|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High-precision measurement of mercury isotope ratios of atmospheric deposition over the past 150 years recorded in a peat core taken from Hongyuan, Sichuan Province, China显示文摘High-precision 210Pb dating technology was applied to a peat core with a time span of about 150 years that was taken from Hongyuan, Sichuan Province, China. The concentrations of total mercury (Hg) and stable isotope compositions of mercury in the peat core were measured using a LUMEX 915 instrument and multi-collector inductively coupled plasma mass spectrometer, respectively. Total mercury (Hg) concentrations in the peat core had a clearly increasing trend from the bottom to top of the core while δ 202Hg values (relative to NIST 3133) of peat had a decreasing trend. The total mercury (Hg) concentration varied from 16.7 to 101.3 ng/g and the δ 202Hg values ranged from –0.44‰± 0.14‰ to –1.45‰± 0.22‰. We clearly show that the study area experienced mercury pollution after the industrial revolution, and the mercury emitted from natural sources and anthropogenic sources had different Hg isotope signatures. | SHI WenFang FENG XinBin ZHANG Gan MING LiLi YIN RunSheng ZHAO ZhiQi WANG Jing | 2011 | Chinese Science Bulletin2011，56，9： | 7 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | Editor’s note显示文摘In recent years, driven by ever-increasing market demand in computing, communication, and multimedia applications, the microelectronics industry has undergone rapid development. Because of technical innovation and advances in almost all aspects of materials, processes, equipment, devices, circuits and systems, siliconbased logic and memory IC technologies using nano-scaling continue to be the industry's major R&D focus. This maintains microelectronics industry adherence to the traditional 'Moore's Law', increasing the | HUANG Ru, Guest Editor Peking University Beijing 100871, China ZHAO Bin, Guest Editor Fairchild Semiconductor 32 Discovery, Irvine, CA 92618, USA WANG RunSheng, Guest Editor Assistant CAI YiMao, Guest Editor Assistant Peking University Beijing 100871, China | 2011 | Science China(Information Sciences)2011，54，5： | 3 |
| 4 | CircuitNet:an open-source dataset for machine learning applications in electronic design automation(EDA)显示文摘The electronic design automation(EDA)community has been actively exploring machine learning(ML)for very large-scale integrated computer-aided design(VLSI CAD).Many studies explored learning-based techniques for cross-stage prediction tasks in the design flow to achieve faster design convergence.Although building ML models usually requires a large amount of data. | Zhuomin CHAI Yuxiang ZHAO Yibo LIN Wei LIU Runsheng WANG Ru HUANG | 2022 | Science China(Information Sciences)2022，65，12： | 2 |
| 5 | AlphaFold2 and its applications in the fields of biology and medicine显示文摘AlphaFold2(AF2)is an artificial intelligence(AI)system developed by DeepMind that can predict three-dimensional(3D)structures of proteins from amino acid sequences with atomic-level accuracy.Protein structure prediction is one of the most challenging problems in computational biology and chemistry,and has puzzled scientists for 50 years.The advent of AF2 presents an unprecedented progress in protein structure prediction and has attracted much attention.Subsequent release of structures of more than 200 million proteins predicted by AF2 further aroused great enthusiasm in the science community,especially in the fields of biology and medicine.AF2 is thought to have a significant impact on structural biology and research areas that need protein structure information,such as drug discovery,protein design,prediction of protein function,et al.Though the time is not long since AF2 was developed,there are already quite a few application studies of AF2 in the fields of biology and medicine,with many of them having preliminarily proved the potential of AF2.To better understand AF2 and promote its applications,we will in this article summarize the principle and system architecture of AF2 as well as the recipe of its success,and particularly focus on reviewing its applications in the fields of biology and medicine.Limitations of current AF2 prediction will also be discussed. | Zhenyu Yang Xiaoxi Zeng Yi Zhao Runsheng Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 6 | Microvesicle‐Shuttled miR‐130b Reduces Fat Deposition in Recipient Primary Cultured Porcine Adipocytes by Inhibiting PPAR‐γ Expression显示文摘 | Shifeng Pan Xiaojing Yang Yimin Jia Runsheng Li Ruqian Zhao | 2014 | J. Cell. Physiol2014，，： | 1 |
