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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 3 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 4 | Mammalian Telomeres End in a Large Duplex Loop显示文摘 | Jack D Griffith Laurey Comeau Soraya Rosenfield Rachel M Stansel Alessandro Bianchi Heidi Moss Titia de Lange | 1999 | Cell1999，，4： | 1 |
| 5 | Using the Information Decoupling Point to Improve Supply Chain Performance显示文摘 | Rachel M J Towill D R | 1999 | International Journal of Logistics Management1999，10，2： | 1 |
| 6 | A review of photo detectors for sensing light-emitting reporters in biological systems 显示文摘 | Yotter Rachel A Wilson D M | 2003 | IEEE Sensors Journal2003，3，3： | 1 |
| 7 | Time Compression in the supply chain:Information Management is the vital Ingredient显示文摘 | Rachel M J Towill D R | 1998 | Logistics Information Management1998，213，11： | 1 |
| 8 | Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study显示文摘 | Williamson Rachel M Price Jackie F Glancy Stephen Perry Elisa Nee Lisa D Hayes Peter C Frier Brian M Van Look Liesbeth A F Johnston Geoffrey I Reynolds Rebecca M Strachan Mark W J | 2011 | Diabetes Care2011，，5： | 1 |
| 9 | Use of Traceback Methods To Confirm the Source of a Multistate Escherichia coli O157:H7 Outbreak Due to In-Shell Hazelnuts显示文摘 | Miller Benjamin D Rigdon Carrie E Ball Jill Rounds Joshua M Klos Rachel F Brennan Brenda M Arends Katherine D Kennelly Patrick Hedberg Craig Smith Kirk E | 2012 | EN2012，，2： | 1 |
| 10 | Recent progress ingraphene-related nanotechnologies 显示文摘 | Rachel M F Daniel T D Richard P S | 2009 | Recent Patents on Nanotechnology2009，3，3： | 1 |
| 11 | Depression Predicts Self-reported Sleep Quality in Patients With Obstructive Sleep Apnea显示文摘 | Rachel D Wells Ryan C Day Robert M Carry | 2004 | Psychosomotic Medicine2004，66，： | 1 |
| 12 | Typha x glauca dominance and extended hydroperiod constrain restoration of wetland diversity显示文摘 | Aaron M Boers Rachel L D Veltman Zedler J B | 2007 | Ecological Engineering2007，29，： | 1 |
| 13 | Atrial septal defects显示文摘 | Tal Geva Jose D Martins Rachel M Wald | 2014 | The Lancet . 2014 (9932)2014，，9932： | 1 |
| 14 | Electrochemical deposition of copper ( I ) Corrosion Science oxide films 显示文摘 | T D Gloden M G Shmsky Y Z Rachel | 1996 | Chemical Material1996，，8： | 1 |
| 15 | Food sources and intakes of caffeine in the diets of persons in the United States显示文摘 | CAROL D FRARY M S RACHEL K | | 0，，01： | 1 |
| 16 | The role of retinoic acid in the commitment to meiosis显示文摘Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells.This review focuses on the role of retinoic acid(RA)in meiosis,as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and completion.Here,we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8(STRA8)and MEIOSIN,which are responsive to RA and are critical for meiosis.We assert that transcriptional regulation in the spermatogonia is critical for successful meiosis. | Rachel L Gewiss M Christine Schleif Michael D Griswold | 2021 | Asian Journal of Andrology2021，23，6： | 1 |
| 17 | Rotes of theLHX3 andLHX4 LIM homeodomain factors in pituitary develop- ment 显示文摘 | Rachel D M Stephanie C C Chad S H | 2007 | Molecular and Cellular Endocrinology2007，26，5266： | 1 |
| 18 | Multistate Outbreak of Fungal Infection Associated with Injection of Methylprednisolone Acetate Solution from a Single Compounding Pharmacy - United States, 2012显示文摘 | Kainer Marion Wiese Andrew D Benedict Kaitlin Braden Chris Brandt Mary Harris Julie Park Benjamin J Guh Alice Jernigan John Schaefer Melissa Weber J Todd Wise Matt Smith Rachel M Nguyen Duc | 2012 | EN2012，，41： | 1 |
| 19 | N - cadherin loss in POMC - express- ing cells leads to pituitary disorganization 显示文摘 | Ashley D Himes Rachel M | 2011 | Mol Endocrinol2011，25，3： | 1 |
| 20 | Total cycle time compression and the agile supply chain 显示文摘 | Rachel M J Towill D R | 1999 | Interntional Journal of Production Economies1999，62，12： | 1 |
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