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| 1 | Control of Grain Size and Weight by the OsMKKK10-OsM KK4-OsMAPK6 Signaling Pathway in Rice显示文摘谷物尺寸是在庄稼决定谷物产量的关键农学的特点之一。然而,在庄稼位于谷物尺寸控制下面的机制留下逃犯。这里,我们证明断然表明小径的 OsMKKK10-OsMKK4-OsMAPK6 在米饭调整谷物尺寸和重量。在米饭,当组成地活跃的 OsMKKK10 (CA-OsMKKK10 ) 的 overexpression 导致大、重的谷物,长圆锥花序,和高植物时, OsMKKK10 功能的损失导致小、轻的谷物,短圆锥花序,和半矮子植物。OsMKKK10 交往与并且 phosphorylates OsMKK4。我们识别了 OsMKK4 gain-of-function 异种(large11-1D )? 那生产大、重的谷物。OsMKK4 large11-1D 等位基因编码的 A227T 比 OsMKK4 举办更强壮的 kinase 活动。植物 overexpressing OsMKK4 (OsMKK4-DD ) 的一种组成地活跃的形式也生产大谷物。进一步生物化学、基因的分析表明 OsMKKK10, OsMKK4,和 OsMAPK6 在一条普通小径工作控制谷物尺寸。一起拿,我们的学习在米饭为谷物尺寸和重量的 OsMKKK10-OsMKK4-OsMAPK6 调停串联的控制建立一个重要基因、分子的框架。 | Ran Xu Penggen Duan Haiyue Yu Zhengkui Zhou Baolan Zhang Ruci Wang Jing Li Guozheng Zhang Shangshang Zhuang Jia Lyu Na Li Tuanyao Chai Zhixi Tian Shanguo Yao Yunhai Li | 2018 | Molecular Plant2018，11，6： | 33 |
| 2 | Parameters of Coseismic Reverse- and Oblique-Slip Surface Ruptures of the 2008 Wenchuan Earthquake,Eastern Tibetan Plateau显示文摘在 2008 年 5 月 12 日, M w 7.9 Wenchuan 地震破裂了同时,, Longmenshan 的中间的片断插入了的 Beichuan, Pengguan 和 Xiaoyudong 差错在西藏的高原的东方边缘系上带子。领域调查抑制与 Wenchuan 地震有关的表面破裂模式,长度和偏移量。Beichuan 差错有趋势 NE 有 240 km 的全部的长度的权利侧面的反向的破裂。重估产出 6.5 ±的最大的垂直偏移量 0.5 m 和 4.9 ±的最大的权利侧面的偏移量为它的北片断的 0.5 m,它最大的偏移量被发现;最大的垂直偏移量是 6.2 ±为它的南部的片断的 0.5 m。Pengguan 差错有趋势 NE 纯反向的破裂与大约 3.5 m 的最大的垂直偏移量长的大约 72 km。Xiaoyudong 差错有在 Beichuan 和 Pengguan 之间长的大约 7 km 指责的 NW 惹人注目的左侧面的反向的破裂,与 3.4 m 的最大的垂直偏移量和 3.5 m 的左侧面的偏移量。多重 co 地震的表面破裂的这个模式在之中最近的大地震和礼品最复杂大得多的危险比如果他们个别地破裂了。破裂长度最长因为反向的指责事件曾经报导了。 | XU Xiwei YU Guihua CHEN Guihua RAN Yongkang LI Chenxia CHEN Yuegau CHANG Chungpai | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 30 |
| 3 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 4 | Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota显示文摘The phenylalanine-tyrosine-dopa-dopamine pathway provides dopamine to the brain.Iin this process,tyrosine hydroxylase(TH)isthe rate-limiting enzyme that hydroxylates tyrosine and generates levodopa(L-dopa)with tetranydrobiopterin(BH_(4))as a coenzyme.Here,we show that oral berberine(BBR)might supply H^(·) through dihydroberberine(reduced BBR produced by bacterial nitroreductase)and promote the production of BHl from dihydrobiopterin;the increased BH,enhances TH activity,which accelerates the production of L-dopa by the gut bacteria.Oral BBR acts in a way similar to vitamins.The L-dopa produced by theintestinal bacteria enters the brain through the circulation and is transformed to dopamine.To verify the gut-brain dialog activatedby BBR's effect,Enterococcus foecalis or Enterococcus faecium was transplanted into Parkinson's disease(PD)mice.The bacteriasignificantly increased brain dopamine and ameliorated PD manifestation in mice;additionally,combination of BBR with bacteriashowed better therapeutic effect than that with bacteria alone.Moreover,2,4,6-trimethy-pyranylium tetrafluoroborate(TMP-TFB)-derivatized matrix-assisted laser desorption mass spectrometry(MALDI-MS)imaging of dopamine identihed elevated striataldopamine levels in mouse brains with oral Enterococcus,and BBR strengthened the imaging intensity of brain dopamine.Theseresults demonstrated that BBR was an agonist of TH in Enterococcus and could lead to the production of L-dopa in the gut.Furthermore,a study of 28 patients with hyperlipidemia conhrmed that oral BBR increased bloodfecal L-dopa by the intestinalbacteria.Hence,BBR might improve the brain function by upregulating the biosynthesis of-dopa in the gut microbiota through avitamin-like effect. | Yan Wang Qian Tong Shu-Rong Ma Zhen-Xiong Zhao Li-Bin Pan Lin Cong Pei Han Ran Peng Hang Yu Yuan Lin Tian-Le Gao Jia-Wen Shou Xiao-Yang Li Xian-Feng