| 7 | CloudLCA: finding the lowest common ancestor in metagenome analysis using cloud computing显示文摘Estimating taxonomic content constitutes a key problem in metagenomic sequencing data analysis.However,extracting such content from high-throughput data of next-generation sequencing is very time-consuming with the currently available software.Here,we present CloudLCA,a parallel LCA algorithm that significantly improves the efficiency of determining taxonomic composition in metagenomic data analysis.Results show that CloudLCA(1)has a running time nearly linear with the increase of dataset magnitude,(2)displays linear speedup as the number of processors grows,especially for large datasets,and(3)reaches a speed of nearly 215 million reads each minute on a cluster with ten thin nodes.In comparison with MEGAN,a well-known metagenome analyzer,the speed of CloudLCA is up to 5 more times faster,and its peak memory usage is approximately 18.5%that of MEGAN,running on a fat node.CloudLCA can be run on one multiprocessor node or a cluster.It is expected to be part of MEGAN to accelerate analyzing reads,with the same output generated as MEGAN,which can be import into MEGAN in a direct way to finish the following analysis.Moreover,CloudLCA is a universal solution for finding the lowest common ancestor,and it can be applied in other fields requiring an LCA algorithm. | Guoguang Zhao Dechao Bu Changning Liu Jing Li Jian Yang Zhiyong Liu Yi Zhao Runsheng Chen | 2012 | Protein & Cell2012，3，2： | 1 |
| 8 | 基底前脑生长激素抑制素神经元促进高热量食物摄取显示文摘文章简介近年来,人们逐渐发现基底前脑在进食行为中起到一定的调控作用。研究表明,往基底前脑子区域腹侧苍白球注射GABAA受体拮抗剂bicuculine能够极大的增强大鼠对脂肪的选择性。但是具体是哪种类型的神经元负责这一行为尚不清楚。 | Chen Zhu Yun Yao Yan Xiong Mingxiu Cheng Jing Chen Rui Zhao Fangzhou Liao Runsheng Shi 宋森 | 2018 | 科学新闻2018，0，4： | 0 |
| 9 | Xiaoyaosan decoction regulates food intake and body weight via the leptin-leptin receptor-proopiomelanocortin pathway in rats with chronic immobilization stress显示文摘OBJECTIVE: To evaluate the effects of the Xiaoyaosan(XYS) decoction on the food intake and body weight of rats with chronic immobilization stress(CIS), as well as the concentration of serum leptin and the expression of feeding-related neuropeptides [leptin receptor(Ob-R), proopiomelanocortin(POMC), and α-melanocyte-stimulating hormone(α-MSH)] in the hypothalamic arcuate nucleus(ARC).METHODS: We subjected rats to CIS for 3 h a day.The rats were randomly divided into the following groups: control group, 7-day stress group, 21-day stress group and XYS-treated group. The rats in the two stress groups were exposed to CIS for 7 or 21 d.The rats in the XYS-treated group were also exposed to CIS for 21 d and were intragastrically administered the XYS decoction before stress. The body weight and food intake of the rats were measured every day. The content of leptin in serum andα-MSH in the ARC were detected by ELISA, and the expression of neuropeptides in the ARC was assayed by immunofluorescence, Western blot and q RT-PCR.RESULTS: The food intake and body weight of rats exposed to CIS were lower than those of control rats. The serum leptin, and expression levels of ObR, POMC and α-MSH in the ARC were significantly higher than those in the control rats. Treatment with the XYS decoction improved the appetite and the body weight, and down-regulated serum leptin and Ob-R, POMC and α-MSH in hypothalamus ARC.CONCLUSION: The leptin-Ob-R-POMC pathway might be the part of the mechanism underlying XYS's improvement of somatic symptoms such as reduction in food intake and body weight related to CIS. | Wang Xia Fang Chaoyi Wu Jiaxin Wang Shaoxian Zhao Runsheng Ma Jinsheng | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 0 |
| 10 | Genome-wide identification of cancer-related polyadenylated and non-polyadenylated RNAs in human breast and lung cell lines显示文摘Eukaryotic mRNAs consist of two forms of transcripts:poly(A)+ and poly(A),based on the presence or absence of poly(A) tails at the 3 end.Poly(A)+ mRNAs are mainly protein coding mRNAs,whereas the functions of poly(A) mRNA are largely unknown.Previous studies have shown that a significant proportion of gene transcripts are poly(A) or bimorphic(containing both poly(A)+ and poly(A) transcripts).We compared the expression levels of poly(A) and poly(A)+ RNA mRNAs in normal and cancer cell lines.We also investigated the potential functions of these RNA transcripts using an integrative workflow to explore poly(A)+ and poly(A) transcriptome sequences between a normal human mammary gland cell line(HMEC) and a breast cancer cell line(MCF-7),as well as between a normal human lung cell line(NHLF) and a lung cancer cell line(A549).The data showed that normal and cancer cell lines differentially express these two forms of mRNA.Gene ontology(GO) annotation analyses hinted at the functions of these two groups of transcripts and grouped the differentially expressed genes according to the form of their transcript.The data showed that cell cycle-,apoptosis-,and cell death-related functions corresponded to most of the differentially expressed genes in these two forms of transcripts,which were also associated with the cancers.Furthermore,translational elongation and translation functions were also found for the poly(A) protein-coding genes in cancer cell lines.We demonstrate that poly(A) transcripts play an important role in cancer development. | ZHAO GuoGuang JIAO Fei LIAO Qi LUO HaiTao LI Hui SUN Liang BU DeChao YU KunTao ZHAO Yi CHEN RunSheng | 2013 | Science China(Life Sciences)2013，56，6： | 0 |
