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| 1 | Microbiome as mediator: Do systemic infections start in the gut?显示文摘The intestinal microbiome is emerging as a crucial mediator between external insults and systemic infections. New research suggests that our intestinal microorganisms contribute to critical illness and the development of non-gastrointestinal infectious diseases.Common pathways include a loss of fecal intestinal bacterial diversity and a disproportionate increase in toxogenic bacterial species. Therapeutic interventions targeting the microbiome- primarily probiotics- have yielded limited results to date. However, knowledge in this area is rapidly expanding and microbiome-based therapy such as short-chain fatty acids may eventually become a standard strategy for preventing systemic infections in the context of critical illness. | Melissa Latorre Suneeta Krishnareddy Daniel E Freedberg | 2015 | World Journal of Gastroenterology2015，21，37： | 5 |
| 2 | Real-time multiplex PCR assay to quantify hepatitis C virus RNA in peripheral blood mononuclear cells显示文摘 | Paolo Pugnale Patrizia Latorre Christine Rossi Katia Crovatto Valerio Pazienza Andrea De Gottardi Francesco Negro | 2005 | Journal of Virological Methods2005，，2： | 3 |
| 3 | Isolation, screening and identifi cation of Bacillus spp. as direct-fed microbial candidates for aflatoxin B_1 biodegradation显示文摘Objective: To evaluate the ability of Bacillus spp. as direct-fed microbials(DFM) to biodegrade al atoxin B1(AFB1) by using an in vitro digestive model simulating in vivo conditions.Methods: Sixty-nine Bacillus isolates were obtained from intestines, and soil samples were screened by using a selective media method against 0.25 and 1.00 μg/m L of AFB1 in modii ed Czapek-Dox medium. Plates were incubated at 37 °C and observed every two days for two weeks. Physiological properties of the three Bacillus spp. candidates were characterized biochemically and by 16 S r RNA sequence analyzes for identii cation. Tolerance to acidic p H, osmotic concentrations of Na Cl, bile salts were tested, and antimicrobial sensitivity proi les were also determined. Bacillus candidates were individually sporulated by using a solid fermentation method and combined. Spores were incorporated into 1 of 3 experimental feed groups: 1) Negative control group, with unmedicated starter broiler feed without AFB1; 2) Positive control group, with negative control feed contaminated with 0.01% AFB1; 3) DFM treated group, with positive control feed supplemented with 109 spores/g. After digestion time(3:15 h), supernatants and digesta were collected for high-performance liquid chromatography l uorescence detection analysis by triplicate.Results: Three out of those sixty-nine DFM candidates showed ability to biodegrade AFB1 in vitro based on growth as well as reduction of l uorescence and area of clearance around each colony in modii ed Czapek-Dox medium which was clearly visible under day light after 48 h of evaluation. Analysis of 16S-DNA identii ed the strains as Bacillus amyloliquefaciens, Bacillus megaterium and Bacillus subtilis. The three Bacillus strains were tolerant to acidic conditions(p H 2.0), tolerant to a high osmotic pressure(Na Cl at 6.5%), and were able to tolerate 0.037% bile salts after 24 h of incubation. No signii cant dif erences(P > 0.05) were observed in the concentrations of AFB1 in neither the supernatants nor digesta samples evaluated by highperformance liquid chromatography with l uorescence detection between positive control or DFM treated groups. Conclusions: In vitro digestion time was not enough to confirm biodegradation of AFB1. Further studies to evaluate the possible biodegradation ef ects of the BacillusDFM when continuously administered in experimentally contaminated feed with AFB1, are in progress. | Rosario Galarza-Seeber Juan David Latorre Xochitl Hernandez-Velasco Amanda Drake Wolfenden Lisa Renee Bielke Anita Menconi Billy Marshall Hargis Guillermo Tellez | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，9： | 3 |
| 4 | Epidemiology of upper gastrointestinal symptoms in Brazil(Epi Gastro):A population-based study according to sex and age group显示文摘AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease(GERD)and dyspepsia in South America.METHODS:A telephone survey was conducted among adult owners of land-based telephones in S?o Paulo,Brazil,using previously validated computer-assisted sampling and survey protocols.The Portugueselanguage survey included(1)sociodemographic characteristics(e.g.,weight,height,smoking)and comorbidities;(2)dietary habits;(3)presence of symptoms consistent with GERD or dyspepsia within the prior 3mo;and(4)use of medications and other therapies to manage symptoms.Data were stratified post-hoc into three homogeneous geographical regions of S?o Paulo according to the Social Exclusion Indices of the districts and