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| 1 | Root microbiota shift in rice correlates with resident time in the field and developmental stage显示文摘Land plants in natural soil form intimate relationships with the diverse root bacterial microbiota. A growing body of evidence shows that these microbes are important for plant growth and health. Root microbiota composition has been widely studied in several model plants and crops; however, little is known about how root microbiota vary throughout the plant's life cycle under field conditions. We performed longitudinal dense sampling in field trials to track the time-series shift of the root microbiota from two representative rice cultivars in two separate locations in China. We found that the rice root microbiota varied dramatically during the vegetative stages and stabilized from the beginning of the reproductive stage, after which the root microbiota underwent relatively minor changes until rice ripening. Notably, both rice genotype and geographical location influenced the patterns of root microbiota shift that occurred during plant growth. The relative abundance of Deltaproteobacteria in roots significantly increased overtime throughout the entire life cycle of rice, while that of Betaproteobacteria, Firmicutes, and Gammaproteobacteria decreased. By a machine learning approach, we identified biomarker taxa and established a model to correlate root microbiota with rice resident time in the field(e.g., Nitrospira accumulated from 5 weeks/tillering in field-grown rice). Our work provides insights into the process of rice root microbiota establishment. | Jingying Zhang Na Zhang Yong-Xin Liu Xiaoning Zhang Bin Hu Yuan Qin Haoran Xu Hui Wang Xiaoxuan Guo Jingmei Qian Wei Wang Pengfan Zhang Tao Jin Chengcai Chu Yang Bai | 2018 | Science China(Life Sciences)2018，61，6： | 24 |
| 2 | The first all-season sample set for mapping global land cover with Landsat-8 data显示文摘We report the world's first all-season training and validation sample sets for global land cover classification with Landsat-8 data.Prior to this,such samples were only available at a single date primarily from the growing season.It is unknown how much limitation such a single-date sample has to mapping global land cover in other seasons of the year.To answer this question,we selected available Landsat-8 images from four seasons and collected training and validation samples from them.We compared the performances of training samples in different seasons using Random Forest algorithm.We found that the use of training samples from any individual season would result in the best overall classification accuracy when validated by samples in the same season.The global overall accuracy from combined best seasonal results was 67.2% when classifying the 11 Level-1 classes in the Finer Resolution Observation and Monitoring of Global Land Cover(FROM-GLC) classification system.The use of training samples from all seasons(named all-season training sample set hereafter) produced an overall accuracy of 67.0%.We also tested classification within 10° latitude 60° longitude zones using all-season training subsample within each zone and obtained an overall accuracy of 70.2%.This indicates that properly grouped subsamples in space can help improve classification accuracies.All the results in this study seem to suggest that it is possible to use an all-season training sample set to reach global optimality with universal applicability in classifying images acquired at any time of a year for global land cover mapping. | Congcong Li Peng Gong Jie Wang Zhiliang Zhu Gregory S. Biging Cui Yuan Tengyun Hu Haiying Zhang Qi Wang Xuecao Li Xiaoxuan Liu Yidi Xu Jing Guo Caixia Liu Kwame O. Hackman Meinan Zhang Yuqi Cheng Le Yu Jun Yang Huabing Huang Nicholas Clinton | 2017 | Science Bulletin2017，62，7： | 21 |
| 3 | A practical guide to amplicon and metagenomic analysis of microbiome data显示文摘Advances in high-throughput sequencing(HTS)have fostered rapid developments in the field of microbiome research,and massive microbiome datasets are now being generated.However,the diversity of software tools and the complexity of analysis pipelines make it difficult to access this field.Here,we systematically summarize the advantages and limitations of microbiome methods.Then,we recommend specific pipelines for amplicon and metagenomic analyses,and describe commonly-used software and databases,to help researchers select the appropriate tools.Furthermore,we introduce statistical and visualization methods suitable for microbiome analysis,including alpha-and betadiversity,taxonomic composition,difference comparisons,correlation,networks,machine learning,evolution,source tracing,and common visualization styles to help researchers make informed choices.Finally,a stepby-step reproducible analysis guide is introduced.We hope this review will allow researchers to carry out data analysis more effectively and to quickly select the appropriate tools in order to efficiently mine the biological significance behind the data. | Yong-Xin Liu Yuan Qin Tong Chen Meiping Lu Xubo Qian Xiaoxuan Guo Yang Bai | 2021 | Protein & Cell2021，12，5： | 20 |
