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| 1 | 在在母亲胎儿的接口的天生、适应的有免疫力的房间之间的不平衡发生在导致内毒素的 preterm 出生以前显示文摘Preterm 出生(PTB ) 是新生的病态和世界范围的死亡的领先的原因。到在母亲并且在母亲胎儿的接口的一个支持 inflammatory 状态的来自一个反煽动性的状态的转变在微生物引起导致 preterm 劳动的 pathophysiology 被含有。然而,房间哪个免疫者调停,是不清楚的这转变。我们假设了那在在母亲胎儿的接口的天生、适应的有免疫力的房间之间的不平衡将发生在微生物引起导致 preterm 劳动以前。用导致内毒素的 PTB 的一个确定的鼠科的模型,我们的结果证明在交货以前,有 CD4+ 的减小;在子宫的纸巾的规章的 T 房间(Tregs ) 。这减小被子宫的纸巾也不在脾连接到 Tregs 的一个减少的数字,也不到 IL10, CCL17,或 CCL22 的损害生产。到怀孕老鼠的内毒素管理不改变受动器 CD4+在母亲胎儿的接口的 T 房间。然而,它引起在 Tregs 之间的不平衡(CD4+并且 CD8+) ,受动器 CD8+在怒气的 T 房间,和 Th17 房间。另外,到怀孕老鼠的内毒素管理象丰富的 neutrophils 一样由子宫的纸巾导致 CCL2, CCL3, CCL17,和 CCL22 的过多的生产。在子宫的微型环境的这不平衡被象巨噬细胞和 MHC II+ 那样的少见的象 APC 一样房间伴随;neutrophils。一起,这些结果证明到怀孕老鼠的内毒素管理在母亲胎儿的接口引起在天生、适应的有免疫力的房间之间的不平衡。 | Marcia Arenas-Hernandez Roberto Romero Derek St Louis Sonia S Hassan Emily B Kaye Nardhy Gomez-Lopez | 2016 | Cellular & Molecular Immunology2016，13，4： | 6 |
| 2 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 3 | Management of hepatitis C in patients with chronic kidney disease显示文摘Hepatitis C virus(HCV) infection is highly prevalent among chronic kidney disease(CKD) subjects under hemodialysis and in kidney transplantation(KT) recipients, being an important cause of morbidity and mortality in these patients. The vast majority of HCV chronic infections in the hemodialysis setting are currently attributable to nosocomial transmission. Acute and chronic hepatitis C exhibits distinct clinical and laboratorial features, which can impact on managementand treatment decisions. In hemodialysis subjects, acute infections are usually asymptomatic and anicteric; since spontaneous viral clearance is very uncommon in this context, acute infections should be treated as soon as possible. In KT recipients, the occurrence of acute hepatitis C can have a more severe course, with a rapid progression of liver fibrosis. In these patients, it is recommended to use pegylated interferon(PEG-IFN) in combination with ribavirin, with doses adjusted according to estimated glomerular filtration rate. There is no evidence suggesting that chronic hepatitis C exhibits a more aggressive course in CKD subjects under conservative management. In these subjects, indication of treatment with PEG-IFN plus ribavirin relies on the CKD stage, rate of progression of renal dysfunction and the possibility of a preemptive transplant. HCV infection has been associated with both liver disease-related deaths and cardiovascular mortality in hemodialysis patients. Among those individuals, low HCV viral loads and the phenomenon of intermittent HCV viremia are often observed, and sequential HCV RNA monitoring is needed. Despite the poor tolerability and suboptimal efficacy of antiviral therapy in CKD patients, many patients can achieve sustained virological response, which improve patient and graft outcomes. Hepatitis C eradication before KT theoretically improves survival and reduces the occurrence of chronic graft nephropathy, de novo glomerulonephritis and post-transplant diabetes mellitus. | Roberto J Carvalho-Filho Ana Cristina CA Feldner Antonio Eduardo B Silva Maria Lucia G Ferraz | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 4 | Menopause and cognitive impairment:A narrative review of current knowledge显示文摘A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition. | Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva | 2021 | World Journal of Psychiatry2021，11，8： | 3 |
| 5 | Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C显示文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature. | Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva | 2012 | World Journal of Gastroenterology2012，18，2： | 3 |
| 6 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 7 | Specific genetic markers for wheat, spelt, and four wild relatives: Comparison of isozymes, RAPDs, and wheat microsatellites显示文摘 | Roberto G Dessislava S B Francois F | 2001 | Genome2001，44，4： | 1 |
| 8 | FMECA approachto product traceability in the food industry显示文摘 | Massimo B Maufizio B Roberto M | 2004 | Food Control2004，17，9： | 1 |
| 9 | Epidermal growth factor induced intracellular Ca2+ oscillations in microvascular endothelial cells显示文摘 | Francesco M Roberto B Simona T | 2003 | J Cell Physiol2003，194，2： | 1 |
| 10 | A cross-cultural examination of interpersonal communication motives in Mexico and the United States显示文摘 | Rubin Rebecca B Carlos Fernandez Collado and Roberto Hernandez-Sampieri | 1992 | International Journal of Intercultural Relations1992，16，2： | 1 |
| 11 | R&R blends as refrigerants显示文摘 | Sergio B Roberto C Laura F | 2004 | International Refrigeration and Air Conditioning Conference2004，，： | 1 |
| 12 | Effects of classroom noise on the speech perception of bilingual children learning in their second language: preliminary results 显示文摘 | Roberto B Enrico C | 2009 | Audiological Medicine2009，7，4： | 1 |
| 13 | A comparative study of the glucose,white blood cell count,interleukin-6,and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes 显示文摘 | Roberto R Yoon B H Moshe M el al | 1993 | Am J Obstet Gynecol1993，169，： | 1 |
| 14 | The mechanism of stochastic resonance显示文摘 | Roberto B Alfonso S Angelo V | 1981 | J Phys A:Math Gen1981，14，： | 1 |
| 15 | The late phase of preconditioning显示文摘 | Roberto B | 2000 | Grc Res2000，87，11： | 1 |
| 16 | Using weather ensemble predic- tions in electricity demand forecasting 显示文摘 | James W T Roberto B | 2003 | International Journal of Forecasting2003，，19： | 1 |
| 17 | Late recurrent capsular hematoma afteraugmentationmammaplasty:casereport 显示文摘 | Mauro S Euqenio F Roberto B | 2005 | Aesthetic Plast Surg2005，29，1： | 1 |
| 18 | Public perceptions of climate change as a human health risk: surveys of the United States, Canada and Malta 显示文摘 | Karen A Roberto D Peter B | 2010 | International Journal of Environmental Research and Public Health2010，，7： | 1 |
| 19 | Clinical impact of on-site cytopathology interpretation on endoscopic ultrasound-guided fine needle aspiration显示文摘 | Jason B Klapman Roberto Logrono Charles E Dye Irving Waxman | 2003 | The American Journal of Gastroenterology2003，，6： | 1 |
| 20 | Pathobiology of secondary immune thrombocytopenia显示文摘 | Cines D B Howard L Roberto S | 2009 | Semin Hematol2009，46，1： | 1 |
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