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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?显示文摘AIM To analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis.METHODS Incidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy.All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed.Further data was collected on all specimens demonstrating carcinoma,dysplasia and polypoid growths.RESULTS The study included 4027 patients.The majority(97%) of specimens exhibited gallstone or cholecystitis related disease.Polyps were demonstrated in 44(1.09%),the majority of which were cholesterol based(41/44).Dysplasia,ranging from low to multifocal high-grade was demonstrated in 55(1.37%).Incidental primary gallbladder adenocarcinoma was detected in 6 specimens(0.15%,5 female and 1 male),and a single gallbladder revealed carcinoma in situ(0.02%).This large single centre study demonstrated a full range of gallbladder disease from cholecystectomy specimens,including more than 1% neoplastic histology and two cases of macroscopically occult gallbladder malignancies.CONCLUSION Routine histological evaluation of all elective and emergency cholecystectomies is justified in a United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology. | Krashna Patel Khaled Dajani Satheesh Iype Nikolaos A Chatzizacharias Saranya Vickramarajah Susan Davies Rebecca Brais Siong S Liau Simon Harper Asif Jah Raaj K Praseedom Emmanuel L Huguet | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 2 |
| 3 | Identification of an opd (Organophosphate Degradation) Gene in an Agrobacterium Isolate显示文摘 | Irene Horne Tara D S Rebecca L | 2002 | Applied and Environmental Microbiology2002，68，7： | 1 |
| 4 | Comparison of the Etest and the NCCLS-approved agar dilution method to detect metronidazole and clarithromycin resistant Helicobacter pylori显示文摘 | Michael S Osato Rita Reddy Siddartha G Reddy Rebecca L Penland David Y Graham | 2001 | International Journal of Antimicrobial Agents2001，，1： | 1 |
| 5 | Epidemiological and molecular trends of norwalk - like viruses associated with outbreaks of gastroenteritis in the United States 显示文摘 | REBECCA L F STEPHAN S M JACQUELINE S N | 2002 | J Infec Dis2002，186，： | 1 |
| 6 | Four year prospective evaluation of nosocomial bacteremia:epidemiology,microbiology,and patient outcome显示文摘 | Rebecca L Carol C Sanjay S | 2000 | Diagnostic Microbiology and Infectious Disease2000，38，： | 1 |
| 7 | Polyethylene Glycol-containing Polyurethanes for Biomedical Applications显示文摘 | Siska C Ngoc P L Etienne S Martyn D Alex S Rebecca G Stephen D Mike W Hugh W Simon C | 1998 | Polymer International1998，46，3： | 1 |
| 8 | Short tandem repeat sequencing on the 454 platform 显示文摘 | Mehssa S Odile L Rebecca J | 2011 | Forensic Sci Int2011，15，3： | 1 |
| 9 | Effect of dietary lipid source on the growth,tissue composition and hematological parameters of largemouth bass (Micropterus salmoides)显示文摘 | BOBBAN S REBECCA L STEVEN R | 2006 | Aquaculture2006，255，： | 1 |
| 10 | Monitoring of yeast population changes during a continuous wine fermentation by molecular methods显示文摘 | Cocolin L Manzano M Rebecca S | 2002 | American Journal of Enology and Viticulture2002，53，1： | 1 |
| 11 | Monitoring of yeast population changes during a continuous wine fermentation by molecular methods显示文摘 | COCOLIN L MANZANO M REBECCA S | 2002 | American Journal of Enology and Viticulture2002，53，1： | 1 |
| 12 | An autogeneic feeder cell system that efficiently supports growth of undifferentiated human embryonic stem cells 显示文摘 | Petra S Majlinda L Rebecca S | 2005 | Stem Cells2005，23，： | 1 |
| 13 | An Electronic,Aptamerbased small-molecule sensor for the rapid, label-free detection of cocaine in adulterated samples and biological fluids 显示文摘 | Brian R B Rebecca Y L McCall S W | 2006 | J Am Chem Soc2006，，128： | 1 |
| 14 | Massive hepatic apoptosis associated with TGF-1 activation after Fas ligand treatment of IGF binding PROTEIN-1-deficient mice显示文摘 | Mary Ann S Crissey Rebecca Taub | 2002 | Jclin Invest2002，111，1： | 1 |
| 15 | The risk of the hemolytic uremic syndrome after antibiotic Ixeatment of Escheichia coli O157:H7 infections 显示文摘 | Wong S Srdjan Jelacic B S Rebecca L H | 2000 | The New England Journal of Medicine2000，342，： | 1 |
| 16 | Effect of dietary lipid source on the growth, tissue composition and hematological parameters of largemouth bass ( Micropterus salmoides ) 显示文摘 | Robban S Rebecca L Steven R | 2006 | Aquaculture2006，255，14： | 1 |
| 17 | Rapidly measured indicators of recreational water quality are predictive of swimming-associated gastrointestinal illness 显示文摘 | TIMOTHY J W REBECCA L C ELIZABETH S | 2006 | Environ Health Perspect2006，114，1： | 1 |
| 18 | The risk of the hemolytic - uremic syndrome after antibiotic treatment of Escheichia coli O157:H7 infections显示文摘 | Craig S WONG MD Srdjan Jelacic BS Rebecca L Habeeb BS | 2000 | The New England Journal of Medicine2000，29，： | 1 |
| 19 | Herpess simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family显示文摘 | Rebecca I M Morgyn S W Brain J L | 1996 | Cell1996，87，： | 1 |
| 20 | Monitoring animal behavior and environmental interactions using wireless sensor networks, GPS collars and satellite remote sensing显示文摘 | Rebecca N H Dave L S Greg J | 2009 | Sensors2009，9，5： | 1 |
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