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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Physical activity in primary and secondary prevention of cardiovascular disease:Overview updated显示文摘Although the observed progress in the cardiovascular disease treatment, the incidence of new and recurrent coronary artery disease remains elevated and constitutes the leading cause of death in the developed countries. Three-quarters of deaths due to cardiovascular diseases could be prevented with adequate changes in lifestyle, including increased daily physical activity. New evidence confirms that there is an inverse dose-response relationship between physical activity and cardiovascular disease and mortality risk. However, participation in moderate to vigorous physical activity may not fully attenuate the independent effect of sedentary activities on increased risk for cardiovascular diseases. Physical activity also plays an important role in secondary prevention of cardiovascular diseases by reducing the impact of the disease, slowing its progress and preventing recurrence. Nonetheless, most of eligible cardiovascular patients still do not benefit from secondary prevention/cardiac rehabilitation programs. The present review draws attention to the importance of physical activity in the primary and secondary prevention of cardiovascular diseases. It also addresses the mechanisms by which physical activity and regular exercise can improve cardiovascular health and reduce the burden of the disease. | Alberto J Alves Joao L Viana Suiane L Cavalcante Nórton L Oliveira JoséA Duarte Jorge Mota JoséOliveira Fernando Ribeiro | 2016 | World Journal of Cardiology2016，8，10： | 6 |
| 3 | Optical spectroscopy of Er^3+ and Yb^3+ co-doped fluoroindate glasses显示文摘 | RIBEIRO C T M ZANATTA A R NUNES L A O | 1998 | J Appl Phys1998，83，4： | 1 |
| 4 | Conventional and microwave induced pyrolysis of coffee hulls for the production of hydrogen rich fuel gas显示文摘 | DOMINGUEZ A MENENDEZ J A FERNANDEZ Y PIS J J VALENTE NABAIS JM CARROTT J M RIBEIRO CARROTT M M L | | 0，，1： | 1 |
| 5 | Effects of taurine supplementation upon food intake and central insulin signaling in malnourished mice fed on a high-fat diet显示文摘 | Camargo R L Batista T M Ribeiro R A | 2013 | Advances in Experi- mental Medicine and Biology2013，4776，： | 1 |
| 6 | Fault detection of open-switch damage in voltage fed PWM motor drive systems 显示文摘 | Ribeiro R L A Jacobina C B Silva E R C D | 2003 | IEEE Transactions on Power Electronics2003，18，2： | 1 |
| 7 | Mood swings in patients with Crohn's disease: incidence and associat ed factors显示文摘 | Lima F D Ribeiro T C Chebli L A | 2012 | Rev Assoc Med Bras2012，58，4： | 1 |
| 8 | Solvent recovery from soybean oil/hexane mis- celia by polymeric membranes 显示文摘 | RIBEIRO A P B DE MOUR J M L N GONCALVES L A G | 2006 | Journal of Membrane Science2006，282，12： | 1 |
| 9 | Comparative effects of salinity and water stress on photosynthesis, water relations and growth of Jatropha curcas plant 显示文摘 | SILVA E N RIBEIRO R V FERREIRA-SILVA S L VIEGAS R A SILVEIRA J A G | 2010 | Journal of Arid Environment2010，74，10： | 1 |
| 10 | A case study on process optimization using the gradient loss function显示文摘 | Elsayed E A | 1995 | Int J Prod Res1995，33，12： | 1 |
| 11 | Case study on the strategy and application of enhancement solutions to improve remediation of soils contaminated with Cu,Pb and Zn by means of electrodialysis显示文摘 | Ottoson L M Pederscn A J Ribeiro A B | 2005 | Engi-neering Geology2005，77，： | 1 |
| 12 | Possible applications for municipal solid waste fly ash 显示文摘 | FERREIRA C RIBEIRO A OTYOSEN L | 2003 | Journal of Hazardous Materials2003，96，23： | 1 |
| 13 | Fault detection of open-switch damage in voltage-fed PWM motor drive systems显示文摘 | Ribeiro R L A Jacobina C B Silva E R C | 2003 | IEEE Transactions on Power Electronics2003，18，2： | 1 |
| 14 | Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine显示文摘 | BONFLEUR M L BORCK P C RIBEIRO R A | 2015 | Life Sci2015，135，： | 1 |
| 15 | Modelling the adsorption kinetics of erythromycin onto neutral and anionic resins显示文摘 | RIBEIRO M H L RIBEIRO I A C | | 0，，： | 1 |
| 16 | Microwave synthesis of YAG∶Eu by solgel methodology显示文摘 | PEREIRA P F S CAIUT J M A RIBEIRO S J L | 2007 | Journal of Luminescence2007，126，2： | 1 |
| 17 | Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice显示文摘 | Ronaldo A Ribeiro Mariana L Vale Sara M Thomazzi Adriana B.P Paschoalato Steve Poole Sergio H Ferreira Fernando Q Cunha | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 18 | The impact of organic and inorganic selenium on the immune system of growing broilers submitted to immune stimulation and heat stress显示文摘 | Silva I C M Ribeiro A M L Canal C W | 2010 | Braz J Poultry Sci2010，12，4： | 1 |
| 19 | Analysis of the reflective-matched fiber Bragg grating sensing interrogation scheme显示文摘 | Lobo Ribeiro A B Ferreira L A Santos J L | 1997 | Applied Optics1997，36，4： | 1 |
| 20 | Fault detection of open-switch damage in voltage-fed PWM motor drive systems 显示文摘 | Ribeiro R L A Jacobina C B Silva E R C | 2003 | IEEE Transactions on Power Electronics2003，18，2： | 1 |
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