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	题名	作者	年代	出处	被引量
1	Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option.	Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres	2012	World Journal of Gastroenterology2012，18，25：	5
2	Clustering gene expression patterns显示文摘	Ron S Zohar Y	1999	Joumal of Computational Biology1999，6，34：	1
3	PCR technology for screening and quantification of genetically modified organisms (GMOs) 显示文摘	HOLST-JENSEN A RONNING S B LOVSETH A	2003	Anal Bioanal Chem2003，375，8：	1
4	PCR Tecnology for Screening and Quantification of Genetically Modified Organisms(GMO)显示文摘	Jensen A H Ronning S B Lovseth A	2003	Anal Bional Chem2003，375，：	1
5	Manipulations of AchE gene expression suggest noncatalytive of acetycholiesterase in the functioning of mammailian photoreceptors but not in retinal degeneration显示文摘	Ron S B Mitra G Anat L	1999	Molecular Brain Res1999，71，1：	1
6	Chitosan in hibits growth of spoilage micro-organisms in chilled pork products显示文摘	Satnam S Ron B Sibel R		0，，2：	1
7	PCR technol- ogy for screening and quantification of genetically modified or- ganisms (GMOs)显示文摘	Holst-Jensen A Ronning S B Lovseth A	2003	Analytical and Bioanalytical Chemistry2003，375，8：	1
8	Event specific real-time quantitative PCR for genetically modified Bt11 maize (Zea mays)显示文摘	ROnning S B Vatilingom M Berdal K G	2003	European Food Research Technology2003，216，：	1
9	Use of high pressure to reduce cook loss and improve texture of low-salt beef sausage batters显示文摘	Anita L S Aarti B T Ron K T	2009	Innovative Food Science & Emerging Technologies2009，10，4：	1
10	Insertion of Tellurium into an alkylpentaeak bonylmanganese complex and a conrenient New Route to Mangaese Telluride显示文摘	Katherine McGregor Glen B Deacon Ron S Dickson	1990	J Chem S Da1990，，19：	1
11	Differences in number and activity of peripheral natural killer cells in primary versus secondary recurrent miscarriage 显示文摘	Keren S Shamgar B Ron L	2003	Fertil Steril2003，80，：	1
12	Additional aroma components of honeydew melon显示文摘	RON G B RICHARD M S LOUISA C	1982	J Agric Food Chem1982，30，6：	1
13	Degradation kinetics of an aged hydrocarbon-contaminated soil显示文摘	MALETI? S DALMACIJA B RON?EVI? S	2009	Water Air & Soil Pollution2009，202，：	1
14	Use of high pressure to reduce cook loss and improve texture of low-salt beef sausage batters显示文摘	ANITA L S AARTI B T RON K T	2009	Innovative Food Science and Emerging Technologies2009，10，4：	1
15	Chitosan inhibits growth of spoilage micro-organisms in chilled pork products 显示文摘	Satnam S Ron B Sibel R	2002	Food Microbiology2002，19，2：	1
16	Adult stromal cells derived from human adipose tissue provoke pancreatic cancer cell death both in vitro and in vivo显示文摘	Cousin B Ravet E Poglio S De Toni F Bertuzzi M Lulka H Touil I André M Grolleau JL Péron JM Chavoin JP Bourin P Pénicaud L Casteilla L Buscail L Cordelier P		0，，：	1
17	Use of highpressure to reduce cook loss and improve texture of low-salt beef sausage batters 显示文摘	Anita L S Aarti B T Ron K T	2009	Innovative Food Science & Emerging Technologies2009，10，4：	1
18	Event specific real-time quantitative PCR for genetically modified Bt11 maize ( Zea mays ) 显示文摘	Ronning S B Vaitilingom M Berdal K G	2003	Euro Food Res Technol2003，216，4：	1
19	PCR technology for screening and quantification of genetically modified organisms ( GMOs ) 显示文摘	Holst-Jensen A Ronning S B Lcvseth A	2003	Anal Bioanal Chem2003，375，8：	1
20	Event specific real-time quantitative PCR for genetically modified Btll maize ( Zea mays) 显示文摘	Ronning S B Vaitilingom M Berdal K G	2003	European Food Research and Technology2003，216，：	1

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