|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | World Gastroenterology Organisation Global Guidelines: Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis显示文摘 | Douglas R. LaBrecque Zaigham Abbas Frank Anania Peter Ferenci Aamir G. Khan Khean-Lee Goh Saeed S. Hamid Vasily Isakov Maribel Lizarzabal Manuel M. Pe?aranda Juan F.R. Ramos Shiv Sarin Davor Stimac Alan B.R. Thomson Muhammed Umar Justus Krabshuis Anton Le | 2014 | Journal of Clinical Gastroenterology2014，，6： | 3 |
| 3 | Occipital condyle screw placement and occipitocervical instrumentation using three-dimensional image-guided navigation 显示文摘 | Le TV Burkett C Ramos E | 2012 | J Clin Neu- rosci2012，19，5： | 1 |
| 4 | Sequencing ofthe von Hippel - Lindau gene in canine renal carcinoma 显示文摘 | Pressler BM Williams LE Ramos - Vara JA | 2009 | JVet Interm Med2009，23，3： | 1 |
| 5 | Contrasting cardiopulmonary responses to incremental exercise in patients with schistosomiasis-associated and idiopathic pulmonary arterial hypertension with similar resting hemodynamic impairment 显示文摘 | Valois FM Nery LE Ramos RP | 2014 | PloS One2014，9，87： | 1 |
| 6 | Occipital condyle screw placement and occipitocervical instrumentation using three-dimensional image-guided navigation显示文摘 | Le TV Burkett C Ramos E | 2012 | J Clin Neurosci2012，19，5： | 1 |
| 7 | Occipital condyle screw placement and oecipitoeervical instmmentalion using three- dimensional image-guided navigation 显示文摘 | Le TV Burkett C Ramos E | 2012 | J Clin Neurosei2012，19，5： | 1 |
| 8 | Protection from type 1diabtes by vitaminD receptor haplotypes显示文摘 | Ramos LE Jansen T Ivaskevicius V | 2007 | Diabetes Res ClinPract2007，77，1： | 1 |
| 9 | Elevated 'hy- droxyl radical' generation in vivo in an animal model of amyo- trophic lateral sclerosis显示文摘 | Bogdanov MB Ramos LE Xu Zuo-shang | 1998 | Journal of Neurochemistry1998，71，3： | 1 |
| 10 | Oc- cipital condyle screw placement and oc- cipitocer-ical instrumentation using three - dimensional image - guided na-i- gation 显示文摘 | Le TV Burkett C Ramos E | 2012 | J Clin Neurosci2012，19，5： | 1 |
| 11 | Frnctional mediastinal paraghyroid cyst dynamics of parathyroid home one secretion during cyst aspirations and surgery显示文摘 | Ramos gabatin A Mallette LE Bringhurst FR | 1985 | Am J Med1985，79，5： | 1 |
| 12 | Campylobacter jejuni binds intestinal H (O) antigen ( Fucal, 2Galβ1, 4GIcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection显示文摘 | Ruiz-Palacios GM Cervantes LE Ramos P | 2003 | J Biol Chem2003，278，14： | 1 |
| 13 | Zinc environment in aluminoborosilicate glasses by Zn K-edge extended X-ray absorption fine structure spectroseopy显示文摘 | Le GRAND M RAMOS A Y CALAS G | 2000 | Journal of Materials Research Society2000，15，： | 1 |
| 14 | Occipital condyle screw placement and oceipitocervieal instrumentation using three- dimensional image-guided navigation 显示文摘 | Le TV Burkett C Ramos E | 2012 | J Clin Neurosci2012，19，5： | 1 |
| 15 | Antimicrobial activity of edible coatings prepared from whey protein isolate and formu- lated with various antimicrobial agents显示文摘 | Ramos S L Santos A C Le~o M V | 2012 | International Dairy Journal2012，25，2： | 1 |
| 16 | Occipital condyle screwplacement and occipitocervical instrumentation using three-di-mensiona] image-guided navigation显示文摘 | Le TV Burkett C Ramos E | 2012 | J Clin Neurosci2012，19，5： | 1 |
| 17 | Diagnostic evaluation of the fetal face using 3-dimensional ultrasound显示文摘 | Ramos GA Ylagan MV Romine LE | 2008 | Ultrasound Q2008，24，： | 1 |
| 18 | Elevated 'hydroxyl radical' generation in vivo in an animal model of amyotrophic lateral sclerosis 显示文摘 | Bogdanov MB Ramos LE Xu Zuo-shang | 1998 | Journal of Neurochemistry1998，71，3： | 1 |
| 19 | The relationship between alexithymia and perinatal depressive symptomatology 显示文摘 | Le HN Ramos MA Mufioz RF | 2007 | J Psychosom Res2007，62，2： | 1 |
| 20 | Self-reported participation restrictions in normal hearing individuals in thyroid ontogeny: Evidence of subclinical changes显示文摘Purpose: To verify evidence of subclinical alterations through self-reported participation restrictions in normal hearing individuals and congenital hypothyroidism patients.Methods: An analytical, quantitative, cross-sectional exploratory study with a 1:1 ratio, consisting of a convenience sample of 86 normal hearing individuals with(n = 42) and without(n = 44) congenital hypothyroidism diagnosis. All participants underwent tonal and speech audiometry, immitance and distortion product otoacoustic emissions. The researchers excluded people with hearing loss, genetic syndromes and metabolic diseases. The instrument used for evaluate of self-reported participation restrictions was the HHIE-adapted questionnaire, composed of 25 questions, 12 of which were social domain and 13 emotional domain. Student's ttest and chi-square test were used for statistical analysis at a significance level of 5%.Results: There was a significant(p < 0.001) self-reported participation restrictions in CH(61.9%), with a greater relevance for the social domain(p = 0.002). There was a greater frequency of mild/moderate(40.5%)and higher prevalence of association with clinical factors and adherence to treatment.Conclusion: The findings indicate that self-reported participation restrictions in normal hearing individuals with congenital hypothyroidism was more significant than in the non-exposed group, suggesting evidence of subclinical auditory abnormalities in this population. | Caio Le?nidas Oliveira de Andrade Gabriela Carvalho Machado Luan Paulo Franco Magalh?es Elen Pereira de Jesus Elaine Alves Matias Taíse Lima de Oliveira Cerqueira Hélida Braga de Oliveira Luciene da Cruz Fernandes Helton Estrela Ramos Crésio de Arag?o Dantas Alves | 2019 | Journal of Otology2019，14，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员