| 11 | HREELS study on coadsorption of oxygen and cyclohexanone on the Pt(111) surface显示文摘The coadsorption of cyclohexanone and oxygen on Pt(111) has been investigated by HREELS and TDS. At 205 K the presence of oxygen induces an 'extra' red\|shift of the C--O stretching of coadsorbed cyclohexanone. Heating this coadsorbed surface from 205 to 250 K leads to further dehydrogenation to form intermediate species and to complete disappearance of the C--O stretching band. Above 300 K, the molecule rings of dehydrogenation species cleave to form hydrocarbon fragments and CO molecules which directly desorb into the vacuum or react with preadsorbed oxygen to produce CO\-2 which leave the surface immediately. TDS results provide further evidence that the preadsorbed oxygen promotes the decomposition of cyclohexanone. | Yingsheng Wang Xuming Wei Suzhen Ren Runsheng Zhai Yukun Zhao Xianfeng Wang Suxian Zhuang | 1998 | Chinese Science Bulletin1998，43，15： | 0 |
| 12 | Ore-controlling Regularitiesof Structureinthe Lehong Lead-zinc Deposit, Northeastern Yunnan显示文摘1 Introduction The Lehonglead-zincdeposit is a large-sized Pb-Zn depositnewly found in recent years in the Sichuan-Yunnan-Guizhou Lead-zinc Poly-metallic Mineralization Area,which occurrenceis | CUI Junhao HAN Runsheng ZHAO Dong ZHANG Xiaopei | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
| 13 | TGF-βchanges cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy显示文摘Dear Editor,Pulmonary fibrosis(PF)is characterized by failed alveolar reepithelialization and fibroblast activation.1 A continuing struggle in the field has been how to diagnose and treat the disease early and effectively on the basis of shared pathogenetic mechanisms.Transforming growth factor-β(TGF-β)signaling and mitochondria are involved in PF pathogenesis.2 Mitochondrial respiratory chain complexes(RCCs)I,III,IV,and V comprise both nuclear DNA(nDNA)-and mitochondrial DNA(mtDNA)-encoded subunits,and their biogenesis depends on the cooperation of cytoplasmic(cyto)and mitochondrial(mito)translation(Supplementary Fig.1).3 To date,a correlation between PF and RCC biogenesis has not been reported. | Na Zhang Zunling Zhao Yin Zhao Lei Yang Yanhong Xue Yun Feng Jianjun Luo Runsheng Chen Wei Wei Yan Qin | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 14 | Changes in neuropeptides related to food intake in the rat arcuate nucleus after chronic immobilization stress and the effect of comfortable music exposure显示文摘Stress is an inevitable interference factor that seriously affects health.Listening to music is an economical,noninvasive,and highly accepted tool for easing stress.However,physiological studies investigating the ability of music to reduce stress in daily life are limited.We established rat models of chronic immobilization stress(CIS)to observe changes in the hypothalamic arcuate nucleus(ARC)neurons involved in the regulation of food intake and the effect of comfortable classical music exposure.Twenty-one days of stress resulted in decreased food intake and delayed body weight gain,up-regulation of leptin receptor(Ob-R),cocaine-and amphetamine-regulated transcript(CART),proopiomelanocortin(POMC),and alpha-melanocyte-stimulating hormone(α-MSH)expression,and downregulation of neuropeptide Y(NPY)and agouti-related protein(AgRP)expression in the ARC.Thus,peripheral leptin entered the ARC under chronic stress conditions,bound to Ob-R,and affected downstream nerve pathways related to appetite,such as the NPY/AgRP and CART/POMC pathways.Gentle classical music played at 65 dB reversed the abnormal expression of Ob-R and NPY induced by chronic stress.Thus,listening to comfortable music improves changes in ARC neurons related to the regulation of food intake in CIS rats,and these results provide a reference for basic research regarding how music therapy alleviates stress and stress-related health issues. | HAO WANG FANG FANG CHAOYI FANG RUNSHENG ZHAO SHAOXIAN WANG | 2020 | BIOCELL2020，44，3： | 0 |
| 15 | Quantitative Analysis of Mineralization-Alteration Index about the Huize Lead-zinc district in Northeast Yunnan, China显示文摘1 Introduction The super-large Huize lead-zinc ore district is one of the most representative lead-zinc deposits in Northeastern Yunnan poly-metallic deposit concentration district.So far,studies(Liu and Lin,1999;Han et al.,2007)on the type of deposits like the Huize lead-zinc deposit,focused on deposit genesis,the sources of metallogenic materials, | ZHANG Xiaopei HAN Runsheng ZHAO Dong QIU Wenlong HE Jiaojiao CUI Junhao | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员