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| 1 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 2 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 3 | Halide Homogenization for High-Performance Blue Perovskite Electroluminescence显示文摘Metal halide perovskite light-emitting diodes(LEDs)have achieved great progress in recent years.However,bright and spectrally stable blue perovskite LED remains a significant challenge.Three-dimensional mixed-halide perovskites have potential to achieve high brightness electroluminescence,but their emission spectra are unstable as a result of halide phase separation.Here,we reveal that there is already heterogeneous distribution of halides in the as-deposited perovskite films,which can trace back to the nonuniform mixture of halides in the precursors.By simply introducing cationic surfactants to improve the homogeneity of the halides in the precursor solution,we can overcome the phase segregation issue and obtain spectrally stable single-phase blueemitting perovskites.We demonstrate efficient blue perovskite LEDs with high brightness,e.g.,luminous efficacy of 4.7,2.9,and 0.4 lmW^(-1) and luminance of over 37,000,9,300,and 1,300 cdm^(-2) for sky blue,blue,and deep blue with Commission Internationale de l’Eclairage(CIE)coordinates of(0.068,0.268),(0.091,0.165),and(0.129,0.061),respectively,suggesting real promise of perovskites for LED applications. | Lu Cheng Chang Yi Yunfang Tong Lin Zhu Gunnar Kusch Xiaoyu Wang Xinjiang Wang Tao Jiang Hao Zhang Ju Zhang Chen Xue Hong Chen Wenjie Xu Dawei Liu Rachel AOliver Richard HFriend Lijun Zhang Nana Wang Wei Huang Jianpu Wang | 2020 | Research2020，，1： | 4 |
| 4 | LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease显示文摘Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD. | Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 5 | Regulating the morphology of fluorinated non-fullerene acceptor and polymer donor via binary solvent mixture for high efficiency polymer solar cells显示文摘Fluorinated non-fullerene acceptors(NFAs) usually have planar backbone and a higher tendency to crystallize compared to their non-fluorinated counterparts, which leads to enhanced charge mobility in organic solar cells(OSCs). However, this selforganization behavior may result in excessive phase separation with electron donors and thereby deteriorate device efficiency.Herein, we demonstrate an effective approach to tune the molecular organization of a fluorinated NFA(INPIC-4 F), and its phase separation with the donor PBDB-T, by varying the casting solvent. A prolonged film drying time encourages the crystallization of INPIC-4 F into spherulites and consequently results in excessive phase separation, leading to a low device power conversion efficiency(PCE) of 8.1%. Contrarily, a drying time leads to fine mixed domains with inefficient charge transport properties,resulting in a moderate device PCE of 11.4%. An intermediate film drying time results in the formation of face-on π-π stacked PBDB-T and INPIC-4 F domains with continuous phase-separated networks, which facilitates light absorption, exciton dissociation as well as balanced charge transport towards the electrode, and achieves a remarkable PCE of 13.1%. This work provides a rational guide for optimizing the molecular ordering of NFAs and electron donors for high device efficiency. | Mengxue Chen Zhuohan Zhang Wei Li Jinlong Cai Jiangsheng Yu Emma L. K. Spooner Rachel C. Kilbride Donghui Li Baocai Du Robert S. Gurney Dan Liu Weihua Tang David G. Lidzey Tao Wang | 2019 | Science China Chemistry2019，62，9： | 2 |
| 6 | Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia显示文摘ObjectiveTo 在在检验生活和资源使用的质量的 17 所澳大利亚的疗养院的代表性的研究的 Australia.MethodsAs 部分住在疗养院的更老的成年人与认知功能和痴呆的诊断检验在心血管的系统药使用之间的协会,我们检验了在认知缺陷和心血管的药使用之间的协会(使用解剖治疗学的分类系统识别)用一般线性回归和逻辑 regressio 正在收到生活照顾的结束的人是包括的 excluded.ResultsParticipants 有一个平均数的 541 个居民 85.5 | Enwu Liu Suzanne M Dyer Lisa Kouladjian O'Donnell Rachel Milte Clare Bradley Stephanie L Harrison Emmanuel Gnanamanickam Craig Whitehead Maria Crotty | 2017 | Journal of Geriatric Cardiology2017，14，6： | 2 |
| 7 | Transmembrane semaphorin5B is proteolytically processed into a repulsive neural guidance cue显示文摘 | Kristen Browne Wenyan Wang Rachel Q. Liu Matthew Piva Timothy P. O’Connor | 2012 | Journal of Neurochemistry2012，，： | 1 |
