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| 1 | Advances in immunotherapy for treatment of lung cancer显示文摘Different approaches for treating lung cancer have been developed over time, including chemotherapy, radiotherapy and targeted therapies against activating mutations. Lately, better understanding of the role of the immunological system in tumor control has opened multiple doors to implement different strategies to enhance immune response against cancer cells. It is known that tumor cells elude immune response by several mechanisms. The development of monoclonal antibodies against the checkpoint inhibitor programmed cell death protein 1(PD-1) and its ligand(PD-L1), on T cells, has led to high activity in cancer patients with long lasting responses. Nivolumab, an anti PD-1 inhibitor, has been recently approved for the treatment of squamous cell lung cancer patients, given the survival advantage demonstrated in a phase III trial. Pembrolizumab, another anti PD-1 antibody, has received FDA breakthrough therapy designation for treatment of non-small cell lung cancer(NSCLC), supported by data from a phase I trial. Clinical trials with anti PD-1/PD-L1 antibodies in NSCLC have demonstrated very good tolerability and activity, with response rates around 20% and a median duration of response of 18 months. | Jean G.Bustamante Alvarez María González-Cao Niki Karachaliou Mariacarmela Santarpia Santiago Viteri Cristina Teixidó Rafael Rosell | 2015 | Cancer Biology & Medicine2015，12，3： | 22 |
| 2 | Economic, social and environmental impact of land consolidation in Galicia显示文摘 | Rafael Crecente Carlos Alvarez Urbano Fra | 2002 | Land Use Policy2002，，2： | 2 |
| 3 | Economic, social and environmenlal impact of land consohdation in Galicia 显示文摘 | Rafael Crecente Carlos Alvarez Urbano Fra | 2002 | Land Use Policy2002，2002，： | 1 |
| 4 | Nonlinear disturbance decoupling control of a binary distillation column显示文摘 | RAFAEL Castro JAIME Alvarez JOAQUIN Alvarez | 1990 | Automatica1990，26，3： | 1 |
| 5 | Economic social and environmental impact of land consolidation in Galicia显示文摘 | Rafael Crecente Carlos Alvarez | 2002 | Land Use Policy2002，，19： | 1 |
| 6 | Economic, social and environmental impact of land consolidation in Galicia 显示文摘 | Rafael Crecente Carlos Alvarez Urbano Fra | 2002 | Land Use Policy2002，19，2： | 1 |
| 7 | An algebraic approach to lens distortion by line rectification 显示文摘 | Luis Alvarez Luis Gomez J Rafael Sendra | 2009 | J Math Imaging Vis2009，35，1： | 1 |
| 8 | Economic,social and environmental impact of land consolidation in galicia显示文摘 | Rafael Crecente Carlos Alvarez Urbano Fra | 2002 | Land Use Policy2002，，19： | 1 |
| 9 | Relationship of IBA and adventitious rooting in M26 shoots cultured in vitro 显示文摘 | Rafael Alvarez Scott Nissen Ellen G Sutter | 1989 | Plant Growth Regulation1989，8，： | 1 |
| 10 | Economic, social and environment impact of land consolidation in Galicia显示文摘 | RAFAEL CRECENTE CARLOS ALVAREZ URBANe3 FRA | 2002 | Land Use Policy2002，19，： | 1 |
| 11 | Postoperative radiotherapy in resected non-small cell lung cancer:The never-ending story显示文摘This manuscript collects in a joint and orderly manner the existing evidence at the present time about postoperative treatment with radiotherapy in non-small cell lung cancer.It also systematically reviews the current evidence,the international recommendations in the most relevant guidelines,the most controversial aspects in clinical and pathological staging,the specific technical aspects of radiotherapy treatment,and also collects all the potential risk factors that have been postulated as significant in the prognosis of these patients,evaluating the possibility of segmenting a particularly sensitive subpopulation with a high risk of relapse on which an adjuvant treatment with radiotherapy could have an impact on their clinical evolution.Finally,currently active trials that aspire to provide more evidence on this topic are reviewed. | Javier Serrano Patricia Calvo Crespo Begoña Taboada Ana Alvarez Gonzalez Rafael Garcia García Antonio Gomez Caamaño Juan Carlos Trujillo Reyes Xabier Mielgo-Rubio Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，10： | 1 |
| 12 | COPI Recruitment Is Modulated by a Rablb- dependent Mechanism显示文摘 | Cecilia Alvarez Rafael Garcia-Mata Elizabeth Brandon | 2003 | Mol Biol Cell2003，14，5： | 1 |
| 13 | Economic, social and environmental impact of land consolidation in Galicia显示文摘 | Rafael Crecente Carlos Alvarez Urbano Fra | 2002 | Land Use Policy2002，，19： | 1 |
| 14 | Economic,social and environmental impact of land consolidation in Galicia显示文摘 | Rafael Crecente Carlos Alvarez Urbano Fra | 2002 | Land Use Policy2002，，19： | 1 |
| 15 | A pharmacological study of Cecropia obtusifolia Bertol aqueous extract显示文摘 | Concepción Pérez-Guerrero Mar??a Dolores Herrera Rafael Ortiz Mar??a Alvarez de Sotomayor Mar??a Angeles Fernández | 2001 | Journal of Ethnopharmacology2001，，3： | 1 |
| 16 | Analysis and design of a secure key exchange scheme 显示文摘 | Rafael alvarez Leandro Tortosa Jose - Fco Vicent | 2009 | Information Sciences2009，，179： | 1 |
| 17 | Randomized Controlled Trial of Aspiration Needle versus Automated Biopsy Device for Transjugular Liver Biopsy显示文摘 | Rafael Ba?ares Sonia Alonso María-Vega Catalina Marta Casado Diego Rincón Magdalena Salcedo Emilio Alvarez Carmen Guerrero Antonio Echenagusía Fernando Camú?ez Gonzalo Simó | 2001 | Journal of Vascular and Interventional Radiology2001，，5： | 1 |
| 18 | Economic,social and environmental impact of land consolidation in Galicia显示文摘 | Rafael Crecente Carlos Alvarez Urbano Fra | | 0，，02： | 1 |
| 19 | Liver transplantation from Maastricht category 2 non-heart-beating donors显示文摘 | Alejandra Otero Manuel Gómez-Gutiérrez Francisco Suárez Francisco Arnal Antón Fernández-García Javier Aguirrezabalaga José García-Buitrón Joaquín Alvarez Rafael Má?ez | 2003 | Transplantation2003，，7： | 1 |
| 20 | Ventilator asso ciated pneumonia is an important risk factor for mortality after major cardiac surgery显示文摘 | Tamayo E Alvarez FJ Martinez Rafael B | 2012 | J Crit Care2012，27，1： | 1 |
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