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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | Prospective study of differential diagnosis of hepatic tumors by pattern-based classification of contrast-enhanced sonography显示文摘AIM: To prospectively evaluate the usefulness of a pattern-based classification of contrast-enhanced sonographic findings for differential diagnosis of hepatic tumors. METHODS: We evaluated the enhancement pattern of the contrast-enhanced sonography images in 586 patients with 586 hepatic lesions, consisting of 383 hepatocellular carcinomas, 89 metastases, and 114 hemangiomas. After injecting a galactose-palmitic acid contrast agent, lesions were scanned by contrast- enhanced harmonic gray-scale sonography in three phases: arterial, portal, and late. The enhancement patterns of the initial 303 lesions were classified retrospectively, and multiple logistic regression analysis was used to identify enhancement patterns that allowed differentiation between hepatic tumors. We then used the pattern-based classification of enhancement we had retrospectively devised to prospectively diagnose 283 liver tumors. RESULTS: Seven enhancement patterns were found to be significant predictors of different hepatic tumors. The presence of homogeneous or heterogeneous enhancement both in the arterial and portal phase was the typical enhancement pattern for hepatocellular carcinoma, while the presence of peritumoral vessels in the arterial phase and ring enhancement or a perfusion defect in the portal phase was the typical enhancement pattern for metastases, and the presence of peripheral nodular enhancement both in the arterial and portal phase was the typical enhancement pattern forhemangioma. The sensitivity, specificity, and accuracy of prospective diagnosis based on the combinations of enhancement patterns, respectively, were 93.2%, 96.2%, and 94.0% for hepatocellular carcinoma, 87.9%, 99.6%, and 98.2% for metastasis, and 95.6%, 94.1%, and 94.3% for hemangioma. CONCLUSION: The pattern-based classification of the contrast-enhanced sonographic findings is useful for differentiating among hepatic tumors. | Kazushi Numata Tetsuo Isozaki Manabu Morimoto Kazuya Sugimori Reiko Kunisaki Toshio Morizane Katsuaki Tanaka | 2006 | World Journal of Gastroenterology2006，12，39： | 18 |
| 3 | Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations显示文摘瞄准:在胃的区分类型的肿瘤澄清在肿瘤区别显型和肿瘤侵略或基因改变之间的关系。方法:我们检验了肿瘤区别在 48 个胃的腺瘤和 171 区分类型的癌的显型,在 APC 和 p53 的变化的存在,和微卫星不稳定性(MSI ) 地位。肿瘤区别显型被检验人的表示决定胃粘蛋白(HGM ) , MUC6, MUC2 和 CD10。肿瘤然后被分类进胃 --(G-) ,胃、肠混合 --( 官方补给 --) ,或肠 --( 我 --) 显型,根据上述标记的免疫确实。在 APC 和 p53 和 MSI 地位的变化的存在也在所有肿瘤被调查。结果:胃的腺瘤显著地与 CD10 表示,我显型肿瘤和 APC 变化的存在被联系,与癌相比(66.7% 对 25.1% , P <
0.0001;56.3% 对 14.6% , P <
0.0001;39.6% 对 14.0% , P <
0.0001,分别地) 并且相反地与 HGM 和 MUC6 和 p53 变化的存在的表情联系了(10.4% 对 62.6% , P <
0.0001;39.6% 对 64.3% , P = 0.003;2.0% 对 26.3% , P = 0.001,分别地) 。APC 变化的频率在比在 HGM 积极的肿瘤, MUC6 积极的肿瘤, CD10 否定的肿瘤和 G 显型肿瘤的 HGM 否定的肿瘤, MUC6 否定的肿瘤, CD10 积极的肿瘤和我显型肿瘤是显著地更高的(32.7% 对 7.1% , P <
