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| 1 | Multipurpose use of the over-the-scope-clip system(“Bear claw”) in the gastrointestinal tract:Swiss experience in a tertiary center显示文摘AIM:To evaluate the outcome of over-the-scope-clip system(OTSC)for endoscopic treatment of various indications in daily clinical practice in Switzerland.METHODS:This prospective,consecutive case series was conducted at a tertiary care hospital from September 2010 to January 2014.Indications for OTSC application were fistulae,anastomotic leakage,perforation,unroofed submucosal lesion for biopsy,refractory bleeding,and stent fixation in the gastrointestinal(GI)tract.Primary technical success was defined as the adequate deployment of the OTSC on the target lesion.Clinical success was defined as resolution of the problem;for instance,no requirement for surgery or further endoscopic intervention.In cases of recurrence,retreatment of a lesion with a second intervention was possible.Complications were classified into those related to sedation,endoscopy,or deployment of the clip.RESULTS:A total of 28 OTSC system applications werecarried out in 21 patients[median age 64 years(range42-85),33%females].The main indications were fistulae(52%),mostly after percutaneous endoscopic gastrostomy tube removal,and anastomotic leakage after GI surgery(29%).Further indications were unroofed submucosal lesions after biopsy,upper gastrointestinal bleeding,or esophageal stent fixation.The OTSC treatments were applied either in the upper(48%)or lower(52%)GI tract.The mean lesion size was 8 mm(range:2-20 mm).Primary technical success and clinical success rates were 85%and 67%,respectively.In53%of cases,the suction method was used without accessories(e.g.,twin grasper or tissue anchor).No endoscopy-related or OTSC-related complications were observed.CONCLUSION:OTSC is a useful tool for endoscopic closure of various GI lesions,including fistulae and leakages.Future randomized prospective multicenter trials are warranted. | Michael Christian Sulz Reto Bertolini Remus Frei Gian-Marco Semadeni Jan Borovicka Christa Meyenberger | 2014 | World Journal of Gastroenterology2014，20，43： | 17 |
| 2 | On brain activity mapping: Insights and lessons from Brain Decoding Project to map memory patterns in the hippocampus显示文摘The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research. | TSIEN Joe Z. LI Meng OSAN Remus CHEN GuiFen LIN LongNian WANG Phillip Lei FREY Sabine FREY Julietta ZHU DaJiang LIU TianMing ZHAO Fang KUANG Hui | 2013 | Science China(Life Sciences)2013，56，9： | 1 |
| 3 | Routine use of Hemospray for gastrointestinal bleeding: prospective two-center experience in Switzerland显示文摘 | Michael Sulz Remus Frei Christa Meyenberger Peter Bauerfeind Gian-Marco Semadeni Christoph Gubler | 2014 | Endoscopy2014，，： | 1 |
| 4 | Routine use of Hemospray for gastrointestinal bleeding: prospective two-center experience in Switzerland显示文摘 | Michael Sulz Remus Frei Christa Meyenberger Peter Bauerfeind Gian-Marco Semadeni Christoph Gubler | 2014 | Endoscopy2014，，： | 1 |
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