Zhang Zheng-Wei Zhang Jie Fu Bao-Ying Wen Jin-Bo Yu Xuetao Cao Jian-Dong Jiang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 5 | Annual 30-m land use/land cover maps of China for 1980–2015 from the integration of AVHRR, MODIS and Landsat data using the BFAST algorithm显示文摘Annual land use land cover(LULC)change information at medium spatial resolution(i.e.at 30 m)is required in numerous subjects,such as biophysical modelling,land management and global change studies.Annual LULC information,however,is usually not available at continental or national scale due to reasons such as insufficient remote sensing data coverage or lack of computational capabilities.Here we integrate high temporal resolution and coarse spatial resolution satellite images(i.e.,Moderate Resolution Imaging Spectroradiometer(MODIS)and Global Inventory Modelling and Mapping Studies(GIMMS)normalized difference vegetation index(NDVI))with high spatial resolution datasets(China’s Land-Use/cover Datasets(CLUDs)derived from 30-meter Landsat TM/ETM+/OLI)to generate reliable annual nominal 30 m LULC maps for the whole of China between 1980 and 2015.We also test the performance of a statistical based change detection algorithm(Breaks for Additive Seasonal and Trend),originally designed for tracking forest change,in classifying all-type LULC change.As a result,a nominal 30 m annual land use/land cover datasets(CLUD-A)from 1980 to 2015 was developed for the whole China.The mapping results were assessed with a change sample dataset,a regional annual validation sample set and a three-year China sample set.Of the detected change years,75.61%matched the exact time of conversion within±1 year.Annual mapping results provided a detail process of urbanization,deforestation,afforestation,water and cropland dynamics over the past 36 years.The consistent characterization of land change dynamics for China can be further used in scientific research and to support land management for policy-makers. | Yidi XU Le YU Dailiang PENG Jiyao ZHAO Yuqi CHENG Xiaoxuan LIU Wei LI Ran MENG Xinliang XU Peng GONG | 2020 | Science China Earth Sciences2020，63，9： | 12 |
| 6 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 7 | Sorafenib extends the survival time of patients with multiple recurrences of hepatocellular carcinoma after liver transplantation显示文摘 | Wei-feng TAN Zhi-quan QIU Yong YU Rong-zheng RAN Bing YI Wan-yee LAU Chen LIU Ying-he QIU Fei-ling FENG Jing-han WANG Pei-ning YAN Bai-he ZHANG Meng-chao WU Xiang-ji LUO Xiao-qing JIANG | 2010 | Acta Pharmacologica Sinica2010，31，12： | 11 |
| 8 | Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury显示文摘The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using overexpression and knockdown constructs. Activation of the Notch signaling pathway by Notch1 or Jagged1 overexpression enhanced the migration, invasiveness and angiogenic ability of endothelial progenitor cells. Suppression of the Notch signaling pathway with Notch1 or Jagged1 si RNAs reduced the migratory capacity, invasiveness and angiogenic ability of endothelial progenitor cells. Activation of the Notch signaling pathway in vivo in a rat model of mild traumatic brain injury promoted neurovascular repair. These findings suggest that the activation of the Notch signaling pathway promotes blood vessel formation and tissue repair after brain trauma. | Qi-shan Ran Yun-hu Yu Xiao-hong Fu Yuan-chao Wen | 2015 | Neural Regeneration Research2015，10，8： | 11 |