0.0001;27.8% 对 14.0% , P = 0.0182;37.3% 对 10.4% , P <
0.0001;并且 38.5% 对 9.5% , P = 0.0017,分别地) 。MSI 的频率在比在 MUC6 否定的肿瘤, CD10 积极的肿瘤和我显型肿瘤的 MUC6 积极的肿瘤, CD10 否定的肿瘤和 G 显型肿瘤是显著地更高的(24.8% 对 6.7% , P = 0.0009;22.2% 对 8.0% , P = 0.0143;并且 28.6% 对 9.6% , P = 0.0353,分别地) 。结论:肿瘤区别显型是仔细与在胃的区分类型的肿瘤的肿瘤侵略和基因改变有关。 | Kimiyasu Yamazaki Yusuke Tajima Reiko Makino Nobukazu Nishino Shigeo Aoki Masanori Kato Masaaki Sakamoto Koji Morohara Tsutomu Kaetsu Mitsuo Kusano | 2006 | World Journal of Gastroenterology2006，12，24： | 9 |
| 4 | Cholangiopancreatography troubleshooting:the usefulness of endoscopic retrieval of migrated biliary and pancreatic stents显示文摘BACKGROUND:Stent migration in the hepatopancreatic duct might arise as one of the rare complications associated with biliary or pancreatic stenting.Although there are some procedures to retrieve the migrated stent,including surgical,percutaneous,and endoscopic approaches,endoscopy should be attempted first because it is least invasive.This study set out to evaluate the usefulness of endoscopic retrieval of migrated biliary and pancreatic stents.METHODS:Plastic stents that migrated in the bile duct(35 patients)or pancreatic duct(2)were retrieved with endoscopic retrograde cholangiopancreatography.Devices used were snare forceps,a basket catheter,grasping forceps,biopsy forceps,a balloon catheter,and the Soehendra stent retriever.RESULTS:Endoscopic retrieval of migrated stents was performed successfully in 36(97.0%)of the 37 patients.The devices utilized for successful treatment were basket catheter(13 patients),grasping forceps(10),snare forceps(8),balloon catheter(3),biopsy forceps(1),and the Soehendra stent retriever(1).The unsuccessfully treated patient with chronic pancreatitis underwent surgery since the guide wire did not move forward due to bile duct stenosis,and there was also duodenal stenosis.One patient developed mild pancreatitis after withdrawal of the stent;the pancreatitis was relieved with conservative treatment.CONCLUSIONS:Endoscopic retrieval of migrated biliary and pancreatic stents appears to be useful because of its safety and low invasiveness.However,various forceps should be prepared for the retrieval of a migrated stent. | Yuji Sakai Toshio Tsuyuguchi Takeshi Ishihara Harutoshi Sugiyama Reiko Eto Tatsuya Fujimoto Shin Yasui Ryo Tamura Seiko Togo Motohisa Tada Osamu Yokosuka | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 5 | 创新数据非依赖性采集用于复杂基质目标蛋白质的定量分析显示文摘数据非依赖性采集( DIA)是随着定量蛋白质组学而建立的质谱扫描技术。 DIA能够获得扫描范围内所有母离子及二级子离子信息,不会造成低丰度离子信息的丢失,同时突破了高分辨质谱二级定量的通量限制。本研究基于静电场轨道阱Q-qIT-OT三合一质谱,发展了经典DIA方法以及WiSIM-DIA和Full MS-DIA两种全新DIA方法,并对Hela细胞全蛋白中添加的10条低浓度肽段进行定量分析,考察方法的线性、重现性和灵敏度。结果表明,3种方法的定量限均低至amol (14~435 amol),并展示出良好的线性和定性确证可靠性。其中,WiSIM-DIA基于超高分辨一级监测定量,与经典DIA优势互补;Full MS-DIA的选择窗口仅3 amu,能够直接进行搜库鉴定,实现了数据依赖性采集( DDA)和DIA的统一,摆脱了DIA依赖于DDA建立谱图库的局限性。 | 张伟 Reiko Kiyonami 江峥 陈伟 | 2014 | 分析化学2014，42，12： | 6 |
