OS and PFS rates of 64.9%and 59.59%,respectively.Compared with the chemotherapy-alone group,the frontline auto-HSCT could eliminate the adverse impact of non-germinal center B-cell(GCB)type.In addition,in the frontline auto-HSCT group,patients who achieved complete response(CR)at auto-HSCT had a longer survival time than those who did not achieve CR.Our results suggested that frontline auto-HSCT could improve the prognosis of intennediate/high-risk DLBCL patients. | Qin WEN Li GAO Jing-kang XIONG Qiong LI San-bin WANG Ji-shi WANG Fang LIU Cheng ZHANG Yao LIU Pei-yan KONG Xian-gui PENG Jun RAO Lei GAO Xi ZHANG | 2021 | Current Medical Science2021，41，3： | 2 |
| 8 | Controlling the Interface Reaction in AllsB4033w/AC8A Composite by Nitrided Nano-coating显示文摘 | Bi G Rao Q Xi F | 2004 | Materials Letters2004，58，： | 1 |
| 9 | Polycomb repressor complex- 2 is a novel target for mesothelioma therapy显示文摘 | KEMP CD RAO M XI S | 2012 | Clin Cancer Res2012，18，1： | 1 |
| 10 | Towards enabling peer-to-peer grids显示文摘 | FOX G PALLICKARA S RAO Xi | 2005 | Journal of Concurrency and Computation: Practice and Experience2005，17，78： | 1 |
| 11 | Controlling the interface reaction in Al18B4O33w/AC8A composite by nitrided nano-coating显示文摘 | BI G RAO Q XI F | 2004 | Mater Lett2004，58，5： | 1 |
| 12 | Controlling the Interface Reaction in Al18 B4O33/AC8A Composite by Nitrided Nano-coating 显示文摘 | BI Gang RAO Qunli XI Fen | 2004 | Materials Letters2004，58，5： | 1 |
| 13 | Controlling the interface reaction in Al18B4O33w/AC8A composite by nitrided nano-coating显示文摘 | GANG BI QUNLI RAO FEN XI | 2004 | Materials Letters2004，58，： | 1 |
| 14 | Controlling the interface reaction in Al18B4O33/AC8A composite by nitrided nano- coating 显示文摘 | Bi G Rao Q L Xi F | 2004 | Materials Letters2004，58，5： | 1 |
| 15 | Energy efficiency and energy saving potential in China: An analysis based on slacks-based measure model显示文摘 | Xi Rao Jun Wu Zongyi Zhang Bin Liu | 2011 | Computers & Industrial Engineering2011，，3： | 1 |
| 16 | Network pharmacology and in vitro study of Fengreqing oral liquid(风热清口服液) in the intervention of wind-heat pattern显示文摘OBJECTIVE:To investigate the underlying mechanism of the effect of Fengreqing oral liquid(风热清口服液,FOL)on wind-heat pattern(WHP).METHODS:In this study,we predicted the potential targets of FOL via the approach of network pharmacology and verified it by in vitro inflammation model.In the network pharmacology part,two strategies,namely the direct target search and the indirect one,were used to collect the target sets of FOL in WHP treatment.The enrichment analysis was carried out by David database and Clue Go plug-in in Cytoscape.Furthermore,the potential targets were mapped in the candidate pathways.In the verification experiment section,in vitro model of lipopolysaccharide(LPS)induced RAW 264.7 was used to confirm the predictive results in the network pharmacology part.RESULTS:Through the two screening strategies,a total of 141 non-repetitive intervention targets of FOL on WHP were obtained.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis showed that the intervention effect was mainly focused on the anti-inflammatory effect,and the Toll-like receptor signaling pathway was one of the most critical regulatory pathways.Further mapping analysis showed that phosphatidylinositol 3-kinase(PI3 K)-protein kinase B(AKT)signaling transfer might be the key part of regulating the concentration of inflammation mediators of FOL in the Toll-like receptor signaling pathway.In vitro experiment showed that FOL significantly reduced the levels of NO,IL-1,IL-6,and TNF-αproduced by RAW264.7 induced by LPS.Further immunofluorescence found that this effect is related to the regulation of PI3 K-AKT pathway activity by FOL.CONCLUSION:FOL can intervene in WHP by regulating the content of inflammatory mediators via the PI3 K-AKT pathway. | YANG Ruocong RAO Zhili LI Xiangyu WANG Dejian PENG Xi ZENG Nan | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 1 |
| 17 | Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells显示文摘 | JIANG Ying ZHOU Xue CHEN Xi YANG Guang-tao WANG Qian RAO Kai-ming XIONG Wei YUAN Jing | | 0，，01： | 1 |