| 4 | An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots显示文摘改变根建筑学是到磷酸盐(Pi ) 的植物的主要发展回答缺乏并且被认为在表层土为可得到的 Pi 提高一个植物能力到牧草。然而,控制这回答的内在的机制糟糕被理解。在这研究,我们识别了 Arabidopsis 异种, hps10 (对 Pi 饥饿 10 过分敏感) ,它在 Pi 足够的状况下面是词法上正常的,但是在 Pi 下面显示出主要的根生长和侧面的根的提高的生产的增加的抑制缺乏。hps10 是 ALUMINUM SENSITIVE3 (ALS3 ) 基因的以前识别的等位基因(als3-3 ) ,它涉及植物忍耐到铝毒性。我们的结果证明 ALS3 和它的交往的蛋白质 AtSTAR1 在 tonoplast 形成 ABC transporter 建筑群。这蛋白质建筑群调停一高度在 Xenopus 卵母细胞的 electrogenic 运输。在 Pi 缺乏下面, als3 比野类型在它的根积累 Fe 3+ 的高水平。在 Arabidopsis, LPR1 (低磷酸盐 ROOT1 ) 和 LPR2 编码 ferroxidases,当变异时,它在根和原因根生长减少 Fe 3+ 累积对 Pi 缺乏感觉迟钝。这里,我们提供证明 ALS3 与 LPR1/2 合作调整 Pi 的引人注目的证据在根的由 modulating Fe 动态平衡的根建筑学的导致缺乏的改变。 | Jinsong Dong Miguel A. PiSeros Xiaoxuan Li Haibing Yang Yu Liu Angus S. Murphy Leon V. Kochian Dong Liu | 2017 | Molecular Plant2017，10，2： | 13 |
| 5 | Annual 30-m land use/land cover maps of China for 1980–2015 from the integration of AVHRR, MODIS and Landsat data using the BFAST algorithm显示文摘Annual land use land cover(LULC)change information at medium spatial resolution(i.e.at 30 m)is required in numerous subjects,such as biophysical modelling,land management and global change studies.Annual LULC information,however,is usually not available at continental or national scale due to reasons such as insufficient remote sensing data coverage or lack of computational capabilities.Here we integrate high temporal resolution and coarse spatial resolution satellite images(i.e.,Moderate Resolution Imaging Spectroradiometer(MODIS)and Global Inventory Modelling and Mapping Studies(GIMMS)normalized difference vegetation index(NDVI))with high spatial resolution datasets(China’s Land-Use/cover Datasets(CLUDs)derived from 30-meter Landsat TM/ETM+/OLI)to generate reliable annual nominal 30 m LULC maps for the whole of China between 1980 and 2015.We also test the performance of a statistical based change detection algorithm(Breaks for Additive Seasonal and Trend),originally designed for tracking forest change,in classifying all-type LULC change.As a result,a nominal 30 m annual land use/land cover datasets(CLUD-A)from 1980 to 2015 was developed for the whole China.The mapping results were assessed with a change sample dataset,a regional annual validation sample set and a three-year China sample set.Of the detected change years,75.61%matched the exact time of conversion within±1 year.Annual mapping results provided a detail process of urbanization,deforestation,afforestation,water and cropland dynamics over the past 36 years.The consistent characterization of land change dynamics for China can be further used in scientific research and to support land management for policy-makers. | Yidi XU Le YU Dailiang PENG Jiyao ZHAO Yuqi CHENG Xiaoxuan LIU Wei LI Ran MENG Xinliang XU Peng GONG | 2020 | Science China Earth Sciences2020，63，9： | 12 |
| 6 | Optimal search for moving targets with sensing capabilities using multiple UAVs显示文摘This paper studies the problem of using multiple unmanned air vehicles(UAVs) to search for moving targets with sensing capabilities. When multiple UAVs(multi-UAV) search for a number of moving targets in the mission area, the targets can intermittently obtain the position information of the UAVs from sensing devices, and take appropriate actions to increase the distance between themselves and the UAVs. Aiming at this problem, an environment model is established using the search map, and the updating method of the search map is extended by considering the sensing capabilities of the moving targets. A multi-UAV search path planning optimization model based on the model predictive control(MPC) method is constructed, and a hybrid particle swarm optimization algorithm with a crossover operator is designed to solve the model. Simulation results show that the proposed method can effectively improve the cooperative search efficiency and can find more targets per unit time compared with the coverage search method and the random search method. | Xiaoxuan Hu Yanhong Liu Guoqiang Wang | 2017 | Journal of Systems Engineering and Electronics2017，28，3： | 8 |