| 6 | H pylori seropositivity and cytokine gene polymorphisms显示文摘AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection. | Yasuaki Saijo Eiji Yoshioka Tomonori Fukui Mariko Kawaharada Fumihiro Sata Hirokazu Sato Reiko Kishi | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 7 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 8 | A Combined Computational and Experimental Study on the Structure-Regulation Relationships of Putative Mammalian DNA Replication Initiator GINS显示文摘GINS, a heterotetramer of SLD5, PSF1, PSF2, and PSF3 proteins, is an emerging chromatin factor recognized to be involved in the initiation and elongation step of DNA replication. Although the yeast and Xenopus GINS genes are well docu- mented, their orthologous genes in higher eukaryotes are not fully characterized. In this study, we report the genomic structure and transcriptional regulation of mammalian GINS genes. Serum stimulation increased the GINS mRNA levels in human cells. Reporter gene assay using putative GINS promoter sequences revealed that the expression of mammalian GINS is regulated by 17β-Estradiol- stimulated estrogen receptor α, and human PSF3 acts as a gene responsive to transcription factor E2F1. The goal of this study is to present the current data so as to encourage further work in the field of GINS gene regulation and functions in mammalian cells. | Reiko Hayashi Takako Arauchi Moe Tategu Yuya Goto Kenichi Yoshida | 2006 | Genomics, Proteomics & Bioinformatics2006，4，3： | 4 |
| 9 | Serum magnesium concentration in children with functional constipation treated with magnesium oxide显示文摘AIM:To determine whether hypermagnesemia recently reported in adult patients possibly develops in children with functional constipation taking daily magnesium oxide.METHODS:We enrolled 120 patients (57 male and 63 female) aged 1-14 years old (median:4.7 years) with functional constipation from 13 hospitals and two private clinics.All patients fulfilled the Rome Ⅲ criteria for functional constipation and were treated with daily oral magnesium oxide for at least 1 mo.The median treatment dose was 600 (500-800) mg/d.Patients were assessed by an interview and laboratory examination to determine possible hypermagnesemia.Serum magnesium concentration was also measured in sex-and agematched control subjects (n=38).RESULTS:In the constipation group,serum magnesium concentration [2.4 (2.3-2.5) mg/dL,median and interquartile range] was significantly greater than that of the control group [2.2 (2.0-2.2) mg/dL] (P < 0.001).The highest value was 3.2 mg/dL.Renal magnesium clearance was significantly increased in the constipation group.Serum magnesium concentration in the constipation group decreased significantly with age (P < 0.01).There was no significant correlation between the serum level of magnesium and the duration of treatment with magnesium oxide or the daily dose.None of the patients had side effects associated with hypermagnesemia.CONCLUSION:Serum magnesium concentration increased significantly,but not critically,after daily treatment with magnesium oxide in constipated children with normal renal function. | Maiko Tatsuki Reiko Miyazawa Takeshi Tomomasa Takashi Ishige Tomoko Nakazawa Hirokazu Arakawa | 2011 | World Journal of Gastroenterology2011，17，6： | 4 |
