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| 1 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 2 | Synthesis, crystal structure and photophysical properties of europium (III) and terbium(III) complexes with pyridine-2,6-dicar- boxamide 显示文摘 | Stefania T Patrieia M G Rene' de G | 2007 | lnorg Chim Acta2007，360，1： | 1 |
| 3 | Modeling MOV-protected series capacitors for short-circuit studies显示文摘 | Coursol M Chinh T N Rene L | | 0，，01： | 1 |
| 4 | Hemato-logic and serum biochemical changes in Salmonellaser Typhimurium-iniected calves显示文摘 | Renato L S Renee M T Andreas J B | 2002 | Am J Vet Res2002，63，8： | 1 |
| 5 | Phloem-specific expression of the pumpkin fruit trypsin inhibitor 显示文摘 | Joanne M D Renee C S Gary A T | 2001 | Planta2001，212，1： | 1 |
| 6 | Biodegradation of BTEX in a Fungal Biofilter:Influence of Operational Parameters,Effect of Shock-Loads and Substrate Stratification显示文摘 | Rene E R Mohammad B T Veiga M C | 2012 | Bioresour Technol2012，116，7： | 1 |
| 7 | A predominantlyclonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality 显示文摘 | Loo VG Poirier L Miller MA Oughton M Libman MD Michaud S Bourgault AM Nguyen T Frenette C KellyM Vibien A Brassard P Fenn S? Dewar K Hudson TJ?Horn R Rene P Monczak Y Dascal A | 2005 | N Engl J Med2005，353，23： | 1 |
| 8 | Benign cellular responses in rats to different wear particles in intra-articular and intramedullary environments显示文摘 | Harm M Rene K Wikky T | 1997 | J Bone Joint Surg1997，79，： | 1 |
| 9 | Allergenici-ty and antigenicity of chicken egg ovomucoid(Gald III)compared withovalbumin(Gald I)in children with egg allergy and in mice显示文摘 | BERNHISEI-BROADBENT J HOWARD M RENEE Ze t al | 1994 | J Aller-gy Clin Immunol1994，3，6： | 1 |
| 10 | Correlation between electrocorticographic and motor phenomena induced by pentamethy lenetetrazol during ontogenesis in rats显示文摘 | Renee S Pavel M Stanislav T | 1984 | Experimental Neurology1984，84，： | 1 |
| 11 | Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase 显示文摘 | Rene Jcrgensen Max M T Scgaard A | 2000 | Biol Chem2000，275，16： | 1 |
| 12 | Corrective maintenance through dynamic work allocation and pre-emption:case study and application显示文摘 | QUINTANA R LEUNG M T RENE V J | 2009 | International Journal of Production Research2009，47，13： | 1 |
| 13 | In vivo magnetic resonance imaging of experinmental thrombosis in a rabbit model显示文摘 | Michael T Rene M Botnar AS | 2001 | Arterioscler Thromb Vasc Biol2001，21，9： | 1 |
| 14 | Effect of silicon surface termination on copper deposition in deionized water显示文摘 | SANG W L RENEE T M PIERO A P | 2001 | J Electrochem Soc2001，148，1： | 1 |
| 15 | Nurse staffing and education and hospital mortality in nine European countries: a retrospective observational study显示文摘 | Linda H Aiken Douglas M Sloane Luk Bruyneel Koen Van den Heede Peter Griffiths Reinhard Busse Marianna Diomidous Juha Kinnunen Maria Kózka Emmanuel Lesaffre Matthew D McHugh M T Moreno-Casbas Anne Marie Rafferty Rene Schwendimann P Anne Scott Carol Tishel | 2014 | The Lancet2014，，： | 1 |
| 16 | 较大直肠腺瘤中经肛门内镜显微手术与内镜下黏膜切除术的随机对照试验(TREND研究)显示文摘摘要 目的 非随机研究表明内镜下黏膜切除术(endoscopic mucosal resection,EMR)在切除直肠较大腺瘤时与经肛门内镜显微手术(transanal endoscopic microsurgery,TEM)同样有效,但EMR可能更具成本效益且相对安全。本试验旨在对比摘除较大直肠腺瘤时EMR与TEM的临床结局与成本效益。 | Renee M Barendse Gijsbert D Musters Eelco J R de Graaf Frank J C van den Broek Esther C J Consten Pascal G Doornebosch James C Hardwick Ignace H J T de Hingh Chrisiaan Hoft Jeroen M Jansen A W Marc van Milligen de Wit George P van der Schelling Erik J Schoon Matthijs P Schwartz Bas L A M Weusten Marcel G Dijkgraaf Paul Fockens Willem A Bemelman Evelien Dekker TREND研究小组 李佳宁(译) 吴东(校) | 2018 | 英国医学杂志中文版2018，21，11： | 0 |
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