| 7 | Remaining useful life prediction based on variation coefficient consistency test of a Wiener process显示文摘High-cost equipment is often reused after maintenance, and whether the information before the maintenance can be used for the Remaining Useful Life(RUL) prediction after the maintenance is directly determined by the consistency of the degradation pattern before and after the maintenance.Aiming at this problem, an RUL prediction method based on the consistency test of a Wiener process is proposed.Firstly, the parameters of the Wiener process estimated by Maximum Likelihood Estimation(MLE) are proved to be biased, and a modified unbiased estimation method is proposed and verified by derivation and simulations.Then, the h statistic is constructed according to the reciprocal of the variation coefficient of the Wiener process, and the sampling distribution is derived.Meanwhile, a universal method for the consistency test is proposed based on the sampling distribution theorem, which is verified by simulation data and classical crack degradation data.Finally, based on the consistency test of the degradation model, a weighted fusion RUL prediction method is presented for the fuel pump of an airplane, and the validity of the presented method is verified by accurate computation results of real data, which provides a theoretical and practical guidance for engineers to predict the RUL of equipment after maintenance. | Juan LI Bo JING Hongde DAI Xiaoxuan JIAO Xiaodong LIU | 2018 | Chinese Journal of Aeronautics2018，31，1： | 5 |
| 8 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
| 9 | A biomimetic bi-layered tissue engineering scaffolds for osteochondral defects repair显示文摘Osteochondral defects are most commonly characterized by damages to both cartilage and underlying subchondral bone tissues,thus developing bi-layered scaffold that can concurrently regenerate these two specific lineages becomes challenge.In this study,the highly biomimetic bi-layered scaffolds were successfully prepared using human-like-collagen(HLC),hyaluronan(HA)and nano hydroxyapatite(HAP)particles,combined with'liquid phase synthesis'technology,freeze-drying and chemical crosslinking techniques,which was simulated the composition of natural extracellular matrix to repair osteochondral defects.This novel bilayer osteochondral graft had a seamlessly integrated layer structure,suitable pore size,high levels of porosity,and excellent mechanical properties.In vitro cell experiments of the bilayer scaffold indicated that the scaffold could promote the proliferation and adhesion of human bone marrow mesenchymal stem cells.In vivo osteochondral defects and micro-CT experiment revealed that bilayer scaffolds showed complete closure of the defect.Histology confirmed collagen and glycosaminoglycans were deposited in the new matrix of hyaline cartilage and bone in the bilayer scaffold group.Therefore,the developed bionic bilayer scaffold enhanced the regeneration of hyaline cartilage through subchondral bone formation and lateral host-tissue integration.In conclusion,this bilayer scaffold based on HLC could be used as the desired strategy for osteochondral defects regeneration. | LIU KaiQiang LIU YanNan DUAN ZhiGuang MA XiaoXuan FAN DaiDi | 2021 | Science China(Technological Sciences)2021，64，4： | 4 |
| 10 | Host-Associated Quantitative Abundance Profiling Reveals the Microbial Load Variation of Root Microbiome显示文摘Plant-associated microbes are critical for plant growth and survival under natural environmental conditions.To date,most plant microbiome studies involving high-throughput amplicon sequencing have focused on the relative abundance of microbial taxa.However,this technique does not assess the total microbial load and the abundance of individual microbes relative to the amount of host plant tissues.Here,we report the development of a host-associated quantitative abundance profiling(HA-QAP)method that can accurately examine total microbial load and colonization of individual root microbiome members relative to host plants by the copy-number ratio of microbial marker gene to plant genome.We validate the HAQAP method using mock experiments,perturbation experiments,and metagenomic sequencing.The HA-QAP method eliminates the generation of spurious outputs in the classical method based on microbial relative abundance,and reveals the load of root microbiome to host plants.Using the HA-QAP method,we found that the copy-number ratios of microbial marker genes to plant genome range from 1.07 to 6.61 for bacterial 16S rRNA genes and from 0.40 to 2.26 for fungal internal transcribed spacers in the root microbiome samples from healthy rice and wheat.Furthermore,using HA-QAP we found that an increase in total microbial load represents a key feature of changes in root microbiome of rice plants exposed to drought stress and of wheat plants with root rot disease,which significantly influences patterns of differential taxa and species interaction networks.Given its accuracy and technical feasibility,HA-QAP would facilitate our understanding of genuine interactions between root microbiome and plants. | Xiaoxuan Guo Xiaoning Zhang Yuan Qin Yong-Xin Liu Jingying Zhang Na Zhang Kun Wu Baoyuan Qu Zishan He Xin Wang Xinjian Zhang Stephane Hacquard Xiangdong Fu Yang Bai | 2020 | Plant Communications2020，1，1： | 3 |