| 10 | A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients显示文摘 | Noriko Satoh-Asahara Yousuke Sasaki Hiromichi Wada Mayu Tochiya Azusa Iguchi Reiko Nakagawachi Shinji Odori Shigeo Kono Koji Hasegawa Akira Shimatsu | 2012 | Metabolism2012，，： | 3 |
| 11 | Rice-Specific Mitochondrial Iron-Regulated Gene (MIR) Plays an Important Role in Iron Homeostasis显示文摘线粒体利用铁(Fe ) ,但是涉及 mitochondrial Fe 规定的蛋白质没在植物被描绘。我们克隆并且描绘 mitochondrial 调整铁(米尔) 在米饭的基因在 Fe 包含了动态平衡。当在烟草 BY-2 房间表示了时,米尔对线粒体局部性。米尔抄本极大地在根和射击织物响应 Fe 缺乏被增加。当相当或相同的事物没为另外的有机体在米饭或 Arabidopsis 染色体数据库,或在 EST 数据库被发现,米尔不对任何已知的蛋白质相应。在 MIR T-DNA 猛烈米饭异种(米尔) 的生长显著地被损害与相比野类型(WT ) 当在 Fe 缺乏或足够的条件下面成长时,种。而且,多于当在 Fe 足够或缺乏的条件下面成长时,两次在与 WT 相比的射击和根织物的 Fe 的数量种,米尔植物积累了。尽管有在根和射击的 Fe 的高累积,米尔植物触发了 Fe-deficiency-inducible 基因的表达式,显示那米尔不能利用为生理的函数的 Fe。这些结果清楚地建议那米尔是大米特定的 mitochondrial 蛋白质,最近演变,并且在 Fe 动态平衡起一个重要作用。 | Yasuhiro Ishimaru Khurram Bashir Masaru Fujimoto Gynheung An Reiko Nakanishi Itai Nobuhiro Tsutsumi Hiromi Nakanishi Naoko K Nishizawa | 2009 | Molecular Plant2009，2，5： | 3 |
| 12 | Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication显示文摘 | Paul Lochhead Aya Kuchiba Yu Imamura Xiaoyun Liao Mai Yamauchi Reiko Nishihara Zhi Rong Qian Teppei Morikawa Jeanne Shen Jeffrey A. Meyerhardt Charles S. Fuchs Shuji Ogino | 2013 | JNCI Journal of the National Cancer Institute2013，，15： | 3 |
| 13 | Polysomnographic assessment of respiratory disturbance during deep propofol sedation for endoscopic submucosal dissection of gastric tumors显示文摘AIM To investigate that polysomnographic monitoring can accurately evaluate respiratory disturbance incidence during sedation for gastrointestinal endoscopy compare to pulse oximetry alone.METHODS This prospective observational study included 10 elderly patients with early gastric cancer undergoing endoscopic submucosal dissection(ESD) under propofol sedation. Apart from routine cardiorespiratory monitoring, polysomnography measurements were acquired. The primary hypothesis was tested by comparing the apnea hypopnea index(AHI), defined as the number of apnea and hypopnea instances per hour during sedation, with and without hypoxemia; hypoxemia was defined as the reduction in oxygen saturation by ≥ 3% from baseline.RESULTS Polysomnography(PSG) detected 207 respiratory disturbances in the 10 patients. PSG yielded a significantly greater AHI(10.44 ± 5.68/h) compared with pulse oximetry(1.54 ± 1.81/h, P < 0.001), thus supporting our hypothesis. Obstructive AHI(9.26 ± 5.44/h) was significantly greater than central AHI(1.19 ± 0.90/h, P < 0.001). Compared with pulse oximetry, PSG detected the 