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| 1 | Multipurpose use of the over-the-scope-clip system(“Bear claw”) in the gastrointestinal tract:Swiss experience in a tertiary center显示文摘AIM:To evaluate the outcome of over-the-scope-clip system(OTSC)for endoscopic treatment of various indications in daily clinical practice in Switzerland.METHODS:This prospective,consecutive case series was conducted at a tertiary care hospital from September 2010 to January 2014.Indications for OTSC application were fistulae,anastomotic leakage,perforation,unroofed submucosal lesion for biopsy,refractory bleeding,and stent fixation in the gastrointestinal(GI)tract.Primary technical success was defined as the adequate deployment of the OTSC on the target lesion.Clinical success was defined as resolution of the problem;for instance,no requirement for surgery or further endoscopic intervention.In cases of recurrence,retreatment of a lesion with a second intervention was possible.Complications were classified into those related to sedation,endoscopy,or deployment of the clip.RESULTS:A total of 28 OTSC system applications werecarried out in 21 patients[median age 64 years(range42-85),33%females].The main indications were fistulae(52%),mostly after percutaneous endoscopic gastrostomy tube removal,and anastomotic leakage after GI surgery(29%).Further indications were unroofed submucosal lesions after biopsy,upper gastrointestinal bleeding,or esophageal stent fixation.The OTSC treatments were applied either in the upper(48%)or lower(52%)GI tract.The mean lesion size was 8 mm(range:2-20 mm).Primary technical success and clinical success rates were 85%and 67%,respectively.In53%of cases,the suction method was used without accessories(e.g.,twin grasper or tissue anchor).No endoscopy-related or OTSC-related complications were observed.CONCLUSION:OTSC is a useful tool for endoscopic closure of various GI lesions,including fistulae and leakages.Future randomized prospective multicenter trials are warranted. | Michael Christian Sulz Reto Bertolini Remus Frei Gian-Marco Semadeni Jan Borovicka Christa Meyenberger | 2014 | World Journal of Gastroenterology2014，20，43： | 17 |
| 2 | First report of colonoscopic closure of a gastrocolocutaneous PEG migration with over-the-scope-clip-system显示文摘Percutaneous endoscopic gastrostomy(PEG) is a common practice for long-term nutrition of patients who are unable to take oral food. We report of an 85-year old man with a history of recurrent larynx carcinoma and hemicolectomy many years ago due to unknown reason. Laryngectomy was indicated. Preoperatively a PEG was inserted endoscopically after an abdominal ultrasonography without abnormal findings. Few months after PEG insertion, the patient was evaluated for diarrhea and insufficient feeding without signs of infection or peritonism. An upper endoscopy and computed tomography scan confirmed a buried bumper syndrome with migration of the PEG tube into the colon as a rare complication. He underwent successful colonoscopic removal of the internal bumper and closure of the colonic orifice of the fistula with the over-the-scope-clip system(OTSC). OTSC is an endoscopic device for treatment of bleeding, perforation, leak and fistula in the gastrointestinal tract. To the best of our knowledge, this is the first report of the use of OTSC for colonoscopic closure of a gastrocolocutaneous fistula due to a buried bumper syndrome with transcolonic PEG tube migration. | Reto Bertolini Christa Meyenberger Michael Christian Sulz | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 3 | Endoscopic dilation of complete oesophageal obstructionswith a combined antegrade-retrograde rendezvoustechnique显示文摘AIM: To investigate the combined antegraderetrograde endoscopic rendezvous technique for complete oesophageal obstruction and the swallowing outcome.METHODS: This single-centre case series includes consecutive patients who were unable to swallow due to complete oesophageal obstruction and underwent combined antegrade-retrograde endoscopic dilation(CARD) within the last 10 years. The patients' demographic characteristics, clinical parameters, endoscopic