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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | Four year prospective evaluation of nosocomial bacteremia:epidemiology,microbiology,and patient outcome显示文摘 | Rebecca L Carol C Sanjay S | 2000 | Diagnostic Microbiology and Infectious Disease2000，38，： | 1 |
| 3 | Metronomic therapy for refractory/relapsed lymphoma:The PEP-C low-dose oral combination chemotherapy regimen显示文摘 | Morton C Gia R Rebecca L | 2012 | Hematology2012，17，： | 1 |
| 4 | Structural basis of caspase inhibition by XIAP:differential roles of linker versus the BIR domain显示文摘 | Huang Y Park Y C Rebecca L R | 2001 | Cell2001，104，5： | 1 |
| 5 | Polyethylene Glycol-containing Polyurethanes for Biomedical Applications显示文摘 | Siska C Ngoc P L Etienne S Martyn D Alex S Rebecca G Stephen D Mike W Hugh W Simon C | 1998 | Polymer International1998，46，3： | 1 |
| 6 | Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington' s disease显示文摘 | Daniel B R Rebecca T L Mark H M C | 2012 | Bioehem J2012，442，1： | 1 |
| 7 | A quantitative approach to evaluating ecosystem services 显示文摘 | Rebecca A L lndrajeet C | 2013 | Ecological Modelling2013，257，： | 1 |
| 8 | Effectiveness of inter- ventions targeting physical activity, nutrition and healthy weight for u- niversity and college students:A systematic review and meta-analysis 显示文摘 | RONALD C SARAH A REBECCA L | 2015 | Int J Bebav Nut Phy Act2015，12，1： | 1 |
| 9 | Inhibition of cancer cell invasion and metastasis by genistein 显示文摘 | Janet M Pavese Rebecca L Farmer Raymond C Ber- gan | 2010 | Cancer Metastasis Rev2010，29，： | 1 |
| 10 | Middle school teachers' expecta- tions of organizational behaviors of students with learning disabilities 显示文摘 | Rebecca C Margaret E Harry L | 2007 | Journal of Instructional Psychology2007，34，2： | 1 |
| 11 | Development of a transformation system in the swainsonine producing, slow growing endophytic fungus,Undifilure oxytropis显示文摘 | SUMAN M ANJUS L D REBECCA C | 2010 | J Microbiol Method2010，81，2： | 1 |
| 12 | Characterization of the timing and prevalence of receptor tyrosine kinase expression changes in oesophageal carcinogenesis显示文摘 | Anna L Paterson Maria O’Donovan Elena Provenzano Liam J Murray Helen G Coleman Brian T Johnson Damian T McManus Marco Novelli Laurence B Lovat Rebecca C Fitzgerald | 2013 | J Pathol2013，，1： | 1 |
| 13 | Rapidly measured indicators of recreational water quality are predictive of swimming-associated gastrointestinal illness 显示文摘 | TIMOTHY J W REBECCA L C ELIZABETH S | 2006 | Environ Health Perspect2006，114，1： | 1 |
| 14 | Depreesion,Visual Acuity,Comorbidity and disability associated with age-related macular degeneration显示文摘 | Barbara L Brody Anthony C Gamst Rebecca A Williams | 2001 | Ophthalmology2001，108，10： | 1 |
| 15 | Interventions to Support a Palliative Care Approach in Patients with Chronic Obstructive Pulmonary Disease: an Integrative Review 显示文摘 | Rebecca T D David C C Jane L P | 2012 | International Journal of Nursing Studies2012，49，11： | 1 |
| 16 | Drought planning and water alloca- tion:an assessment of local capacity in Minnesota显示文摘 | REBECCA L P ROB C L REID K | 2004 | Journal of Environ- mental Management2004，73，： | 1 |
| 17 | Inheritance of tomato late blight resistance derived from Lycopersicon esculentum LA1033 and identification of Molecular markers 显示文摘 | Rebecca C L Garbner R G | 2001 | Hort Science2001，35，3： | 1 |
| 18 | Zinc protoporphyrin/heme ratio for diagnosis of preanemic iron deficiency 显示文摘 | REBECCA L TIMOTHY R H MAURICE C L | 1999 | Pediatrics1999，104，3： | 1 |
| 19 | Inheritance of tomato late blight resistance derived from Lycopersicon esculentum LA1033 and identification of Molecular makers显示文摘 | REBECCA C L GARBNER R G | 2001 | Hort Science2001，35，3： | 1 |
| 20 | Identification of human remains by immobilized sequence-specific oligonucleotide probe analysis mtDNA hypervariable regions Ⅰ and Ⅱ 显示文摘 | Matthew N G Cassandra D C Rebecca L R | 2003 | Forensic Sci2003，44，3： | 1 |
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