|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage显示文摘Anabolic steroid abuse is common among athletes and is associated with a number of medical complications. We describe a case of a 27-year-old male bodybuilder with multiple hepatic adenomas induced by anabolic steroids. He initially presented with tumor hemorrhage and was treated with left lateral hepatic segmentectomy. Regression of the remaining tumors was observed with cessation of steroid use. However, 3 years and a half after his initial hepatic segmentectomy, he presented with recurrent tumor enlargement and intraperitoneal hemorrhage in the setting of steroid abuse relapse. Given his limited hepatic reserve, he was conservatively managed with embolization of the right accessory hepatic artery. This is the first reported case of hepatic adenoma re- growth with recidivistic steroid abuse, complicated by life-threatening hemorrhage. While athletes and bodybuilders are often aware of the legal and social ramifications of steroid abuse, they should continue to be counseled about its serious medical risks. | Nicole M Martin Barham K Abu Dayyeh Raymond T Chung | 2008 | World Journal of Gastroenterology2008，14，28： | 3 |
| 2 | FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts显示文摘AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated with poor TTP [hazard ratio (HR): 16.036, P < 0.0001] and OS (HR: 4.003, P = 0.004). CONCLUSION: The FOLFIRI regimen had an acceptable toxicity and an interesting efficacy in our study, limited to patients in good condition (PS 0-1). | Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 3 | Hospital readmissions in decompensated cirrhotics: Factors pointing toward a prevention strategy显示文摘AIM To reduce readmissions and improve patient outcomes in cirrhotic patients through better understanding of readmission predictors.METHODS We performed a single-center retrospective study of patients admitted with decompensated cirrhosis from January 1, 2011 to December 31, 2013(n = 222). Primary outcomes were time to first readmission and 30-d readmission rate due to complications of cirrhosis. Clinical and demographic data were collected to help describe predictors of readmission, along with care coordination measures such as post-discharge status and outpatient follow-up. Univariate and multivariateanalyses were performed to describe variables associated with readmission.RESULTS One hundred thirty-two patients(59.4%) were readmitted at least once during the study period. Median time to first and second readmissions were 54 and 93 d, respectively. Thirty and 90-d readmission rates were 20.7 and 30.1 percent, respectively. Predictors of 30-d readmission included education level, hepatic encephalopathy at index, ALT more than upper normal limit and Medicare coverage. There were no statistically significant differences in readmission rates when stratified by discharge disposition, outpatient follow-up provider or time to first outpatient visit.CONCLUSION Readmissions are challenging aspect of care for cirrhotic patients and risk continues beyond 30 d. More initiatives are needed to develop enhanced, longitudinal post-discharge systems. | Siamak M Seraj Emily J Campbell Sarah K Argyropoulos Kara Wegermann Raymond T Chung James M Richter | 2017 | World Journal of Gastroenterology2017，23，37： | 3 |
| 4 | Atmosphrer - Automatic track mining and objective satellite pattern hunting system using enhanced RBF and EGDLM 显示文摘 | S T L Raymond N K L James | 2000 | AAAI/IAAI2000，3，： | 2 |
| 5 | Distance-Based outliers: Algorithms and Applications 显示文摘 | Edwin M Knorr Raymond T Ng and Vladimir Tucakov | 2000 | The VLDB Journal2000，8，3： | 2 |
| 6 | A systemic granulomatous response to Schistosoma mansoni eggs alters responsiveness of bone- marrow-derived macrophages to Toll-like receptor agonists 显示文摘 | Joshi AD Raymond T Coelho AL | 2008 | J Leukoc Biol2008，83，2： | 1 |
| 7 | Aerobic biodegradation of alkylated aromatic hydrocarbon by a bacterial community 显示文摘 | BUDZINSKI H RAYMOND N NADALIG T | 1998 | Org Geochem1998，28，5： | 1 |
| 8 | Time-scale for adjustment of glaciers to change in mass balance显示文摘 | Johannesson T Raymond C Waddington E | 1989 | Journal of Glaciology1989，35，121： | 1 |
| 9 | Protestant Work Ethic and Worker Productivity in a Mexi- can Brewery 显示文摘 | Firestone M Juanita Raymond T Garza Richard J Harris | 2005 | International Sociology2005，，1： | 1 |
| 10 | Influence of lnterfacial on the Properties of PVC/Cellulosic Fiber Composites 显示文摘 | Laurent M Matuana Raymond T Woodhams John J Balatinecz et ol | 1998 | Polymer Composites1998，19，4： | 1 |
| 11 | Deflects and the photographic process 显示文摘 | Myra T Olm Raymond S Eachus | 1999 | Radiation Effects and Defects in Solid1999，150，： | 1 |
| 12 | Distance-based Outliers:Algorithms and Applications显示文摘 | Edwin M K Raymond T N Vladimir Tucakov | 2000 | VLDB Journal2000，324，8： | 1 |
| 13 | Age at onset as a factorin determining the phenotype of primary torsion dystonia显示文摘 | O'Riordan S Raymond D Lynch T | 2004 | Neurology2004，63，8： | 1 |
| 14 | Acceptabilityand adoption of handheld computer datacollection for public health research in China:a case study显示文摘 | Wan X Raymond HF Wen T | 2013 | BMC Medical Informatics andDecision Making2013，13，1： | 1 |
| 15 | A utility-based approach quantitative adaptation in wireless packet networks显示文摘 | RAYMOND R LIAO F ANDREW T | 2001 | Wireless Networks2001，7，5： | 1 |
| 16 | Influence ofinterfacial on the properties of PVC/cellulosic fiber compo-sites显示文摘 | Laurent M M Raymond T W John J B | 1998 | Polym Compos1998，19，4： | 1 |
| 17 | CLARANS:A method for clustering objects for spatial data mining显示文摘 | Raymond T Han J W | 2002 | IEEE Transactions on Knowledge and Data Engineering2002，14，5： | 1 |
| 18 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 19 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 20 | Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cells responses显示文摘 | Geimonen E Neff S Raymond T | 2002 | PNAS2002，99，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员