therapy, adverse events, and outcomes were obtained retrospectively. Technical success was defined as effective restoration of oesophageal patency. Swallowing success was defined as either percutaneous endoscopic gastrostomy(PEG)-tube independency and/or relevant improvement of oral food intake, as assessed by the functional oral intake scale(FOIS)(≥ level 3).RESULTS: The cohort consisted of six patients [five males; mean age 71 years(range, 54-74)]. All but one patient had undergone radiotherapy for head and neck or oesophageal cancer. Technical success was achieved in five out of six patients. After discharge, repeated dilations were performed in all five patients. During follow-up(median 27 mo, range, 2-115), three patients remained PEG-tube dependent. Three of four patients achieved relevant improvement of swallowing(two patients: FOIS 6, one patient: FOIS 7). One patient developed mediastinal emphysema following CARD, without a need for surgery.CONCLUSION: The CARD technique is safe and a viable alternative to high-risk blind antegrade dilation in patients with complete proximal oesophageal obstruction. Although only half of the patients remained PEG-tube independent, the majority improved their ability to swallow. | Reto Bertolini Christa Meyenberger Paul Martin Putora Franziska Albrecht Martina Anja Broglie Sandro J Stoeckli Michael Christian Sulz | 2016 | World Journal of Gastroenterology2016，22，7： | 3 |
| 4 | Autoimmune hepatitis显示文摘 | Sulz MC Gerlach TJ | 2011 | Ther Umsch2011，68，4： | 1 |
| 5 | The expression of alpha (v) and beta3 integrin subunits in the normal human Fallopian tube epithelium suggests the occurrence of a tubal implantation window 显示文摘 | Sulz L Valenzuela JP Salvatierra AM | 1998 | Hum Reprod1998，13，10： | 1 |
| 6 | Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase显示文摘 | Bodmer M Sulz M Stadlmann S | 2006 | Digestion2006，74，1： | 1 |
| 7 | Effects of epidemiological factors on the impact of fungus Pleclosporium tabacium on false cleavers (Galium spurium) 显示文摘 | Zhang W M Sulz M Bailek K L | 2002 | Biocontrol Science and Technology2002，12，： | 1 |
| 8 | Routine use of Hemospray for gastrointestinal bleeding: prospective two-center experience in Switzerland显示文摘 | Michael Sulz Remus Frei Christa Meyenberger Peter Bauerfeind Gian-Marco Semadeni Christoph Gubler | 2014 | Endoscopy2014，，： | 1 |
| 9 | Routine use of Hemospray for gastrointestinal bleeding: prospective two- center experience in Switzerland显示文摘 | Sulz MC Frei R Meyenberger C | 2014 | Endoscopy2014，46，7： | 1 |
| 10 | Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase显示文摘 | Sulz M Stadlmann S | 2006 | Digestion2006，74，1： | 1 |
| 11 | Fatal liver failure in an a- dult patient with acute lymphoblastic leukemia following treatment with L-asparaginase 显示文摘 | Bodmer M Sulz M Stadlmann S | 2006 | Digestion2006，74，1： | 1 |
| 12 | Evanescent field sensors based on tantalum pentoxide waveguides-a review 显示文摘 | SCHMITT K OEHSE K SULZ G ~t al | 2008 | Sensors2008，8，： | 1 |
| 13 | Ni,In and Sb implanted Pt and V catalysed thin-film SnO2 gas sensors显示文摘 | Sulz G Kuhner G Reiter H Uptmoor G Schweizer W Low H Lacher M Steiner K | 1993 | Sensors and Actuators B1993，1516，： | 1 |
| 14 | The expression of αvβ3 integrin subunits in the normal human fallopian tube epithelium suggests the occurrence of a tubal implantation window显示文摘 | Sulz L Valenzula J P Salvatierra AM | 1998 | Hum Reprod1998，13，10： | 1 |
| 15 | The expression of alpha (v) and beta - 3 integrin subunits in the normal human fallopian tube epithelium suggests the occurrence of a tubal implantation window显示文摘 | SULZ L VALENZUELA J P SALVATIERRA A M | 1998 | Hum Reprod1998，13，10： | 1 |
| 16 | Routine use of Hemospray for gastrointestinal bleeding: prospective two-center experience in Switzerland显示文摘 | Michael Sulz Remus Frei Christa Meyenberger Peter Bauerfeind Gian-Marco Semadeni Christoph Gubler | 2014 | Endoscopy2014，，： | 1 |
| 17 | Routine use of Hemospray for gastrointestinal bleeding: prospective two-center experience in Switzerland 显示文摘 | Sulz MC Frei R Meyenberger C | 2014 | Endoscopy2014，46，7： | 1 |
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