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| 1 | Metabolic syndrome and risk of subsequent colorectal cancer显示文摘The metabolic syndrome and visceral obesity have anincreasing prevalence and incidence in the generalpopulation. The actual prevalence of the metabolicsyndrome is 24% in US population and between24.6% and 30.9% in Europe. As demonstrated by many clinical trials (NAHANES , INTERHART) the metabolic syndrome is associated with an increased risk of both diabetes and cardiovascular disease. In addition to cardiovascular disease, individual components of the metabolic syndrome have been linked to the development of cancer, particularly to colorectal cancer. Colorectal cancer is an important public health problem; in the year 2000 there was an estimated total of 944 717 incident cases of colorectal cancer diagnosed world-wide. This association is sustained by many epidemiological studies. Recent reports suggest that individuals with metabolic syndrome have a higher risk of colon or rectal cancer. Moreover, the clusters of metabolic syndrome components increase the risk of associated cancer. The physiopathological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. Population and experimental studies demonstrated that hyperinsulinemia, elevated C-peptide, elevated body mass index, high levels of insulin growth factor-1, low levels of insulin growth factor binding protein-3, high leptin levels and low adiponectin levels are all involved in carcinogenesis. Understanding the pathological mechanism that links metabolic syndrome and its components to carcinogenesis has a major clinical signifi cance and may have profound health benefi ts on a number of diseases including cancer, which represents a major cause of mortality and morbidity in our societies. | Raluca Pais Horatiu Silaghi Alina Cristina Silaghi Mihai Lucian Rusu Dan Lucian Dumitrascu | 2009 | World Journal of Gastroenterology2009，15，41： | 16 |
| 2 | Autophagy in colorectal cancer:An important switch from physiology to pathology显示文摘Colorectal cancer(CRC) remains a leading cause of cancer death in both men and women worldwide.Among the factors and mechanisms that are involved in the multifactorial etiology of CRC,autophagy is an important transformational switch that occurs when a cell shifts from normal to malignant.In recent years,multiple hypotheses have been considered regarding the autophagy mechanisms that are involved in cancer.The currently accepted hypothesis is that autophagy has dual and contradictory roles in carcinogenesis,but the precise mechanisms leading to autophagy in cancer are not yet fully defined and seem to be context dependent.Autophagy is a surveillance mechanism used by normal cells that protects them from the transformation to malignancy by removing damaged organelles and aggregated proteins and by reducing reactive oxygen species,mitochondrial abnormalities and DNA damage.However,autophagy also supports tumor formation by promoting access to nutrients that are critical to the metabolism and growth of tumor cells and by inhibiting cellular death and increasing drug resistance.Autophagy studies in CRC have focused on several molecules,mainly microtubule-associated protein 1 light chain 3,beclin 1,and autophagy related 5,with conflicting results.Beneficial effects were observed for some agents that modulate autophagy in CRC either alone or,more often,in combination with other agents.More extensive studies are needed in the future to clarify the roles of autophagy-related genes and modulators in colorectal carcinogenesis,and to develop potential beneficial agents for the prognosis and treatment of CRC. | Florin Burada Elena Raluca Nicoli Marius Eugen Ciurea Daniel Constantin Uscatu Mihai Ioana Dan Ionut Gheonea | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 15 |
| 3 | San copolymer membranes with ion exchangers for Cu(Ⅱ)removal from synthetic wastewater by electrodialysis显示文摘Heterogeneous membranes were obtained by using styrene-acrylonitrile copolymer(SAN)blends with low content of ion-exchanger particles(5 wt.%). The membranes obtained by phase inversion were used for the removal of copper ions from synthetic wastewater solutions by electrodialytic separation. The electrodialysis was conducted in a three cell unit, without electrolyte recirculation. The process, under potentiostatic or galvanostatic control, was followed by p H and conductivity measurements in the solution. The electrodialytic performance,evaluated in terms of extraction removal degree(rd) of copper ions, was better under potentiostatic control then by the galvanostatic one and the highest(over 70%) was attained at8 V. The membrane efficiency at small ion-exchanger load was explained by the migration of resin particles toward the pores surface during the phase inversion. The prepared membranes were characterized by various techniques i.e. optical microscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis and differential thermal analysis and contact angle measurements. | Simona Caprarescu Mihai Cosmin Corobea Violeta Purcar Catalin Ilie Spataru Raluca Ianchis Gabriel Vasilievici Zina Vuluga | 2015 | Journal of Environmental Sciences2015，27，9： | 8 |
| 4 | Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology显示文摘Virtually all drug interventions that have been successful pre-clinically in experimental stroke have failed to prove their efficacy in a clinical setting. This could be partly explained by the complexity and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efficacious in clinical practice. One aspect of crucial importance in the physiopathology of stroke which is not completely understood is neuroinflammation. At the present time, it is becoming evident that subtle, but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity, hypertension, diabetes and atherosclerosis could act as 'silent contributors' promoting a chronic proinflammatory state. This could aggravate the outcome of various pathological entities and can contribute to a number of subsequent post-stroke complications such as dementia, depression and neurodegeneration creating a pathological vicious cycle. Moreover, recent data suggests that the inflammatory process might be closely linked with multiple neurodegenerative pathways related to depression. In addition, pro-inflammatory cytokines could play a central role in the pathophysiology of both depression and dementia. | Raluca Elena Sandu Ana Maria Buga Adriana Uzoni Eugen Bogdan Petcu Aurel Popa-Wagner | 2015 | Neural Regeneration Research2015，10，9： | 6 |