| 9 | Mapping the permafrost stability on the Tibetan Plateau for 2005–2015显示文摘Data scarcity is a major obstacle for high-resolution mapping of permafrost on the Tibetan Plateau(TP).This study produces a new permafrost stability distribution map for the 2010 s(2005–2015)derived from the predicted mean annual ground temperature(MAGT)at a depth of zero annual amplitude(10–25 m)by integrating remotely sensed freezing degree-days and thawing degree-days,snow cover days,leaf area index,soil bulk density,high-accuracy soil moisture data,and in situ MAGT measurements from 237 boreholes on the TP by using an ensemble learning method that employs a support vector regression model based on distance-blocked resampled training data with 200 repetitions.Validation of the new permafrost map indicates that it is probably the most accurate of all currently available maps.This map shows that the total area of permafrost on the TP,excluding glaciers and lakes,is approximately 115.02(105.47–129.59)×10^4 km^2.The areas corresponding to the very stable,stable,semi-stable,transitional,and unstable types are 0.86×10^4,9.62×10^4,38.45×10^4,42.29×10^4,and 23.80×10^4 km^2,respectively.This new map is of fundamental importance for engineering planning and design,ecosystem management,and evaluation of the permafrost change in the future on the TP as a baseline. | Youhua RAN Xin LI Guodong CHENG Zhuotong NAN Jinxing CHE Yu SHENG Qingbai WU Huijun JIN Dongliang LUO Zhiguang TANG Xiaobo WU | 2021 | Science China Earth Sciences2021，64，1： | 11 |
| 10 | Classification of Irreducible Weight Modules with a Finite-dimensional Weight Space over Twisted Heisenberg-Virasoro Algebra显示文摘We show that the support of an irreducible weight module over the twisted Heisenberg-Virasoro algebra,which has an infinite-dimensional weight space,coincides with the weight lattice andthat all nontrivial weight spaces of such a module are infinite dimensional.As a corollary,we obtainthat every irreducible weight module over the twisted Heisenberg-Virasoro algebra,having a nontrivialfinite-dimensional weight space,is a Harish-Chandra module(and hence is either an irreducible highestor lowest weight module or an irreducible module from the intermediate series). | Ran SHEN Yu Cai SU | 2007 | Acta Mathematica Sinica,English Series2007，23，1： | 11 |
| 11 | Jasmonic acid carboxyl methyltransferase regulates development and herbivory-induced defense response in rice显示文摘Jasmonic acid(JA) and related metabolites play a key role in plant defense and growth. JA carboxyl methyltransferase(JMT) may be involved in plant defense and development by methylating JA to methyl jasmonate(Me JA) and thus influencing the concentrations of JA and related metabolites. However, no JMT gene has been well characterized in monocotyledon defense and development at the molecular level. After we cloned a rice JMT gene,Os JMT1, whose encoding protein was localized in the cytosol, we found that the recombinant Os JMT1 protein catalyzed JA to Me JA. Os JMT1 is up-regulated in response to infestation with the brown planthopper(BPH; Nilaparvata lugens). Plants in which Os JMT1 had been overexpressed(oeJMT plants) showed reduced height and yield. These oe-JMT plants also exhibited increased Me JA levels but reduced levels of herbivore-induced JA and jasmonoyl-isoleucine(JAIle). The oe-JMT plants were more attractive to BPH female adults but showed increased resistance to BPH nymphs,probably owing to the different responses of BPH female adults and nymphs to the changes in levels of H_2O_2 and Me JA in oe-JMT plants. These results indicate that Os JMT1,by altering levels of JA and related metabolites, plays a role in regulating plant development and herbivore-induced defense responses in rice. | Jinfeng Qi Jiancai Li Xiu Han Ran Li Jianqiang Wu Haixin Yu Lingfei Hu Yutao Xiao Jing Lu Yonggen Lou | 2016 | Journal of Integrative Plant Biology2016，58，6： | 10 |