| 11 | Fine particulate matter(PM_(2.5)/PM_(1.0)) in Beijing,China: Variations and chemical compositions as well as sources显示文摘Particulate matter(i.e.,PM_(1.0) and PM_(2.5)),considered as the key atmospheric pollutants,exerts negative effects on visibility,global climate,and human health by associated chemical compositions.However,our understanding of PM and its chemical compositions in Beijing under the current atmospheric environment is still not complete after witnessing marked alleviation during 2013–2017.Continuous measurements can be crucial for further air quality improvement by better characterizing PM pollution and chemical compositions in Beijing.Here,we conducted simultaneous measurements on PM in Beijing during 2018–2019.Results indicate that annualmean PM_(1.0) and PM_(2.5) concentrations were 35.49±18.61μg/m^(3) and 66.58±60.17μg/m^(3),showing a positive response to emission controls.The contribution of sulfate,nitrate,and ammonium(SNA)played an enhanced role with elevated PM loading and acted as the main contributors to pollution episodes.Discrepancies observed among chemical species between PM_(1.0) and PM_(2.5) in spring suggest that sand particles trend to accumulate in the range of 1–2.5μm.Pollution episodes occurred accompanied with southerly clusters and high formation of SNA by heterogeneous reactions in summer and winter,respectively.Results from positive matrix factorization(PMF)combined with potential source contribution function(PSCF)models showed that potential areas were seasonal dependent,secondary and vehicular sources became much more important compared with previous studies in Beijing.Our study presented a continuous investigation on PM and sources origins in Beijing,which provides a better understanding for further emission control as well as a reference for other cities in developing countries. | Lining Luo Xiaoxuan Bai Shuhan Liu Bobo Wu Wei Liu Yunqian Lv Zhihui Guo Shumin Lin Shuang Zhao Yan Hao Jiming Hao Kai Zhang Aihua Zheng Hezhong Tian | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 12 | Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers显示文摘Ginsenosides are the main pharmacologically active constituents of ginseng which have been used in East Asian countries for centuries to modulate blood pressure,metabolism and immune function.Following the technological advances in isolation,purification and mass production,their mechanisms of action are gradually elucidated,providing solid basis for clinical applications.Ginseng extracts(total ginsenosides)and ginsenoside Rg3,CK,Rd have been marketed or entered clinical trials as drugs or dietary supplements.Despite the proven safety and efficacy of some ginsenosides,their applications are hindered by inferior pharmacokinetics such as low solubility,poor membrane permeability and metabolic instability.Nanoparticle formulation of drugs and implantable drug depots are effective strategies to improve the pharmacokinetics of therapeutic agents by enhancing solubility,providing protection,facilitating intracellular transport,and enabling sustained and controlled release.This mini-review summarizes the recent advances in systemic delivery of ginsenosides using liposomes,micelles,albumin-based nanoparticles,and inorganic nanoparticles,as well as local delivery of ginsenosides by electronspun fibrous membranes and hydrogels. | Jing Zhao Zhiguang Duan Xiaoxuan Ma Yannan Liu Daidi Fan | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 3 |
| 13 | A putative bHLH transcription factor is a candidate gene for male sterile 32,a locus affecting pollen and tapetum development in tomato显示文摘The tomato(Solanum lycopersicum)male sterile 32(ms32)mutant has been used in hybrid seed breeding programs largely because it produces no pollen and has exserted stigmas.In this study,histological examination of anthers revealed dysfunctional pollen and tapetum development in the ms32 mutant.The ms32 locus was fine mapped to a 28.5 kb interval that encoded four putative genes.Solyc01g081100,a homolog of Arabidopsis bHLH10/89/90 and rice EAT1,was proposed to be the candidate gene of MS32 because it contained a single nucleotide polymorphism(SNP)that led to the formation of a premature stop codon.A codominant derived cleaved amplified polymorphic sequence(dCAPS)marker,MS32D,was developed based on the SNP.Real-time quantitative reverse-transcription PCR showed that most of the genes,which were proposed to be involved in pollen and tapetum development in tomato,were downregulated in the ms32 mutant.These findings may aid in marker-assisted selection of ms32 in hybrid breeding programs and facilitate studies on the regulatory mechanisms of pollen and tapetum development in tomato. | Xiaoyan Liu Mengxia Yang Xiaolin Liu Kai Wei Xue Cao Xiaotian Wang Xiaoxuan Wang Yanmei Guo Yongchen Du Junming Li Lei Liu Jinshuai Shu Yong Qin Zejun Huang | 2019 | Horticulture Research2019，6，1： | 3 |