25 instances of respiratory disturbances with hypoxemia 107.4 s earlier on average.CONCLUSION Compared with pulse oximetry, PSG can better detect respiratory irregularities and thus provide superior AHI values, leading to avoidance of fatal respiratory complications during ESD under propofol-induced sedation. | Ryuma Urahama Masaya Uesato Mizuho Aikawa Yukiko Yamaguchi Koichi Hayano Tomoaki Matsumura Makoto Arai Reiko Kunii Shiroh Isono Hisahiro Matsubara | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 3 |
| 14 | 电针“足三里”或“阳陵泉”对围产期尼古丁暴露新生鼠肺功能和组织形态的影响显示文摘目的:对比电针母鼠'足三里'与'阳陵泉'穴对围产期尼古丁暴露新生鼠肺功能与组织形态学干预效应的差异,探寻电针防护新生鼠肺发育不良的穴位效应规律。方法:将24只雌性SD大鼠随机分为生理盐水组(S组)、尼古丁组(N组)、尼古丁加足三里组(N+ST 36组)和尼古丁加阳陵泉组(N+GB 34组),每组6只。从受孕第6天开始,S组皮下注射0.9%氯化钠溶液(1 mg/kg);其余3组皮下注射等量尼古丁,至子代大鼠出生后第21天制备围产期尼古丁暴露模型。造模同时N+ST 36组和N+GB 34组分别电针'足三里'和'阳陵泉'穴,每天1次,至子代大鼠出生后第21天。采用小动物肺功能分析系统观察新生鼠吸气峰值流速(PIF)、呼气峰值流速(PEF)、呼气阻力(RE)、吸气阻力(RI)和动态顺应性(Cdyn)等肺功能指标变化;采用HE染色观察肺泡融合、破裂程度等肺组织形态学的变化。结果:与S组比较,N组PEF、Cdyn较低,PIF、RI、RE较高(均P<0.01),肺泡融合、破裂,肺泡壁增厚,肺泡数量减少,肺泡间距变大,肺泡直径较大(P<0.01);与N组比较,N+ST 36组PEF、Cdyn较高,PIF、RI、RE较低(P<0.05,P<0.01),肺泡融合、破裂程度有所改善,肺泡数量增多,肺泡壁变薄,肺泡间距正常,肺泡直径显著减少(P<0.01),而N+GB34组肺功能和肺形态各指标变化不明显(P>0.05)。结论:电针围产期尼古丁暴露孕鼠'足三里'较'阳陵泉'更能明显改善新生大鼠肺功能与肺组织形态。 | 苏杭 嵇波 赵国桢 刘翼天 葛云鹏 戴健 路雅雯 王丹 Reiko Sakurai Rehan VK 严明娜 孙晓敏 白红新 郭孟玮 任晓暄 | 2019 | 中国针灸2019，39，6： | 2 |
| 15 | 电针“足三里”穴对孕期及哺乳期尼古丁暴露新生鼠肺发育不良的影响显示文摘目的观察电针'足三里'穴对孕期及哺乳期尼古丁暴露新生鼠肺功能、肺指数和肺组织形态学的影响。方法将20只成年SD雌鼠采用随机数字表法分为生理盐水组(S组)、生理盐水加电针'足三里'组(S+ST36组)、尼古丁组(N组)、尼古丁加电针'足三里'组(N+ST36组),采用皮下注射尼古丁注射液[1 mg/(kg·d),100μL]造模,从妊娠第6天至新生鼠出生后21 d,用动物肺功能分析系统检测各组新生鼠肺功能,根据肺组织重量和体重计算各组新生鼠肺指数,采用HE染色法观察各组新生鼠肺组织形态学变化。结果与S组比较,N组呼气峰值(PEF)、肺动脉顺应性(Cdyn)显著降低(P<0.05),气道阻力(RL)显著增高(P<0.05),肺指数显著降低(P<0.05);新生鼠肺组织中肺泡数明显减少,肺泡体积增大,部分肺泡壁破裂相互融合。与N组比较,N+ST36组PEF、Cydn显著升高(P<0.05),RL显著降低(P<0.05),肺指数显著升高(P<0.05);新生鼠肺组织中肺泡数量增多、肺泡面积减小和肺泡壁破裂融合情况减少。结论电针孕期和哺乳期尼古丁暴露大鼠'足三里'穴可能通过改善新生鼠肺功能、肺指数及肺组织形态学变化发挥对新生鼠肺发育的保护效应。 | 刘翼天 嵇波 苏杭 葛云鹏 王丹 赵国桢 Reiko Sakurai Virender Kumar Rehan | 2018 | 中国医药导报2018，15，7： | 2 |
| 16 | A model to estimate available timber and forest biomass and reforestation expenses in a mountainous region in Japan显示文摘We developed a model to estimate supply potentials and available amounts of timber and forest biomass resources from profitable sub-compartments of thinning and final felling operations. Economic balances were estimated while considering not only harvesting expenses but also reforestation expenses after final felling, which should be considered for sustainable forest management. Harvesting expenses were estimated based on two types of timber harvesting systems and three types of forest biomass harvesting systems in each sub-compartment. Then, the model was applied to Nasushiobara city of Tochigi prefecture, Japan. Reforestation expenses had large negative impacts on the financial balances of final felling operations. Few sub-compartments were profitable after considering reforestation expenses. Most profitable sub-compartments were