| 12 | Risk factors of intra-abdominal bacterial infection after liver transplantation in patients with hepatocellular carcinoma显示文摘Objective: To explore the risk factors of intra-abdominal bacterial infection(IAI) after liver transplantation(LT) in patients with hepatocellular carcinoma(HCC). Methods: A series of 82 HCC patients who received LT surgeries in our department between March 2004 and April 2010 was recruited in this study. Then we collected and analyzed the clinical data retrospectively. Statistical analysis system(SPSS) software was adopted to perform statistical analysis. Chi-square test, t-test and Wilcoxon rank sum test were used to analyze the clinical data and compute the significance of the incidences of early-stage IAI after LT for HCC patients. Binary logistic regression was performed to screen out the risk factors, and multiple logistic regression analyses were performed to compute the independent risk factors. Results: A series of 13 patients(13/82, 15.9%) had postoperative IAI. The independent risk factors of postoperative intra-abdominal bacterial infections after LT for HCC patients were preoperative anemia [Hemoglobin(HGB) <90 g/L] and postoperative abdominal hemorrhage(72 hours >400 mL), with the odds ratios at 8.121(95% CI, 1.417 to 46.550, P=0.019) and 5.911(95% CI, 1.112 to 31.432, P=0.037). Conclusions: Postoperative IAI after LT in patients with HCC was a common complication. Preoperative moderate to severe anemia, as well as postoperative intra-abdominal hemorrhage more than 400 mL within the first 72 hours might independently indicate high risk of IAI for these patients. | Kai Nie Rongzheng Ran Weifeng Tan Bin Yi Xiangji Luo Yong Yu Xiaoqing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，3： | 10 |
| 13 | Cognitive impairment and the associated risk factors among the elderly in the Shanghai urban area:a pilot study from China显示文摘Objectives:Our study aimed to investigate the prevalence of cognitive impairment(CI)and the associated risk factors among elderly people in Shanghai urban area,China.Methods:A population-based survey was conducted among people aged 55 years or older in urban areas of Shanghai.Face-to-face interviews were carried out to collect information including demographic characteristics,medical history,and medication use,etc.The validated Chinese version of the Mini-Mental State Examination(MMSE)was used to screen subjects with CI,and the criteria of CI were adjusted for education levels.Results:A total of 3,176 home-living residents(≥55 years old)were included in the study.Among them,266 people(102 men and 164 women)were identified as cognition impaired,with a prevalence of 8.38%(266/3,176,95%CI:(8.26,8.49))for both genders,9.21%(102/1,107,95%CI:(9.18,9.33))for men and 7.93%(164/2,069,95%CI:(7.80,8.09))for women,respectively.Furthermore,we found that several significant risk factors,including social factors(education,number of children,marriage status,and family structure),physiological factors(age,blood glucose level,and obesity),factors on living styles(physical exercise,diet&chronic diseases),and genetic factor(ApoE),associated with CI onset.Conclusions:This study confirms the high prevalence of CI among the elderly population in the Shanghai urban in China,similar to previous epidemiologic studies in Western countries.The putative risk factors associated with CI merit further investigated. | Jun-Peng Zhuang Gang Wang Qi Cheng Li-Ling Wang Rong Fang Li-Hua Liu Ran Xiong Yu Zhang Ya-Xing Gui Wen-Yan Kang Hui-Dong Tang Sheng-Di Chen | 2012 | Translational Neurodegeneration2012，1，1： | 10 |