| 8 | Genome-Scale Transcriptomic Insights into Early-Stage Fruit Development in Woodland Strawberry Fragaria vesca[W]显示文摘 | Chunying Kang Omar Darwish Aviva Geretz Rachel Shahan Nadim Alkharouf Zhongchi Liu | 2013 | The Plant Cell2013，，6： | 1 |
| 9 | Quantum spin hall insulators with interactions and lattice anisotropy 显示文摘 | Wu W Rachel S Liu W M | 2012 | Physical Review B2012，85，20： | 1 |
| 10 | A method to weight three categories of adaptive thermal comfort显示文摘 | Jing Liu Runming Yao Rachel McCloy | 2012 | Energy and Buildings2012，47，： | 1 |
| 11 | Role of hypoxia inducible factor 1α in cobalt nanoparticle induced cytotoxicity of human THP-1 macrophages显示文摘Cobalt is one of the main components of metal hip prostheses and cobalt nanoparticles(CoNPs)produced from wear cause inflammation,bone lyses and cytotoxicity at high concentrations.Cobalt ions mimic hypoxia in the presence of normal oxygen levels,and activate hypoxic signalling by stabilising hypoxia inducible transcription factor 1α(HIF1α).This study aimed to assess in vitro the functional role of HIF1αin CoNP induced cellular cytotoxicity.HIF1α,lysosomal pH,tumour necrosis factorαand interleukin 1βexpression were analysed in THP-1 macrophages treated with CoNP(0,10 and 100μg/mL).HIF1αknock out assays were performed using small interfering RNA to assess the role of HIF1αin CoNP-induced cytotoxicity.Increasing CoNP concentration increased lysosomal activity and acidity in THP-1 macrophages.Higher doses of CoNP significantly reduced cell viability,stimulated caspase 3 activity and apoptosis.Reducing HIF1αactivity increased the pro-inflammatory activity of tumour necrosis factorαand interleukin 1β,but had no significant impact on cellular cytotoxicity.This suggests that whilst CoNP promotes cytotoxicity and cellular inflammation,the apoptotic mechanism is not dependent on HIF1α. | Wendy Rachel Francis Zhao Liu Sian E Owens Xiao Wang Huaming Xue Alex Lord Venkateswarlu Kanamarlapudi Zhidao Xia | 2021 | Biomaterials Translational2021，2，2： | 1 |
| 12 | Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity显示文摘 | Ying Wang Xi-Yu Ke Jasmeet Singh Khara Priti Bahety Shaoqiong Liu See Voon Seow Yi Yan Yang Pui Lai Rachel Ee | 2013 | Biomaterials2013，，： | 1 |
| 13 | A practical reference for studying meiosis in the model ciliate Tetrahymena thermophila显示文摘Meiosis is a critical cell division program that produces haploid gametes for sexual reproduction.Abnormalities in meiosis are often causes of infertility and birth defects(e.g.,Down syndrome).Most organisms use a highly specialized zipper-like protein complex,the synaptonemal complex(SC),to guide and stabilize pairing of homologous chromosomes in meiosis.Although the SC is critical for meiosis in many eukaryotes,there are organisms that perform meiosis without a functional SC.However,such SC-less meiosis is poorly characterized.To understand the features of SC-less meiosis and its adaptive significance,the ciliated protozoan Tetrahymena was selected as a model.Meiosis research in Tetrahymena has revealed intriguing aspects of the regulatory programs utilized in its SC-less meiosis,yet additional efforts are needed for obtaining an in-depth comprehension of mechanisms that are associated with the absence of SC.Here,aiming at promoting a wider application of Tetrahymena for meiosis research,we introduce basic concepts and core techniques for studying meiosis in Tetrahymena and then suggest future directions for expanding the current Tetrahymena meiosis research toolbox.These methodologies could be adopted for dissecting meiosis in poorly characterized ciliates that might reveal novel features.Such data will hopefully provide insights into the function of the SC and the evolution of meiosis from a unique perspective. | Miao Tian Xia Cai Yujie Liu Mingmei Liucong Rachel Howard-Till | 2022 | Marine Life Science & Technology2022，4，4： | 1 |
| 14 | Reduced cardiac output is associated with decreased mitochondrial efficiency in the non-ischemic ventricular wall of the acute myocardial-infarcted dog显示文摘心脏性的吃惊是在与尖锐心肌的梗塞(MI ) 就医的病人之中的死亡的领先的原因。为尖锐的泵失败理解机制因此是重要的。这研究的目的是在一个尖锐 MI 狗模型检验是否 mitochondrial 在 non-ischemic 墙区域以内的简历精力充沛的功能与泵失败被联系。前面的 MI 经由左前面的下降的结扎(男孩) 在狗被生产冠的动脉,那导致了大约 30% 左室的墙的一种犯尺寸。解开的血液动力学的地位, mitochondrial 功能,免费激进的生产和 mitochondrial 的大小蛋白质 3 (UCP3 ) 表示在 24 h 时期上被决定。血液动力学的大小揭示了 >