| 14 | Targeted nanoparticles for precise cancer therapy显示文摘Cancer has become one of the biggest challenges in the development of modern medical science. In particular, many problems, such as low efficiency, severe side effects, metastasis, and tumor invasion, challenge the development of precise cancer therapy. Continuous advancements in medicine, however, have allowed clear differentiation between tumors and normal tissues that can be exploited for cancer therapeutics. Unlike normal cells, tumor cells have an uncontrollable growth and are infinitely proliferative. These physical, chemical, and biological differences (e.g., metabolic states, high cell density, ability to grow in hypoxic and low pH conditions, and expression of different specific receptors/ ligands) may provide a new perspective for the development of cancer therapeutics. Traditional antitumor drugs have disadvantages, such as poor solubility, insufficient bioavailability in the body, numerous side effects, and development of chemoresistance, all of which greatly limit their therapeutic efficacy. | Jinjin Wang Yongchao Wang Ruifang Wang Shouwen Zhang Xiaoxuan Liu Xing-Jie Liang | 2019 | Science China(Life Sciences)2019，62，10： | 2 |
| 15 | Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma显示文摘 | Shiren Sun Xiaoxuan Ning Jie Liu Lili Liu Yu Chen Shuang Han Yanqi Zhang Jie Liang Kaichun Wu Daiming Fan | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 2 |
| 16 | Application and Experience of Putting People First in Hospital Human Resource Management显示文摘The recent years have witnessed the rapid economic growth of our country.The medical industry has also come to a new era.The number of hospital staff continues to increase,while some problems of managing human resource have gradually emerged.These problems have a bad impact on the functions of the hospital.We must attach great importance to solve them.In the process of managing the human resources of hospital,we must insist to put people first.That is how we can better boost the working initiative of medical staff,setting the foundation for the development of hospital in a long run.This article has conducted deepening research on this issue.First of all,it briefly introduced the theory of putting people first.And then it stated the connotation of the theory of putting people first applied in managing human resources of hospital.At last,it explored the strategies on applying the theory of putting people first in managing human resources of hospital in accordance to the concrete conditions. | Tao Zhou Xiaoxuan Liu Wei Yu Xinke Wang Hao Teng | 2020 | Proceedings of Anticancer Research2020，4，6： | 2 |
| 17 | To Blame or Not?Modulating Third-Party Punishment with the Framing Effect显示文摘People as third-party observers,without direct self-interest,may punish norm violators to maintain social norms.However,third-party judgment and the follow-up punishment might be susceptible to the way we frame(i.e.,verbally describe)a norm violation.We conducted a behavioral and a neuroimaging experiment to investigate the above phenomenon,which we call the“third-party framing effect”.In these experiments,participants observed an anonymous perpetrator deciding whether to keep her/his economic benefit while exposing a victim to a risk of physical pain(described as“harming others”in one condition and“not helping others”in the other condition),then they had a chance to punish that perpetrator at their own cost.Our results showed that the participants were more willing to execute third-party punishment under the harm frame compared to the help frame,manifesting a framing effect.Self-reported anger toward perpetrators mediated the relationship between empathy toward victims and the framing effect.Meanwhile,activation of the insula mediated the relationship between mid-cingulate cortex activation and the framing effect;the functional connectivity between these regions significantly predicted the size of the framing effect.These findings shed light on the psychological and neural mechanisms of the third-party framing effect. | Jiamiao Yang Ruolei Gu Jie Liu Kexin Deng Xiaoxuan Huang Yue-Jia Luo Fang Cui | 2022 | Neuroscience Bulletin2022，38，5： | 2 |
| 18 | Reactive-HALS I: Synthesis,Characterization,Copolymerization Reactivity and Photo-stabilizing Performance Applied in UV-curable Coatings显示文摘 | Jianwen YANG and Yonglie CHEN | 2002 | Polymers for Advanced Technologies2002，13，34： | 1 |
| 19 | Efficiency,technical progress,and best practice in Chinese state enterprises(1980-1994)显示文摘 | JINGHAI ZHENG XIAOXUAN LIU ARNE BIGSTEN | 2003 | Journal of Comparative Economics2003，31，： | 1 |
| 20 | Ownership structure and determinants and technical efficiency: an application of DEA to Chinese enterprises 显示文摘 | ZHENG Jinhai LIU Xiaoxuan and Bigsten A | 2003 | Journal of Comparative Economics2003，26，： | 1 |
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