| 14 | Carcinogenic potential of duodenal reflux juice from patients with long-standing postgastrectomy显示文摘AIM To determine, whether study on thecarcinogenic potential of reflux juice frompatients with remote gastrectomy could clarifythe inherent relationship between duodenalreflux and gastric stump cancer.METHODS A total of 37 reflux juice samples(13 Billroth T, 24 Billroth Ⅱ ) were employed inthe present study. A two- stage transformationassay using BALB/c 3T3 cells was carried out totest the initiating or promoting activity of thesesamples.RESULTS Two of 18 (11.1%) reflux samplesexerted initiating activities, whereas 9/19(47.4%) samples enhanced the MNNG-initiafingcell transformation, suggesting the duodenalreflux juice might more frequently possess thetumor-promoter activity (P = 0. 029). In addition,there was no difference in initiating activities ofthe samples irrespective of surgical procedures(P=0.488), while Billroth Ⅱ samples exhibitedstronger tumor-promoter activity than Billroth Ⅰsamples (P = 0.027). Furthermore, the promoteractivities were well correlated with thehistological changes of the stomas (rs = 0.625,P = 0.004), but neither their cytotoxicities norinitiating activities had this correlation( Probabilities were 0.523 and 0.085,respectively).CONCLUSION The duodenal reflux juice frompatients with remote postgastrectomy did havecarcinogenic potential, and suggested thattumor-promoting activity should principallyaccount for the high incidence of gastric cancerin gastrectomy patients. In contrast, it isdifficult to explain the high stump-cancerincidence with the 'N-nitroso compounds'theory-a popular theory for the intact stomachcarcinogenesis, and it seemed to be justified tofocus chemoprevention of this cancer on thetumor-promoting potential of reflux juice. | Zhe Fu Ma~1 Zhong Yu Wang~1 Jun Ran Zhang~2 Peng Gong~1 Hai Long Chen~1 ~1Departrnent of General Surgery,First Hospital,Dalian Medical University,Dalian 116011,China ~2Department of Radiation Oncology,Massachusetts General Hospital and Harvard Medical School,Charlestown,MA 02129,USADr.Zhe Fu Ma graduated from Shanxi Medical College in 1993,nowPh.D.,M.D.in Department of Surgery,Dalian Medical University,majoring gastroenteric cancer,having 4 papers published.Correspondence to:Dr.Zhe Fu Ma.Department of General Surgery,First Hospital,Dalian Medical University,Dalian 116011,China Tel.0086-411-4720334 | 2001 | World Journal of Gastroenterology2001，7，3： | 9 |
| 15 | Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis显示文摘背景几研究评估了在在多样的人口,但是与冲突在各个分享相对小的样品的 results.By 的酶和肺癌症风险学习的编码切除修理十字互补组 1 的多型性( ERCC1 )之间的协会,由严密 methods.Methods Embase 执行证据的元分析是可能的,奥维德, Medline 和中国国家知识基础结构被寻找。另外的研究在原来的研究或评论文章从参考书被识别。满足包括标准的文章系统地被考察,并且报导数据用我们从七合格研究与肺癌症和 4332 控制发现了 3810 个案例的 meta-analysis.Results 的统计技术被聚集。T19007C 多型性没在肺癌症风险上显示出重要效果(C 等位基因对 T 等位基因:机会比率(或)=0.91, 95% 信心间隔(CI )=0.80-1.04;CC 对 TT:OR=0.76, 95% CI=0.56-1.02;CC 对(CT+TT ) :OR=0.96, 95% CI=-0.84-1.10 ) 。同样,当成层时,为肺癌症风险上的 T19007C 多型性没有重要主要效果由种族(汉语或白种人) 的分析。没有重要协会在 C8092A 多型性(3060 个病人和 2729 控制) 和肺癌症的风险之间被发现(等位基因对 C 等位基因:OR=1.03, 95% CI=0.95-1.11;AA 对 CC:OR=1.08, 95% CI=-0.88-1.33;AA 对(AC+CC ) :OR=1.08, 95% CI=-0.88-1.31 ) 我们几乎没在白种人或汉中国人民发现在 ERCC 1 的 T1900C 或 C8092A 多型性和肺癌症的风险之间的一个协会的小证据的 .Conclusion。 | CAO Chao ZHANG Yan-mei WANG Ran SUN Shi-fang CHEN Zhong-bo MA Hong-ying YU Yi-ming DING Qun-li SHU Li-hua DENG Zai-chun | 2011 | Chinese Medical Journal2011，，14： | 9 |
