|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Diffusion tensor MRI of the human kidney显示文摘 | Ries M Jones RA Basseau F | 2001 | J Magn Reson Imaging2001，14，1： | 1 |
| 4 | Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels显示文摘 | Jobonson RA Zhang F | 1999 | Am J Physiol1999，276，42： | 1 |
| 5 | Anti-CD18 attenuates deleterious effects of cardio-pulmonary bypass and hypothermic circulatory arrest in piglets显示文摘 | Aoki M Jonas RA Nomura F | 1995 | J Card Surg1995，10，： | 1 |
| 6 | Changes in limb dynamics during the practice of rapid arm movements 显示文摘 | Schneider K Zernicke R F Schmidt RA | 1989 | J Biomech1989，22，89： | 1 |
| 7 | Human osteogenic protein-1 induces osteogenic differentiation of adipose-derived stem cells harvested from mice显示文摘 | A1-Salleeh F Beatty MW Reinhardt RA | 2008 | Arch Oral Biol2008，53，10： | 1 |
| 8 | Assessment of quality of lifein patients undergoing orthognathic surgery 显示文摘 | Bock JJ Odemar F Fuhrmann RA | 2009 | J Orofac Orthop2009，70，5： | 1 |
| 9 | Nutritional status in patients with chronic respiratory failure receiving home mechanical ventilation:impact on survival显示文摘 | Hitzl AP Jorres RA Heinemann F | 2010 | Clin Nutr2010，29，1： | 1 |
| 10 | Flavonoids and isoflavonoids from Zollernia paraensis显示文摘 | Ferrari F Botta B de Lima RA | 1983 | Phytochemistry1983，22，7： | 1 |
| 11 | Bevacizttmab with or without erlotinib in metastatic renal cell carcinoma(RCC)显示文摘 | Bukowskl RM Kabbinavar F Figlin RA | 2006 | J Clin Oncol2006，24，18： | 1 |
| 12 | Heat stress-induced H2O2 is required for effective expression of heat shock genes in Arabidopsis显示文摘 | Volkov RA Panchuk II Mullineaux PM Sch(o)effl F | | 0，，4： | 1 |
| 13 | Enzyme-ampli- fied lanthanide luminescence for enzyme detection in bioana- lytical assays显示文摘 | Evangelista RA Poliak A Templeton E F | 1991 | Anal Biochem1991，197，： | 1 |
| 14 | Diffusion tensor M RI of the human kidney显示文摘 | Ries M Jones RA Basseau F | 2001 | Magn Reson Imaging2001，14，： | 1 |
| 15 | Inhibition of Janus kinase3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts 显示文摘 | Behbod F Erwin-Cohen RA Wang ME | 2001 | J Immunol2001，166，6： | 1 |
| 16 | Electrode and electrolyte impedance in the detection of bacterial growth显示文摘 | Hause LL Komorowski RA Gayon F | 1981 | IEEE Transactions on Biomedical Engineering1981，28，5： | 1 |
| 17 | Expandable metallic prostheses for malignant obstructions of gastric outlet and proximal small bowel 显示文摘 | Nevitt AW Vida F Kozarek RA | 1998 | Gastrointest Endosc1998，47，： | 1 |
| 18 | Granular cell tumor of the breast mimicking carcinoma in pregnancy显示文摘 | Kommoss F Mercer L Schmidt RA | 1989 | Obstet Gynecol1989，73，： | 1 |
| 19 | Renal lymphangioma显示文摘 | Castano JC Vélez A Raül Flórez F | 2005 | Arch Esp Urol2005，58，3： | 1 |
| 20 | Viral metagenomics显示文摘 | EDWARDS RA ROHWER F | 2005 | Nat Rev Microbiol2005，3，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员