| 5 | 煽动性的肠疾病苛评的内视镜的管理显示文摘 Stricture formation is a common complication of Crohn’s disease, occurring in approximately one third of all patients with this condition. While the traditional management of such strictures has been largely surgical, there have been case series going back three decades high-lighting the potential role of endoscopic balloon dilation in this clinical setting. This review article summarizes the stricture pathogenesis, focusing on known clinical and genetic risk factors. It then highlights the endo-scopic balloon dilation research to date, with particular emphasis on three large recent case series. It concludes by describing the literature consensus regarding specific methodology and presenting avenues for future investigations. | Raluca Vrabie Gerald L Irwin David Friedel | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，11： | 5 |
| 6 | 100 GHz silicon–organic hybrid modulator显示文摘Electro-optic modulation at frequencies of 100 GHz and beyond is important for photonic-electronic signal processing at the highest speeds.To date,however,only a small number of devices exist that can operate up to this frequency.In this study,we demonstrate that this frequency range can be addressed by nanophotonic,silicon-based modulators.We exploit the ultrafast Pockels effect by using the silicon–organic hybrid(SOH)platform,which combines highly nonlinear organic molecules with silicon waveguides.Until now,the bandwidth of these devices was limited by the losses of the radiofrequency(RF)signal and the RC(resistor-capacitor)time constant of the silicon structure.The RF losses are overcome by using a device as short as 500 μm,and the RC time constant is decreased by using a highly conductive electron accumulation layer and an improved gate insulator.Using this method,we demonstrate for the first time an integrated silicon modulator with a 3dB bandwidth at an operating frequency beyond 100 GHz.Our results clearly indicate that the RC time constant is not a fundamental speed limitation of SOH devices at these frequencies.Our device has a voltage–length product of only V_(π)L=11 V mm,which compares favorably with the best silicon-photonic modulators available today.Using cladding materials with stronger nonlinearities,the voltage–length product is expected to improve by more than an order of magnitude. | Luca Alloatti Robert Palmer Sebastian Diebold Kai Philipp Pahl Baoquan Chen Raluca Dinu Maryse Fournier Jean-Marc Fedeli Thomas Zwick Wolfgang Freude Christian Koos Juerg Leuthold | 2014 | Light(Science & Applications)2014，3，1： | 3 |
| 7 | From NAFLD in clinical practice to answers from guidelines显示文摘 | Fabio Nascimbeni Raluca Pais Stefano Bellentani Christopher Paul Day Vlad Ratziu Paola Loria Amedeo Lonardo | 2013 | Journal of Hepatology2013，，： | 3 |
| 8 | A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver显示文摘 | Raluca Pais Fréderic Charlotte Larissa Fedchuk Pierre Bedossa Pascal Lebray Thierry Poynard Vlad Ratziu | 2013 | Journal of Hepatology2013，，： | 2 |
| 9 | Liver fibrosis evaluation using real-time shear wave elastography: Applicability and diagnostic performance using methods without a gold standard显示文摘 | Thierry Poynard Mona Munteanu Elena Luckina Hugo Perazzo Yen Ngo Luca Royer Larysa Fedchuk Florence Sattonnet Raluca Pais Pascal Lebray Marika Rudler Dominique Thabut Vlad Ratziu | 2013 | Journal of Hepatology2013，，5： | 2 |
| 10 | A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver<!-- Doctopic: GMD -->显示文摘 | Raluca Pais Fréderic Charlotte Larissa Fedchuk Pierre Bedossa Pascal Lebray Thierry Poynard Vlad Ratziu | 2013 | Journal of Hepatology2013，，： | 2 |
| 11 | Congenital Heart Disease in the General Population: Changing Prevalence and Age Distribution显示文摘 | Ariane J. Marelli Andrew S. Mackie Raluca Ionescu-Ittu Elham Rahme Louise Pilote | 2007 | Circulation2007，，2： | 2 |
| 12 | The stabilization of Au NP-AChE nanocomposites by biosilica encapsulation for the development of a thiocholine biosensor 显示文摘 | Raluca B Nikos A C | 2012 | Bioelectrochemistry2012，86，： | 1 |
| 13 | Product Placement in Romanian Movies Produced After 1989 显示文摘 | CristJna Raluca Delia | 2010 | Journal of Media Re- search2010，，8： | 1 |
| 14 | Semiflexible star-shaped mesogens as nonconventional columnar liquid crystals显示文摘 | Matthias Lehmann Raluca I Gearba Michel H J Koch | 2004 | Chem Mater2004，16，3： | 1 |
| 15 | Tailoring the themotropic behavior of tetra Substituted phthalocyanines via the lateral chains architecture显示文摘 | RALUCA G ALEXANDER I B BART G | 2005 | Chem Mater2005，17，： | 1 |
| 16 | Immunohistochemical evalu- ation of COX- 2 expression in HPV -positive cervical squa- mous intraepithelial lesions显示文摘 | Raluca B Cornelia A Simona E | 2011 | Rom J Morphol Embryol2011，52，1： | 1 |
| 17 | CD105/Ki67 double immunnos- raining expression in liver metastasis from colon carcinoma显示文摘 | Raluca A Anca M Pusa G | 2011 | Rom J Morphol Embryo12011，52，2： | 1 |
| 18 | Tailoring the thermotropic behavior of tetra-substituted phthalocyanines via the lateral chains architecture 显示文摘 | RALUCA G ALEXANDER I B BART G | 2005 | Chem Mater2005，17，： | 1 |
| 19 | Informative priors based on transcription factor structural class improve de novo motif discovery 显示文摘 | Leelavati Narlikar Raluca Gorda Uwe Ohler Alexander J Hartemink | 2006 | Bioinformatics2006，22，14： | 1 |
| 20 | Tailoring thethemotropic behavior of tetra substituted phthal-ocyaninesvia the lateral chains architecture显示文摘 | Raluca G AlexanderL I B Bart G | 2005 | Chemistry ofMaterials2005，17，11： | 1 |
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