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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet2010，，9730： | 3 |
| 4 | Hyperspectral versus multispectral data for estimating leaf area index in four different biomes显示文摘 | Kyu-Sung Lee Warren B Cohen Robert E Kennedy Thomas K Maiersperger Stith T Gower | 2004 | Remote Sensing of Environment2004，，3： | 2 |
| 5 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet . 2010 (9730)2010，，： | 2 |
| 6 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 7 | The Wilson disease gene: spectrum of mutations and their consequences 显示文摘 | Thomas G R Forbes J R Roberts E A | 1995 | Nat Genet1995，9，2： | 1 |
| 8 | Liquefaction of Autographa californica Nucleopolyhedrovirus-Infected Insects Is Dependent on the Integrity of Virus-Encoded Chitinase and Cathepsin Genes显示文摘 | Rachael E Hawtin Tamara Zarkowska Kevin Arnold Carole J Thomas Graham W Gooday Linda A King John A Kuzio Robert D Possee | 1997 | Virology1997，，： | 1 |
| 9 | Cloning and characterization of a novel polygalacturonase-encoding gene from Aspergillus parasiticus显示文摘 | Jeffrey W Cary Robert Brown Thomas E | 1995 | Gene1995，153，： | 1 |
| 10 | Bovine cumulus cell-oocyte gap junctional communication during in vitro maturation in response to manipulation of cell-specific cyclic adenosine 3,5monophosophate levels显示文摘 | Rebecca E Thomas David T Armstrong Robert B | 2004 | Biol Reprod2004，70，： | 1 |
| 11 | Using chlorine demand to predict TTHM and HAA9 formation显示文摘 | Daniel Dianchen Gang Robert L Segar Jr Thomas E Clevenger | 2002 | J AWWA2002，94，10： | 1 |
| 12 | Recognition of tetramethylenedisulfotetramine and related sulfamides by the brain GABA-gated chloride channel and a eyelodienesensitive monoclonal antibody 显示文摘 | Thomas E Alexander E K Robert F T | 1991 | Chem Res Toxicol1991，4，2： | 1 |
| 13 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet2010，，9730： | 1 |
| 14 | Maximizing the value of customer-sited PV systems using storage and controls显示文摘 | THOMAS HOFF E RICHARD Perez Robert MARAOLIS M | | 0，，81： | 1 |
| 15 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet2010，，9730： | 1 |
| 16 | The slab geometry laser-Part Ⅱ: thermal effects in a finite slab显示文摘 | Thomas J K John M E Robert L B | 1985 | IEEE J Quant Electr1985，21，8： | 1 |
| 17 | Lateral approach to the upper cervical spine for anterior fusion显示文摘 | Thomas E Whitesides Jr Robert P | 1966 | South Med J1966，59，8： | 1 |
| 18 | From words to literature in structural proteomics显示文摘 | Andrej S Robert G Thomas E | 2003 | Nature2003，422，2： | 1 |
| 19 | Lateral approach to the upper cervical spine for anterior fusion 显示文摘 | Thomas E Whitesides Jr Robert P | 1966 | South Med J1966，59，8： | 1 |
| 20 | NCSA' s world wide web server: design and performance 显示文摘 | THOMAS T KWAN ROBERT E MCGRATH DANIEL A REED | 1995 | IEEE Computer1995，11，： | 1 |
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