those with mechanized operation systems and landing sales. These accounted for 17.19% of all sub-compartments, while only 5.75% of the sub-compartments were profitable based on their current operation systems and landing sales. Although the overall supply potentials of timber and forest biomass resources were 380,000 m3 and 210,000 Mg, respectively, and 15 times the planned harvest of coniferous tree volume of 25,000 m3year-1 and 50 times the annual demand for the woody gasification power generation of 4,000 Mg year-1 in Nasushiobara, available amounts of timber and forest biomass resources were only49,429 m3 and 33,333 Mg, which were 13.0% and 15.7% of supply potentials for landing sales with mechanized operation systems. | Kazuhiro Aruga Ayami Murakami Chikara Nakahata Reiko Yamaguchi Masashi Saito Kanae Kanetsuki | 2013 | Journal of Forestry Research2013，24，2： | 2 |
| 17 | 电针对孕期饮食限制诱发宫内生长受限大鼠肺发育不良的影响显示文摘目的:探讨电针母鼠'足三里'穴对孕期饮食限制诱发宫内生长受限(IUGR)子代大鼠肺发育不良的保护效应。方法:将24只雌性SD大鼠随机分为对照组、对照电针组、模型组和模型电针组,每组6只。模型组和模型电针组大鼠从妊娠第10天至分娩期间,给予母鼠50%的饮食限制制备IUGR动物模型。对照电针组和模型电针组妊娠第10天至分娩期间,采用电针母鼠双侧'足三里'穴进行治疗,每日1次。在子代大鼠出生时测量其体质量,并在子代大鼠出生后第21天,测量其体质量和肺质量,采用小动物肺功能检测系统测定其肺功能;HE染色法观察肺组织形态;ELISA法检测肺组织中过氧化物酶体增殖物激活受体γ(PPARγ)含量。结果:与对照组比较,模型组子代大鼠出生时体质量及出生后第21天体质量、肺质量、肺动态顺应性(Cdyn)和PPARγ含量均降低(P<0.01),吸气峰值流速(PIF)值和吸气阻力(RI)值升高(P<0.01),肺泡数量减少,肺泡面积和肺泡间隔厚度增大,部分肺泡出现破裂、融合现象;与模型组比较,模型电针组子代大鼠出生时体质量及出生后第21天体质量、肺质量、Cdyn和PPARγ含量均升高(P<0.01,P<0.05),PIF值和RI值降低(P<0.05),肺泡数量增多,肺泡面积和肺泡间隔厚度减小,肺泡破裂、融合程度有所改善。结论:电针母鼠'足三里'穴可能通过调控肺组织中PPARγ含量,防护饮食限制诱发的IUGR大鼠肺功能和肺组织形态学改变。 | 牟秋杰 嵇波 赵国桢 刘翼天 戴健 路雅雯 Reiko Sakurai Virender Kumar Rehan 谢亚娜 张琴 石天宇 | 2021 | 中国针灸2021，41，4： | 2 |
| 18 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 19 | 电针对围产期尼古丁暴露新生鼠肺功能及肺形态的影响显示文摘目的:通过比较电针孕期及哺乳期尼古丁暴露母鼠'足三里'和'尺泽'穴对新生鼠肺功能和肺形态影响的差异,探讨能改善围产期尼古丁暴露引发新生鼠肺发育变化的特异效应穴位。方法:将24只雌性孕期SD大鼠随机分为正常组、模型组、足三里组、尺泽组,每组6只。自孕期第6天起,正常组皮下注射0.9%氯化钠溶液,余组均皮下注射尼古丁至产后第21天(生产当天不注射)制备孕期及哺乳期尼古丁暴露模型。采用每日2Hz/15Hz、1mA电针母鼠双侧'足三里'穴或'尺泽'穴治疗,与造模同时进行。实验结束后采用小动物肺功能测定仪测定子代鼠肺功能,HE染色法光镜下观测子代鼠肺泡化程度。结果:与正常组相比较,模型组吸气峰值流速(PIF)值、肺总阻力(RL)值和呼气相气道阻力(RE)值均显著升高(P<0.01),呼气峰值流速(PEF)值和肺动态顺应性(Cdyn)值均显著降低(P<0.01),模型组子代鼠肺泡数量减少,肺泡变形破裂融合,肺泡直径显著增加(P<0.01)。与模型组比较,足三里组PIF值、RL值和RE值均显著降低(P<0.01),PEF值和Cdyn值均显著升高(P<0.01,P<0.05),且肺泡数量明显增多,肺泡破裂现象改善,肺泡直径显著降低(P<0.01);尺泽组PIF值显著降低(P<0.01),RL值和RE值均明显降低(P<0.05),PEF值和Cdyn值有升高趋势,但差异无统计学意义(P>0.05),尺泽组肺泡数量明显增多,肺泡破裂现象改善,肺泡直径有减小趋势,但差异无统计学意义(P>0.05)。结论:电针'足三里'和电针'尺泽'均能通过改善孕期及哺乳期尼古丁暴露新生鼠肺功能及肺形态,防护子代鼠肺发育不良,且电针'足三里'穴效果优于电针'尺泽'穴。 | 葛云鹏 嵇波 赵国桢 刘翼天 苏杭 戴健 路雅雯 王丹 Reiko Sakurai Virender Kumar Rehan 严明娜 孙晓敏 白红新 郭孟玮 任晓暄 | 2019 | 针刺研究2019，44，2： | 2 |
| 20 | Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report显示文摘A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens. | Hiromi Tamura Hirotsugu Saiki Takahiro Amano Masashi Yamamoto Shiro Hayashi Hiroka Ando Reiko Doi Tsutomu Nishida Katsumi Yamamoto Shiro Adachi | 2017 | World Journal of Gastroenterology2017，23，21： | 2 |
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