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33篇 您的检索式：作者名="Rakesh L"

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	题名	作者	年代	出处	被引量
1	Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers.	Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer	2015	World Journal of Stem Cells2015，7，2：	5
2	Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘	Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A	2012	The Lancet . 2012 (9859)2012，，9859：	2
3	Evidence for the benefit of adding a carbon interphase in an all-carbon composite显示文摘	Hariom Dwivedi Rakesh B Mathur Tersem L Dhami	2006	Carbon2006，44，：	1
4	The novel poly (A) polymerase Star-PAP is a signal-regulated switch at the 3 end of mRNAs显示文摘	Li W Rakesh S L Anderson R A	2013	Advances in Bio- logical Regulation2013，53，：	1
5	Immune dysfunction despite high levels of immunoregulatory cytokine gene expression in autologous peripheral blood stem cell transplanted non-Hodgkin's lymphoma patients 显示文摘	Rakesh K Singh A Michelle L	2000	Experimental Hematology2000，28，5：	1
6	The poly A polymerase Star-PAP controls 3 end cleavage by promoting CPSF interaction and specificity toward the pre-mR- NA显示文摘	Rakesh S L Richard A A	2010	The EMBO Journal2010，29，：	1
7	Effects of ref- erence displacement and damage accumulation in wood shear walls 显示文摘	JEFFREY G L RAKESH G THOMAS H M	2004	ASCE Journal of Structural Engineering2004，，130：	1
8	General physical characteristics of dahurian larch (Larix dahurica)from the Russian far east 显示文摘	Rakesh Gupta Robert L Ethington	1996	Forest Products Journal1996，46，4：	1
9	Focal nodular hyperplasia of the liver:a se- quda of tumor therapy 显示文摘	Benny L Joyner Jr Rakesh K	2005	Pediatr Radiol2005，35，：	1
10	Factors determining the outcome of children hospitalized with severe pneumonia 显示文摘	Karalanglin T Rakesh L Ravindra MP	2009	BMC Pediatrics2009，9，：	1
11	Focal nodular hyperplasia of the liver:a sequela of tumor therapy显示文摘	Benny L Joyner Jr Rakesh K	2005	Pediatr Radiol2005，35，12：	1
12	Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination显示文摘	Nam L Rakesh N James YT	2005	Neurosci2005，102，7：	1
13	Calcium addition at the hubbard brook experimental forest increases the capacity forstress tolerance and carbon capture in red spruce trees during the cold season显示文摘	PAUL G S RAKESH M STEPHANIE L	2011	Trees2011，25，6：	1
14	New pressure drop correlation for sieve tray distillation columns显示文摘	Bennett D L Rakesh A Cook P J	1983	AIChE Journal1983，29，3：	1
15	Redox potential in acetone-butanol fermentations显示文摘	Kim J Rakesh B Eugene L I	1988	Applied and Biochemistry Biotechnology1988，18，1：	1
16	Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease显示文摘	Aidan PB Rakesh S Marjolein L	2002	Circulation2002，106，4：	1
17	Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease显示文摘	Aidan PB Rakesh S Marjolein L	2002	Circulation2002，106，4：	1
18	Implementation of grasp in flow shop scheduling显示文摘	Prabhaharan G Khan B S H Rakesh L	2006	The International Journal of Advanced Manufacturing Technology2006，30，11：	1
19	Total phenolics content and antioxidant capacities of microeneapsulated blueberry anthocyanins during in vitro digestion 显示文摘	Floirendo P F Rakesh K S William L K	2014	Food Chemistry2014，153，：	1
20	Redox potential in acetone-butanol fermentations显示文摘	Kim O Rakesh B Eugene L I		0，，01：	1

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