postal codes.Survey response data from each respondent were weighted by the numbers of adults and landline telephones in each household.The analyses were weighted to account for sampling design and to be representative of the S?o Paulo population according to city census data.RESULTS:Among 4570 households contacted,an adult from 3050(66.7%)agreed to participate.The nonresponse rate was 33.3%.The mean(SE)respondent age was 42.6(16.0)years.More than half of all respondents were women(53.1%),aged 18 through 49 years(66.7%),married or cohabitating(52.5%),and/or above normal-weight standards(i.e.,35.3%overweight and 16.3%obese).A total of 26.5%of women were perimenopausal.More than 20%of respondents reported highly frequent symptoms consistent with GERD(e.g.,gastric burning sensation=20.8%)or dyspepsia(e.g.,abdominal swelling/distension=20.9%)at least once per month.Prevalences of these symptoms were significantly(approximately 1.5-to 2.0-fold)higher among women than men but did not vary significantly as a function of advancing age.For instance,14.1%of women reported that they experienced stomach burning(symptom of GERD)at least twice per week,compared to 8.4%of men(P=0.012 byχ2 test).A total of 15.7%of women reported that they experienced abdominal swelling(symptom of dyspepsia)at least twice per week,compared to 6.4%of men(P<0.001byχ2 test).Despite frequent manifestations of GERD or dyspepsia,most(≥90%)respondents reported that they neither received prescription medications fromphysicians,nor took behavioral measures(e.g.,dietary modifications),to manage symptoms.CONCLUSION:Symptoms consistent with dyspepsia and GERD are prevalent in Brazil and represent major public-health and clinical challenges. | Maria do Rosário Dias de Oliveira Latorre Aline Medeiros da Silva Décio Chinzon Jaime N Eisig Telma RP Dias-Bastos | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 5 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 6 | Calciumactivated potassium channels 显示文摘 | Vergara C Latorre R Marrion N V | 1998 | Curr Opin Neurobiol1998，8，： | 1 |
| 7 | Reducing fishing vessel fuel con sumption and NO emissions 显示文摘 | LATORRE R | 2001 | Ocean Engineer- ing2001，，8： | 1 |
| 8 | Calcium- activated potassium channels 显示文摘 | Vergara C Latorre R Marrion NV | 1998 | Curr Opin Neurobi- ol1998，8，3： | 1 |
| 9 | Determination of busulfan in human plasma using high-performance liquid chromatography with pre-column derivatization and fluorescence detection显示文摘 | Peris JE Latorre JA Castel V | | 0，，： | 1 |
| 10 | Autoantibodies Against the Fibrinolytic Receptor, Annexin A2, in Cerebral Venous Thrombosis显示文摘 | Gabriela Cesarman-Maus Carlos Cantú-Brito Fernando Barinagarrementeria Rosario Villa Elba Reyes Jorge Sanchez-Guerrero Katherine A. Hajjar Ethel Garcia Latorre | 2011 | Stroke2011，，2： | 1 |
| 11 | The relationship within and between production performance and meat quality characteristics in pigs from three different genetic lines显示文摘 | Latorre M A Pomar C Faucitano L | 2008 | Livestock Science2008，115，23： | 1 |
| 12 | The contributions and consequences of simulation tools and digital mock-ups on design and production as applied to the automobile and aeronautics industries 显示文摘 | Souad Latorre Jean-Marc Pointer | 2008 | International Journal of Automotive Technology and Management2008，8，3： | 1 |
| 13 | Interferon-gamma release assays in the detection of latent tuberculosis infection in patients with inflammatory arthritis scheduled for anti-tumour necrosis factor treatment显示文摘 | Minguez S Latorre I Mateo L | 2012 | Clin Rheumatol2012，31，： | 1 |
| 14 | Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain显示文摘 | Bertolino A Blasi G Latorre V Rubino V Rampino A Sinibaldi L | | 0，，15： | 1 |
| 15 | Ptaquilo- side reduces NK cell activities by enhancing metallothio- nein expression, which is prevented by selenium显示文摘 | Latorre A O Caniceiro B D Fukumasu H | 2013 | Tox- icology2013，304，： | 1 |
| 16 | Epithelial ovarian cancer:second and third line chemotherapy (review)显示文摘 | Latorre A Elena MD Catino A | 2002 | Int J oncol2002，21，1： | 1 |
| 17 | Occurrence of resistant strains of Botrytis cinerea to anilinopyrimidine fungicides in table grapes in Chile显示文摘 | Latorre B A Spadaro I Rioja M E | 2002 | Crop Protection2002，21，10： | 1 |
| 18 | Occurrence of resistant strains of Botrytis cinerea to anilinopyrimidine fungicides in table grapes in Chile显示文摘 | LATORR B A SPADARO I RIOJA M E | 2002 | Crop Protection2002，21，10： | 1 |
| 19 | Neonatal circumcisions performed by pedi- atric residents : implementation of a training program显示文摘 | Chandran L Latorre P | 2002 | Ambul Pe- diatr2002，2，6： | 1 |
| 20 | Prefrontal dysfunction in schizophrenia controlling for COMT Val 158Met genotype and working memory performance显示文摘 | Bertolino A Caforio G Petruzzella V Latorre V Rubino V Dimalta S | | 0，，： | 1 |
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