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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Low temperature operation and influence parameters on the cold start ability of portable PEMFCs显示文摘 | OSZCIPOK M ZEDDA M RIEMANN D | 2006 | Journal of Power Sources2006，154，24： | 1 |
| 3 | Nutrient limitation of phytoplankton biomass or growth rate- An experimental approach using marine enclosures显示文摘 | HEIN M RIEMANN B | 1995 | Journal of Experimental Marine Biology and Ecology1995，188，2： | 1 |
| 4 | In vitro femtosecond laser-assisted nanosurgery of porcine posterior capsule显示文摘 | Toropygin SG Krause M Riemann I | | 0，，： | 1 |
| 5 | Do periodic leg movements influence patients'perception of sleep quality显示文摘 | Hornyak M Riemann D Voderholzer U | | 0，，： | 1 |
| 6 | Functional and structural brain alterations in insomnia: implications for pathophysiology显示文摘 | Riemann D C Kloepfer M Berger | 2009 | Eur J Neurosci2009，29，9： | 1 |
| 7 | Outcomes of transconjunctival sutureless 25-gauge vitrectomy with silicone oil infusion显示文摘 | Riemann C Danielm M Foster RE Petersen MR | 2007 | Retina2007，27，23： | 1 |
| 8 | Nutrient limitation of phytoplankton biomass or growth rate : an experimental approach using marine enclosures 显示文摘 | Hein M Riemann B | 1995 | Journal of Experiment Marine Biology and Ecology1995，188，： | 1 |
| 9 | Sleep and depression-results frompsychobiogical studies:an overview显示文摘 | Riemann D Berger M Voderholzer U | 2001 | Biol Psychol2001，57，3： | 1 |
| 10 | Streptozotocin induced diabetes decreases conducted vasoconstrictor response in mouse cremaster arterioles显示文摘 | Rai A Riemann M Gustafsson F | 2008 | Horm Metab Res2008，40，9： | 1 |
| 11 | Sleep deprivation and growth-hormone secretion 显示文摘 | Lieb K Reineke M Riemann D | 2000 | Lancet2000，356，9247： | 1 |
| 12 | Alcohol ingestion influences the nocturnal cardio-respiratory activity in snoring and non-snoring males显示文摘 | Herzog M Riemann R | 2004 | Eur Arch Otorhinolaryngol2004，261，： | 1 |
| 13 | Start up and freezing processes in PEM fuel cells 显示文摘 | OSZCIPOK M HAKENJOS A RIEMANN D | 2007 | Fuel Cell2007，，2： | 1 |
| 14 | In vitro femtosecond laser-assisted nanosurgery of porcine poste- rior capsule 显示文摘 | Toropygin S G Krause M Riemann I | 2008 | J Cataract Refract Surg2008，34，12： | 1 |
| 15 | IL-12 suppression during experimental endotoxin tolerance:Dendritic cell loss and macrophage hyporesponsiveness显示文摘 | Wysocka M Robertson S Riemann H | 2001 | J Immunol2001，166，12： | 1 |
| 16 | Viral lysis of marine bacterioplankton : implications for organic matter cycling and bacterial clonal composition显示文摘 | Riemann L and Middelboe M | 2002 | Ophelia2002，56，： | 1 |
| 17 | Statistic analysis of operational influences on the cold start behaviour of PEM fuel cells显示文摘 | OSZCIPOK M RIEMANN D KRONENWETT U | 2005 | Journal of Power Sources2005，145，2： | 1 |
| 18 | Idemification of rice Allene (_):ride Cydase mutants and the function of jasrronate for defence against Magna- porthe oryzae显示文摘 | RIEMANN M HAGA K SHIMIZU T | 2013 | Plant J2013，74，2： | 1 |
| 19 | The treatments of chronic insomnia: a review of benzodiazepine receptor agonists and psychological and behavioral therapies显示文摘 | Riemann D Perlis M L | 2009 | Sleep Med Rev2009，13，3： | 1 |
| 20 | Viral lysis of marine bacterioplankton: implications for organic matter cycling and bacterial elonal composition 显示文摘 | Riemann L Middetboe M | 2002 | Ophelia2002，56，： | 1 |
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