| 16 | Electroacupuncture preconditioning attenuates ischemic brain injury by activation of the adenosine monophosphate-activated protein kinase signaling pathway显示文摘Electroacupuncture has therapeutic effects on ischemic brain injury, but its mechanism is still poorly understood. In this study, mice were stimulated by electroacupuncture at the Baihui(GV20) acupoint for 30 minutes at 1 m A and 2/15 Hz for 5 consecutive days. A cerebral ischemia model was established by ligating the bilateral common carotid artery for 15 minutes. At 72 hours after injury, neuronal injury in the mouse hippocampus had lessened, and the number of terminal deoxynucleotide transferase-mediated d UTP nick-end labeling-positive cells reduced after electroacupuncture treatment. Moreover, expression of adenosine monophosphate-activated protein kinase α(AMPKα) and phosphorylated AMPKα was up-regulated. Intraperitoneal injection of the AMPK antagonist, compound C, suppressed this phenomenon. Our findings suggest that electroacupuncture preconditioning alleviates ischemic brain injury via AMPK activation. | Qiang-qiang Ran Huai-long Chen Yan-li Liu Hai-xia Yu Fei Shi Ming-shan Wang | 2015 | Neural Regeneration Research2015，10，7： | 9 |
| 17 | Effects of five-year intensive multifactorial intervention on the serum amyloid A and macroangiopathy in patients with short-duration type 2 diabetes meUitus显示文摘背景 A 集中的 multifactorial 干预的五年的后续学习被承担估计淀粉的 A ( SAA )铺平的传播浆液和动脉粥样硬化的发生的变化(作为)在有短持续时间的类型的病人没有 maoroangiopathy 的 2 糖尿病 mellitus ( T2DM ),并且集中的 multifactorial 干预是否能与短持续时间的 T2DM 在 150 个病人之中阻止或至少推迟 macroangiopathy.Methods 的 occurence , 75 被分配收到常规门诊病人 | DU Jian-ling LIU Jian-feng MEN Li-li YAO Jun-jie SUN Li-peng SUN Guo-hua SONG Gui-rong YANG Yu BAI Ran XING Qian LI Chang-chen SUN Chang-kai | 2009 | Chinese Medical Journal2009，，21： | 9 |
| 18 | Total knee arthroplasty for treatment of post-traumatic arthritis: Systematic review显示文摘AIM To review and report functional outcomes, complications,and survivorship associated with total knee arthroplasty(TKA) in the treatment of post-traumatic arthritis(PTA).METHODS We conducted a systematic review according to the PRISMA guidelines. We searched PubMed, Cochrane Library, and SCOPUS in December 2015 for Englishlanguage clinical research studies, both prospective and retrospective, examining the use of TKA for the treatment of PTA. All relevant articles were accessed in full. The manual search included references of retrieved articles.We extracted data on patients' demographics and clinical outcomes, including preoperative diagnosis and pre- and post-operative functional scores. We summarized the data and reported the results in tables and text.RESULTS Sixteen studies, four prospective and ten retrospective,examined patients who underwent TKA for PTA due to fractures of the proximal tibia, patella, and/or distal femur. Eleven studies utilized the Knee Society Scores criteria to assess functional outcomes. All studies utilizing these criteria reported an improvement in functional and knee scores of patients following TKA. Further, studies reported an increased range of motion(ROM) and reduction of pain following surgery. The most commonly reported complications with TKA included infection, stiffness, wound complications, intraoperative rupture of tendons, and osteolysis/polyethylene wear. The overwhelming majority of these complications occurred within the first two years following surgery. Six studies examined the survivorship of TKA with subsequent revision for any reason as an endpoint. Compared to patients with osteoarthritis, patients with PTA required more revisions, the majority for polyethylene wear.CONCLUSION Although associated with higher complication rates,TKA is an effective treatment for PTA, as it improves ROM, pain and functional outcomes. | Hesham Saleh Stephen Yu Jonathan Vigdorchik Ran Schwarzkopf | 2016 | World Journal of Orthopedics2016，7，9： | 9 |