在在 24 h 帖子梗塞的心脏的输出的 50% 减小什么时候与基线相比。活体检视样品在尖锐梗塞期间从以后的 non-ischemic 墙被获得。当与在内的 ADP/O 比率相比一样有或没有十六酸酸(PA ) 取样时,为从在 6 h 和 24 h 的 non-ischemic 心肌层的孤立的线粒体的 ADP/O 比率被减少。GTP 抑制(PA ) 刺激了在从 non-ischemic 墙的孤立的线粒体的 4 呼吸在 6 h 和 24 h 增加了 7% 和 33% 的状态梗塞以后分别地什么时候与相比假冒并且梗塞前样品。这将建议线粒体被解开,这被从这些一样的活体检视样品在西方的污点上观察的 UCP3 表示的联系增加支持。从电子测量的冠的湾穴的血样品顺磁的回声(EPR ) 方法在 6 h 和 24 h 在基线上在反应的氧种类(ROS ) 显示出增加梗塞以后。在结论, mitochondrial 由于尖锐梗塞的简历精力充沛的 ADP/O 比率在 non-ischemic 墙以内是反常的。线粒体看起来精力充沛地被解开,这与衰退被联系泵功能。免费激进的生产可以与解开的正式就职被联系在线粒体的蛋白质。 | Zakaria A Almsherqi Craig S McLachlan Malgorzata B Slocinska Francis E Sluse Rachel Navet Nikolai Kocherginsky Iouri Kostetski Dong-Yun Shi Shan-Lin Liu Peter Mossop Yuru Deng | 2006 | Cell Research2006，16，3： | 1 |
| 15 | Incorporating mesopelagic fish into the evaluation of conservation areas for marine living resources under climate change scenarios显示文摘Mesopelagic fish(meso-fish)are central species within the Southern Ocean(SO).However,their ecosystem role and adaptive capacity to climate change are rarely integrated into protected areas assessments.This is a pity given their importance as crucial prey and predators in food webs,coupled with the impacts of climate change.Here,we estimate the habitat distribution of nine meso-fish using an ensemble model approach(MAXENT,random forest,and boosted regression tree).Four climate model simulations were used to project their distribution under two representative concentration pathways(RCP4.5 and RCP8.5)for short-term(2006–2055)and long-term(2050–2099)periods.In addition,we assess the ecological representativeness of protected areas under climate change scenarios using meso-fish as indicator species.Our models show that all species shift poleward in the future.Lanternfishes(family Myctophidae)are predicted to migrate poleward more than other families(Paralepididae,Nototheniidae,Bathylagidae,and Gonostomatidae).In comparison,lanternfishes were projected to increase habitat area in the eastern SO but lose area in the western SO;the opposite was projected for species in other families.Important areas(IAs)of meso-fish are mainly distributed near the Antarctic Peninsula and East Antarctica.Negotiated protected area cover 23% of IAs at present and 38%of IAs in the future(RCP8.5,long-term future).Many IAs of meso-fish still need to be included in protected areas,such as the Prydz Bay and the seas around the Antarctic Peninsula.Our results provide a framework for evaluating protected areas incorporating climate change adaptation strategies for protected areas management. | Shuhao Liu Yang Liu Katharina Teschke Mark AHindell Rachel Downey Briannyn Woods Bin Kang Shuyang Ma Chi Zhang Jianchao Li Zhenjiang Ye Peng Sun Jianfeng He Yongjun Tian | 2024 | Marine Life Science & Technology2024，6，1： | 0 |
| 16 | Identification of genes preferentially expressed in wild strawberry receptacle fruit and demonstration of their promoter activities显示文摘Fragaria vesca(F.vesca),the wild strawberry,is a diploid model for the commercial,octoploid strawberry as well as other members of the economically relevant Rosaceae family.Unlike the fruits of tomato and Arabidopsis,the fleshy fruit of strawberry is unique in that it is derived from the floral receptacle and has an external seed configuration.Thus,identification and subsequent characterization of receptacle-expressed genes may shed light on novel developmental processes or provide insight into how developmental regulation differs between receptacle-derived and ovary-derived fruits.Further,since fruit and flower tissues are the last organs to form on a plant,the development of receptacle fruitspecific promoters may provide useful molecular tools for research and application.In this work,we mined previously generated RNA-Seq datasets and identified 589 genes preferentially expressed in the strawberry receptacle versus all other profiled tissues.Promoters of a select subset of the 589 genes were isolated and their activities tested using a GUS transcriptional reporter.These promoters may now be used by the F.vesca research community for a variety of purposes,including driving expression of tissue-specific reporters,RNAi constructs,or specific genes to manipulate fruit development.Further,identified genes with receptacle-specific expression patterns,including MADS-Box and KNOX family transcription factors,are potential key regulators of fleshy fruit development and attractive candidates for functional characterization. | Rachel Shahan Dongdong Li Zhongchi Liu | 2019 | Horticulture Research2019，6，1： | 0 |
| 17 | Singing in the Viennese Woods显示文摘本文作者刘泠(Rachel Liu)曾就读英国曼彻斯特大学。2003年的5月,她在维也纳的森林以高唱国歌的方式抒发了自己的爱国情怀。配文照片为本文作者在维也纳和阿尔卑斯山区。 | Rachel Liu | 2005 | 英语沙龙(高中)2005，0，1： | 0 |
