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| 1 | The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway显示文摘Inflammasomes 为维持肠的动态平衡是重要的,并且 dysbiosis 贡献煽动性的肠疾病(IBD ) 的病理并且为 colorectal 癌症增加风险。Inflammasome 缺点贡献长期的肠的发炎并且在老鼠增加危险性到大肠炎。然而,在黑瘤 2 不在的 inflammasome 传感器(AIM2 ) 通过 DNA 依赖的蛋白质 kinase 和 Akt 小径以一种 inflammasome 独立的方式免于 colorectal 癌症。然而,在 IBD 和 colorectal 癌症的早阶段的 AIM2 inflammasome 的角色留下不清楚。这里,我们证明 AIM2 inflammasome 在肠有一个保护的角色。在稳定的状态期间, Aim2 删除导致 IL-18 分泌物的损失,在肠的上皮的房间和 STAT3 依赖的抗菌剂肽(安培) 的作为结果的损失的 IL-22 有约束力的蛋白质(IL-22BP ) 的抑制 Reg3β并且 Reg3γ,它支持连接 dysbiosis 的大肠炎。在葡聚糖硫酸盐期间导致钠的大肠炎,不正常的 IL-18/在 Aim2 −/− 老鼠的 IL-22BP 小径支持过多的 IL-22 生产和提高的 STAT3 激活。Aim2 −/− 鼠标进一步在提高的 Reg3b 和 Reg3g 表示造成的大肠炎的分辨率期间展出持续 STAT3 和 Akt 激活。这恋职的机制支持肠的地窟房间的增长并且多半在 Aim2 −/− 老鼠的危险性贡献最近描述的增加到 colorectal 癌症。一起,我们的结果在通过 IL-18/ 的规定阻止 dysbiosis 和肠的发炎为 AIM2 inflammasome 表明一个中央角色; IL-22BP/ IL-22 和 STAT3 小径和精选安培的表示。 | Rojo A Ratsimandresy Mohanalaxmi Indramohan Andrea Dorfleutner Christian Stehlik | 2017 | Cellular & Molecular Immunology2017，14，1： | 27 |
| 2 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 3 | Android fat ditribution as predictor of severity in acute pancreatitis 显示文摘 | Mery CM Rubio V Duarte - Rojo A | 2002 | Pancreatology2002，2，6： | 1 |
| 4 | The role of neuroimmunomodulation in Alzheimer′s disease显示文摘 | MACCIONI R B ROJO L E FERNNDEZ J A | 2009 | Ann N Y Acad Sci2009，1153，： | 1 |
| 5 | Expression and clinical significance of pepsinogen C in epithelial ovarian carcinomas显示文摘 | Rojo J V Merino A M Gonzalez L O | 2002 | Eur J Obstet Gynecol Reprod Biol2002，104，1： | 1 |
| 6 | Cervical cancer: Current view of its epidemiology and risk factors显示文摘 | Torres Lobaton A Rojo Herrera G Torres Rojo A | 2004 | Ginecol Obstet Mex2004，72，9： | 1 |
| 7 | Efficacy of second-generation-antipsychotics in the treatment of negative symptoms of schizophrenia:a meta-analysis of randomized clinical trials显示文摘 | Darbà J Minoves A Rojo E | 2011 | Rev Psiquiatr Salud Ment2011，4，3： | 1 |
| 8 | Macrocyclic peptidomimetic inhibitors of fl-secretase ( BACE ) : First X-ray structure of a macrocyclic peptidomimetic-BACE complex 显示文摘 | ROJO I MARTIN J A BROUGHTON H | 2006 | Bioorg Med Chem Lett2006，16，1： | 1 |
| 9 | Creep response of thixotropic ambient temperature cure adhesives measured by DMTA in static tension and shear显示文摘 | Roseley A S M Rojo E Ansell M P | 2011 | International Journal of Adhesion and Adhesives2011，31，6： | 1 |
| 10 | Formation process of LiSn2(PO4)3, a monoclinically distorted NASI- CON-type stmcture显示文摘 | Martinez A Rojo J M Iglesias J E | 1994 | Chemistry of materials1994，6，10： | 1 |
| 11 | The effect of innovation policy on SMEs' employment and wages in Argentina 显示文摘 | Castillo V Maffioli A Rojo S | 2014 | Small Business Economics2014，42，2： | 1 |
| 12 | Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism显示文摘 | Jazwa A Rojo AI Innamorato NG | 2011 | Antioxid Redox Signal2011，14，： | 1 |
| 13 | Expression of p95 HER-2,a truncated form of the HER-2 receptor,and response to anti-HER-2 therapies in breast cancer显示文摘 | Scaltriti M Rojo F Ocana A | | 0，，08： | 1 |
| 14 | Nuclear NF-κB/p65 expression and response to neoadjuvant chemotherapy in breast cancer显示文摘 | Jones RL Rojo F A'Hern R | | 0，，02： | 1 |
| 15 | Neuroinflam- marion: implications for the pathogenesis and molecular diag- nosis of Alzheimer's disease显示文摘 | Rojo LE Ferndndez ]A Maceioni AA | 2008 | Arch Med Res2008，39，： | 1 |
| 16 | lndentification of Cryptosporidium parvum occyst/ sporozite antigens recognized by infected and hyperimmue lambs显示文摘 | Ortega L M Troncoso J M Rojo F A | 1994 | Vet Para1994，53，： | 1 |
| 17 | Nuclear NF-KB/p65 expression and response to neoadjuvant chemotherapy in breast cancer显示文摘 | Jones RL Rojo F A'Hem R | 2011 | J Clin Pathol2011，64，2： | 1 |
| 18 | Three different techniques for mandibular reconstruction after hemimandibulectomy显示文摘 | Inigo F Rojo R Ysunza A | 1997 | J Craniofac Surg1997，8，1： | 1 |
| 19 | High TGFbeta-Smadactivity confers poor prognosis in glioma patients andpromotes cell proliferation depending on the methylation ofthe PDGF-B gene显示文摘 | Bruna A Darken R S Rojo F | 2007 | Cancer Cell2007，11，2： | 1 |
| 20 | Altered CBreceptor-signaling in prefrontal cortex from an animal model ofdepression is reversed by chronic fluoxetine显示文摘 | Rodriguez-Gaztelumendi A Rojo ML Pazos A | 2009 | J Neurochemistry2009，108，6： | 1 |
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