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| 1 | Phenol contents,oxidase activities, and the resistance of co- ffee to the leaf miner Leucoptera coffeell显示文摘 | Ramiro D Guerreiro-Filho O Mazzafera P | 2006 | J Chem Ecol2006，32，： | 1 |
| 2 | Results of laparoscopic cholecystectomy in a third-level university hospital after 17 years of experience显示文摘 | Priego P Ramiro C Molina JM | 2009 | Rev Esp Enferm Dig2009，101，1： | 1 |
| 3 | Relativistic electronic structure of an icosahedral Au12Pd cluster显示文摘 | Ramiro A P Lucia H A | 1999 | Chem Phys Lett1999，303，： | 1 |
| 4 | An easy synthesis of pyranopyrimidines显示文摘 | Herrera A Martinez - Alvarez R Ramiro P | 2006 | Monatshefte fur Chemie2006，137，： | 1 |
| 5 | Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8显示文摘 | Elena Garcí a-Martí n Rosa M Pizarro Carmen Martí nez Yolanda Gutierrez-Martí n Gabriela Pé rez Ramiro Jover José AG Agú ndez | 2006 | Pharmacogenomics2006，，4： | 1 |
| 6 | Soil seed banks in the semi-arid Prepuna of Bolivia显示文摘 | Ramiro P L | 2003 | Plant Ecology2003，168，： | 1 |
| 7 | Phenol Contents, oxidase activities, and the resistance of coffee to the leaf miner Leu- copteracoffeeIla 显示文摘 | Ramiro D A Guerreiro-Filho O Mazzafera P | 2006 | JChemEcol2006，32，： | 1 |
| 8 | A knowledge-based evolutionary strategy for scheduling problems with bottlenecks显示文摘 | Ramiro V Camino R V Jorge P | 2003 | European Journal of Operational Research2003，145，1： | 1 |
| 9 | Detection of Helicobacter pylori resistance to clarithromycin and fluoroquinolones in Brazil:A national survey显示文摘AIM To evaluate bacterial resistance to clarithromycin and fluoroquinolones in Brazil using molecular methods.METHODS The primary antibiotic resistance rates of Helicobacter pylori(H. pylori) were determined from November 2012 to March 2015 in the Southern,South-Eastern,Northern,North-Eastern,and Central-Western regions of Brazil. Four hundred ninety H. pylori patients [66% female,mean age 43 years(range: 18-79)] who had never been previously treated for this infection were enrolled. All patients underwent gastroscopy with antrum and corpus biopsies and molecular testing using Geno Type Helico DR(Hain Life Science,Germany). This test was performed to detect the presence of H. pylori and to identify point mutations in the genes responsible for clarithromycin and fluoroquinolone resistance. The molecular procedure was divided into three steps: DNA extraction from the biopsies,multiplex amplification,and reverse hybridization. RESULTS Clarithromycin resistance was found in 83(16.9%) patients,and fluoroquinolone resistance was found in 66(13.5%) patients. There was no statistical difference in resistance to either clarithromycin or fluoroquinolones(P = 0.55 and P = 0.06,respectively) among the different regions of Brazil. Dual resistance to clarithromycin and fluoroquinolones was found in 4.3%(21/490) of patients. The A2147 G mutation was present in 90.4%(75/83),A2146 G in 16.9%(14/83) and A2146 C in 3.6%(3/83) of clarithromycin-resistant patients. In 10.8%(9/83) of clarithromycin-resistant samples,more than 01 mutation in the 23 S r RNA gene was noticed. In fluoroquinolone-resistant samples,37.9%(25/66) showed mutations not specified by the Geno Type Helico DR test. D91 N mutation was observed in 34.8%(23/66),D91 G in 18.1%(12/66),N87 K in 16.6%(11/66) and D91 Y in 13.6%(9/66) of cases. Among fluoroquinolone-resistant samples,37.9%(25/66) showed mutations not specified by the Geno Type Helico DR test. CONCLUSION The H. pylori clarithromycin resistance rate in Brazil is at the borderline(15%-20%) for applying the standard triple therapy. The fluoroquinolone resistance rate(13.5%) is equally concerning. | Bruno Squarcio Sanches Gustavo Miranda Martins Karine Lima Bianca Cota Luciana Dias Moretzsohn Laercio Tenorio Ribeiro Helenice P Breyer Ismael Maguilnik Aline Bessa Maia Joffre Rezende-Filho Ana Carolina Meira Henrique Pinto Edson Alves Ramiro Mascarenhas Raissa Passos Julia Duarte de Souza Osmar Reni Trindade Luiz Gonzaga Coelho | 2016 | World Journal of Gastroenterology2016，22，33： | 1 |
| 10 | Entamoeba histolytica and/or Entamoeba disport infection frequency in HIV+/AIDS patients in Mexico city显示文摘 | Moran P Ramos F Ramiro M | 2005 | Exp Parasitol2005，110，3： | 1 |
| 11 | Infection by human im- munodefieiency virus-1 is not a risk factor for amebiasis显示文摘 | Moran P Ramos F Ramiro M | 2005 | Am J Trop Med Hyg2005，73，2： | 1 |
| 12 | Cadmium ( Ⅱ )and zinc ( Ⅱ ) adsorption by the aquatic raoss fontinalis antipyretica:effect of temperature, pH and water hardness 显示文摘 | Ramiro J E M Rosana P Rui A R B | 2004 | Water Research2004，38，： | 1 |
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