| 19 | Risks faced by donors of right lobe for living donor liver transplantation显示文摘BACKGROUND:Because of the shortage of deceased donors with livers fit for transplantation,living donor liver transplantation(LDLT)is becoming an attractive alternative.Attention should be paid to the donors,especially to those of the right lobe.In this study,we evaluated the risks faced by donors of the right lobe for adult-to-adult LDLT.METHODS:The perioperative data from 105 consecutive living donors of the right lobe performed in West China Hospital from January 2002 to December 2007 were retrospectively studied.Preoperative evaluation included CT,MRCP,and intraoperative cholangiography,showing liver volume,hepatic vasculature and the biliary system.The standard liver volume(SLV)and the ratio of left lobe volume to SLV were calculated.The right lobe grafts were obtained by transecting the liver on the right side of the middle hepatic vein without inflow vascular occlusion,using an ultrasonic dissector.After operation the donors were monitored in the Intensive Care Unit for about three days.Each donor was followed up for at least 6 months.RESULTS:There was no donor mortality.Major complications occurred in 14 donors(13.3%),of whom 3 received conservative treatment,8 required invasive paracentesis,and 3 required further surgery.All donors were recovered well and resumed their previous occupations.CONCLUSIONS:Donors of the right lobe face low risks.The preoperative evaluation,especially evaluation of the volume of the remnant liver,should be exact.During the operation,the patency of the remnant hepatic vasculature and bile duct must be preserved,and the extent of injury to the remnant liver should be limited as much as possible.The detection and treatment of postoperative complications should be diligently performed. | Ran, Shun Wen, Tian-Fu Yan, Lu-Nan Li, Bo Zeng, Yong Chen, Zhe-Yu Zhang, Yu Liao, Zhi-Xue Liang, Guan-Lin Li, Guo Zhang, Xian-Hua | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 20 | Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma显示文摘Glioblastoma(GBM)is an incurable and highly heterogeneous brain tumor,originating from human neural stem/progenitor cells(hNSCs/hNPCs)years ahead of diagnosis.Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels,the de novo gliomagenic path from hNSCs is largely unknown due to technical difficulties in early-stage sampling and preclinical modeling.Here,we established two highly penetrant hNSC-derived malignant glioma models,which resemble the histopathology and transcriptional heterogeneity of human GBM.Integrating time-series analyses of whole-exome sequencing,bulk and single-cell RNA-seq,we reconstructed gliomagenic trajectories,and identified a persistent NSC-like population at all stages of tumorigenesis.Through trajectory analyses and lineage tracing,we showed that tumor progression is primarily driven by multi-step transcriptional reprogramming and fate-switches in the NSC-like cells,which sequentially generate malignant heterogeneity and induce tumor phenotype transitions.We further uncovered stage-specific oncogenic cascades,and among the candidate genes we functionally validated C1QL1 as a new glioma-promoting factor.Importantly,the neurogenic-to-gliogenic switch in NSC-like cells marks an early stage characterized by a burst of oncogenic alterations,during which transient AP-1 inhibition is sufficient to inhibit gliomagenesis.Together,our results reveal previously undercharacterized molecular dynamics and fate choices driving de novo gliomagenesis from hNSCs,and provide a blueprint for potential early-stage treatment/diagnosis for GBM. | Xiaofei Wang Ran Zhou Yanzhen Xiong Lingling Zhou Xiang Yan Manli Wang Fan Li Chuanxing Xie Yiming Zhang Zongyao Huang Chaoqiong Ding Kaidou Shi Weida Li Yu Liu Zhongwei Cao Zhen-Ning Zhang Shengtao Zhou Chong Chen Yan Zhang Lu Chen Yuan Wang | 2021 | Cell Research2021，31，6： | 8 |
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