| 18 | Non-fullerene acceptor fibrils enable efficient ternary organic solar cells with 16.6% efficiency显示文摘Optimizing the components and morphology within the photoactive layer of organic solar cells(OSCs)can significantly enhance their power conversion efficiency(PCE).A new A-D-A type non-fullerene acceptor IDMIC-4F is designed and synthesized in this work,and is employed as the third component to prepare high performance ternary solar cells.IDMIC-4F can form fibrils after solution casting,and the presence of this fibrillar structure in the PBDB-T-2F:BTP-4F host confines the growth of donors and acceptors into fine domains,as well as acting as transport channels to enhance electron mobility.Single junction ternary devices incorporating 10 wt%IDMIC-4F exhibit enhanced light absorption and balanced carrier mobility,and achieve a maximum PCE of 16.6%compared to 15.7%for the binary device,which is a remarkable efficiency for OSCs reported in literature.This non-fullerene acceptor fibril network strategy is a promising method to improve the photovoltaic performance of ternary OSCs. | Donghui Li Xiaolong Chen Jinglong Cai Wei Li Mengxue Chen Yuchao Mao Baocai Du Joel A.Smith Rachel C.Kilbride Mary E.O'Kane Xue Zhang Yuan Zhuang Pang Wang Hui Wang Dan Liu Richard A.L.Jones David G.Lidzey Tao Wang | 2020 | Science China Chemistry2020，63，10： | 0 |
| 19 | Three X-ray flares near primary eclipse of the RS CVn binary XY UMa显示文摘We report on an archival X-ray observation of the eclipsing RS CVn binary XY UMa(P_(orb) ≈0.48 d). In two Chandra ACIS observations spanning 200 ks and almost five orbital periods, three flares occurred. We find no evidence for eclipses in the X-ray flux. The flares took place around times of primary eclipse, with one flare occurring shortly(< 0.125 P_(orb)) after a primary eclipse, and the other two happening shortly(< 0.05 P_(orb)) before a primary eclipse. Two flares occurred within roughly one orbital period(?φ≈1.024 P_(orb)) of each other. We analyze the light curve and spectra of the system, and investigate coronal length scales during both quiescence and flares, as well as the timing of the flares. We explore the possibility that the flares are orbit-induced by introducing a small orbital eccentricity, which is quite challenging for this close binary. | Hang Gong Rachel Osten Thomas Maccarone Fabio Reale Ji-Feng Liu Paul A. Heckert | 2016 | Research in Astronomy and Astrophysics2016，16，8： | 0 |
| 20 | Influence of Halide Choice on Formation of Low-Dimensional Perovskite Interlayer in Efficient Perovskite Solar Cells显示文摘Recent advances in heterojunction and interfacial engineering of perovskite solar cells(PSCs)have enabled great progress in developing highly efficient and stable devices.Nevertheless,the effect of halide choice on the formation mechanism,crystallography,and photoelectric properties of the lowdimensional phase still requires further detailed study.In this work,we present key insights into the significance of halide choice when designing passivation strategies comprising large organic spacer salts,clarifying the effect of anions on the formation of quasi-2D/3D heterojunctions.To demonstrate the importance of halide influences,we employ novel neo-pentylammonium halide salts with different halide anions(neoPAX,X=I,Br,or Cl).We find that regardless of halide selection,iodide-based(neoPA)_(2)(FA)_((n-1))PbnI_((3n+1))phases are formed above the perovskite substrate,while the added halide anions diffuse and passivate the perovskite bulk.In addition,we also find the halide choice has an influence on the degree of dimensionality(n).Comparing the three halides,we find that chloride-based salts exhibit superior crystallographic,enhanced carrier transport,and extraction compared to the iodide and bromide analogs.As a result,we report high power conversion efficiency in quasi-2D/3D PSCs,which are optimal when using chloride salts,reaching up to 23.35%,and improving long-term stability. | Xueping Liu Thomas Webb Linjie Dai Kangyu Ji Joel A.Smith Rachel C.Kilbride Mozhgan Yavari Jinxin Bi Aobo Ren Yuanyuan Huang Zhuo Wang Yonglong Shen Guosheng Shao Stephen J.Sweeney Steven Hinder Hui Li David G.Lidzey Samuel D.Stranks Neil C.Greenham S.Ravi P.Silva Wei Zhang | 2022 | Energy & Environmental Materials2022，5，2： | 0 |
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