| 18 | Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance显示文摘Multiple drug resistance(MDR)is a tough problem in developing hepatocellular carcinoma(HCC)therapy.Here,we developed TPGS-coated cationic liposomes with Bcl-2 siRNA corona to load doxorubicin(Dox)i.e.,Bcl-2 siRNA/Dox-TPGS-LPs,to enhance anticancer effect of Dox in HCC-MDR.TPGS i.e.,d-α-tocopheryl polyethylene glycol 1000 succinate,inhibited Pglycoprotein(P-gp)efflux pump and Bcl-2 siRNA suppressed anti-apoptotic Bcl-2 protein.The Bcl-2 siRNA loaded in the liposomal corona was observed under transmission electron microscopy.The stability and hemolysis evaluation demonstrated Bcl-2 siRNA/Dox-TPGSLPs had good biocompatibility and siRNA-corona could protect the liposomal core to avoid the attachment of fetal bovine serum.In drug-resistant cells,TPGS effectively prolonged intracellular Dox retention time and siRNA-corona did improve the internalization of Dox from liposomes.In vitro and in vivo anticancer effect of this dual-functional nanostructure was examined in HCC-MDR Bel7402/5-FU tumor model.MTT assay confirmed the IC50 value of Dox was 20–50 fold higher in Bel7402/5-FU MDR cells than that in sensitive Bel7402 cells.Bcl-2 siRNA corona successfully entered the cytosol of Bel7402/5-FU MDR cells to downregulate Bcl-2 protein levels in vitro and in vivo.Bcl-2 siRNA/Dox-TPGS-LPs showed superior to TPGS-(or siRNA-)linked Dox liposomes in cell apoptosis and cytotoxicity assay in Bel7402/5-FU MDR cells,and 7-fold greater effect than free Dox in tumor growth inhibition of Bel7402/5-FU xenograft nude mice.In conclusion,TPGS-coated cationic liposomes with Bcl-2 siRNA corona had the capacity to inhibit MDR dual-pathways and subsequently improved the anti-tumor activity of the chemotherapeutic agent co-delivered to a level that cannot be achieved by inhibiting a MDR single way. | Yinghuan Li Xi Tan Xuhan Liu Lingyan Liu Yan Fang Rong Rao Yuanyuan Ren Xiangliang Yang Wei Liu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，5： | 1 |
| 19 | Effect of thermal processing and fermentation with Chinese traditional starters on characteristics and allergenicity of wheat matrix显示文摘Wheat allergy has become a serious health threat worldwide and its prevalence has increased alarmingly in the past few years.Factors such as food matrix and food processing may alter the structure of wheat proteins,and hence affect its allergenic properties.However,few reports have focused on the influence of Chinese traditional starter fermentation on wheat allergy.In this study,5 starters from different regions of China were used for fermentation,and protein characteristics were monitored by sodium dodecyl sulfate polyacrylamide gel electropheresis,and immunoreactivity analyzed by immunoassay with allergenic serum was obtained from New Zealand white rabbits.The allergenicity of steamed and baked matrices was also evaluated.The results showed that the allergenicity of wheat dough was basically increased at the beginning and then decreased during fermentation,but specific trends depend on different starters.With the progress of fermentation,especially as pH value decreased to 3.0-4.0,the allergenicity decreased significantly.Baking and steaming can reduce the allergenicity of wheat matrix,but fermentation is not a key factor affecting the allergenic activity of proteins.Our results can provide a theoretical basis for controlling wheat allergenicity in food proces sing or producing hypoallergenic food. | Huan Rao Xi Li Wentong Xue | 2023 | Food Science and Human Wellness2023，12，3： | 1 |
| 20 | Recent Progress in Fiber Optofluidic Lasing and Sensing显示文摘Fiber optofluidic laser(FOFL)integrates optical fiber microcavity and microfluidic channel and provides many unique advantages for sensing applications.FOFLs not only inherit the advantages of lasers such as high sensitivity,high signal-to-noise ratio,and narrow linewidth,but also hold the unique features of optical fiber,including ease of integration,high repeatability,and low cost.With the development of new fiber structures and fabrication technologies,FOFLs become an important branch of optical fiber sensors,especially for application in biochemical detection.In this paper,the recent progress on FOFL is reviewed.We focuse mainly on the optical fiber resonators,gain medium,and the emerging sen sing applicatio ns.The prospects for FOFL are also discussed.We believe that the FOFL sensor provides a promising technology for biomedical analysis and environmental monitoring. | Xi YANG Chaoyang GONG Yiling LIU Yunjiang RAO Mateusz SMIETANA Yuan GONG | 2021 | Photonic Sensors2021，11，2： | 1 |
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