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| 1 | Preoperative rectosigmoid endoscopic ultrasonography predicts the need for bowel resection in endometriosis显示文摘BACKGROUND Rectosigmoid endometriosis is an underdiagnosed disease responsible for abdominal pain, transit disorders and rectal bleeding. Two surgical approaches,rectosigmoid bowel resection(segmental or patch) or intramuscular layer dissection(shaving), are available.AIM To assess whether the lesion features observed via preoperative rectosigmoid endoscopic ultrasonography(RS-EUS) might predict the need for bowel resection.METHODS This multicentric retrospective study was conducted on patients with rectosigmoid endometriosis who underwent a curative surgical procedure,evaluated by RS-EUS performed by two trained operators, between January 2012 and March 2018. A univariate statistical analysis was performed on nodules' RSEUS features(thickness, width, infiltration of the submucosae, presence of a bump into the digestive lumen and presence of multiple rectosigmoid localizations). A multivariate logistic regression was then performed on the significant results.RESULTS Of the 367 patients, 73 patients with rectosigmoid endometriosis were evaluated by RS-EUS and underwent rectosigmoid surgery. After the univariate analysis was completed, thickness, width and infiltration of the submucosae were identified as potential predictive factors for bowel resection. In a multivariate logistic regression model, only thickness appeared to be a significant [odds ratio(OR) = 1.49, 95% confidence interval(CI): 1.04-2.12, P = 0.028] predictive factor for bowel resection. Receiver operating characteristic analysis performed showed that a thickness over 5.20 mm might be used as cut-off with a sensitivity of 76%, a specificity of 81%, and an area under carve = 0.82. The cut-off values for 100%sensitivity and 100% specificity were 0.90 mm and 10.00 mm, respectively. A trend concerning width to predict the need for resection was also observed(OR1.12, 95%CI: 1.00-1.26, P = 0.054)CONCLUSION The presence of a rectosigmoid nodule of endometriosis greater than 5.20 mm thick on RS-EUS might predict the need for bowel resection. | Victor Desplats René-Louis Vitte Joseph du Cheyron Gilles Roseau Arnaud Fauconnier Frédérick Moryoussef | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
| 2 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 3 | Pain and chronic pancreatitis: A complex interplay of multiple mechanisms显示文摘Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians.Traditional theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial pressures.These observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often unsatisfactory.This underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain generation.Amongst other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain disorders.However,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of pain.This review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic approaches.Furthermore,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment. | Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 4 | Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging显示文摘 | Hanna J?rnum Elena G. Steffensen Linda Knutsson Ernst-Torben Fründ Carsten Wiberg Simonsen S?ren Lundbye-Christensen Ajit Shankaranarayanan David C. Alsop Finn Taageh?j Jensen Elna-Marie Larsson | 2010 | Neuroradiology2010，，4： | 1 |
| 5 | Significance of the signal-to-cutoff ratios of anti-hepatitis C virus enzyme immunoassays in screening of Chinese blood donors显示文摘 | Ren FR Lv QS Zhuang H | 2005 | Transfusion2005，45，11： | 1 |
| 6 | Physiology and pathophysiology of renal aquaporins显示文摘 | Tae-Hwan Kwon Henrik Hager Lene N. Nejsum Marie-Louise E. Andersen J?rgen Fr?ki?r S?ren Nielsen | 2001 | Seminars in Nephrology2001，，3： | 1 |
| 7 | Blood banking in China显示文摘 | Shan H Wang JX Ren FR | | 0，，9347： | 1 |
| 8 | A multi-Chinese blood center study testing serologic-negative donor samples for hepatitis C vi-rus and human immunodeficiency virus with nucleic acid testing显示文摘 | Shan H Ren FR Zhao HY | | 0，，11： | 1 |
| 9 | Expression of fascin in thyroid neoplasms:a novel diagnostic marker显示文摘 | Chen G Zhang FR Ren J | 2008 | J Cancer Res Clin Oncol2008，134，9： | 1 |
| 10 | Significance of the signal- to-cutoff ratios of anti-hepatitis C virus enzyme immunoassays in screening of Chinese blood donors显示文摘 | Ren FR Lv QS Zhuang H | 2005 | Transfusion2005，45，11： | 1 |
| 11 | Opioid-Induced Bowel Dysfunction显示文摘 | Christina Brock S?ren Schou Olesen Anne Estrup Olesen Jens Br?ndum Fr?kjaer Trine Andresen Asbj?rn Mohr Drewes | 2012 | Drugs2012，，14： | 1 |
| 12 | Significance of the signal-to-cutoff ratios of anti-hepatitis C virus enzyme immunoassays in screening of Chinese blood donors显示文摘 | Ren FR Lv QS Zhuang H | 2005 | Transfusion2005，45，11： | 1 |
| 13 | Expression of fascin in thyroid neoplasms:a novel diagnostic marker显示文摘 | Chen G Zhang FR Ren J | 2008 | J Cancer Res Clin Oncol2008，134，9： | 1 |
| 14 | Treatment-related frequency of venous thrombosis in lower esophageal, gastro-esophageal and gastric cancer – a clinical prospective study of outcome and prognostic factors显示文摘 | Anders Christian Larsen Jens Br?ndum Fr?kj?r Rune Vincents Fisker Victor Iyer Peter Br?ndum Mortensen Mette Karen Yilmaz Bjarne M?ller S?ren Risom Kristensen Ole Thorlacius-Ussing | 2015 | Thrombosis Research2015，，： | 1 |
| 15 | Blood banking in China显示文摘 | Shan H Wang JX Ren FR | 2002 | Lancet2002，360，9347： | 1 |
| 16 | Radical ablative surgery and radial forearm free flap (RFFF) reconstruction for patients with oral or oropharyngeal cancer: postoperative outcomes and oncologic and functional results显示文摘 | Alexandre Bozec Gilles Poissonnet Emmanuel Chamorey Claire Laout Jacques Vallicioni Fran? ois Demard Fré dé ric Peyrade Philippe Follana René -Jean Bensadoun Karen Benezery Juliette Thariat Pierre-Yves Marcy Anne Sudaka Olivier Dassonville | 2009 | Acta Oto-Laryngologica2009，，6： | 1 |
| 17 | A multi-Chinese blood center study testing serologic-negative donor samples for hepatitis C virus and human immunodeficiency virus with nucleic acid testing显示文摘 | Shan H Ren FR Zhao HY | 2007 | Transfusion2007，47，11： | 1 |
| 18 | The biomechanical effect and clinical application of Ni- Ti memory expansion clamp显示文摘 | Mei FR Ren XJ Wang WD | 1997 | Spine1997，，： | 1 |
| 19 | Update of exocrine functional diagnostics in chronic pancreatitis显示文摘 | Camilla N?jgaard S?ren Schou Olesen Jens Br?ndum Fr?kj?r Asbj?rn Mohr Drewes | 2013 | Clin Physiol Funct Imaging2013，，3： | 1 |
| 20 | Evaluation of the performance of the EIAgen HCV test for detection of hepatitis C virus infec- tion 显示文摘 | Rao HY Ren FR Guan WL | 2009 | J Viral Methods2009，162，12： | 1 |
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