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| 1 | Effects of traits,species identity and local environmental conditions on the assessment of interactions:insights from an alpine meadow community显示文摘Aims The prediction that facilitation is the dominant interaction in physically stressful conditions has been supported by many but not all field studies.In the present paper,we tested the effects of the identity of species,the local environmental conditions and the currencies of performance measurement on such variation.Methods Using contrasting two plots,six species,and up to five multiple traits,we comprehensively explored the effects of the above factors on the assessment of plant interactions in an alpine meadow of the QingHai Tibetan Plateau.Additionally,we attempted to figure out the possible mechanisms underlying the responses observed.The data were analysed by both standard ANOVAs and multivariate statistics.Important findings Our results demonstrated that the response to the removal of neighbours was both species and trait specific,and the effect of the ocal environmental conditions was dependent on the species involved.The contrast between plots had crucial influence on the net interactions of Kobresia macrantha,but little effect on Elymus nutans.Regarding the abiotic conditions,neighbours had significant impact on soil temperature,moist and solar radiation.The results contribute to advance our knowledge on the potential underlying factors influencing the assessment of facilitation. | Chengjin Chu Youshi Wang Qi Li Luqiang Zhao Zhengwei Ren Sa Xiao Jianli Yuan Gang Wang | 2009 | Journal of Plant Ecology2009，2，3： | 6 |
| 2 | Variation and heritability of morphological and physiological traits among Leymus chinensis genotypes under different environmental conditions显示文摘Intraspecific trait variation and heritability in different environmental conditions not only suggest a potential for an evolutionary response but also have important ecological consequences at the population, community, and ecosystem levels. However, the contribution of quantitative trait variation within a grassland species to evolutionary responses or ecological consequences is seldom documented. Leymus chinensis is an important dominant species in semi-arid grasslands of China, which has seriously suffered from drought and high temperature stresses in recent decades. In the present study, we measured variation and heritability of 10 quantitative traits, namely the number of tillers, maximum shoot height, number of rhizomes, maximum rhizome length, rhizome mass, aboveground mass, root mass, maximum net photosynthetic rate(Pmax), specific leaf area(SLA), and leaf length to leaf width ratio(LL/LW), for 10 genotypes of L. chinensis under one non-stress(Ck) condition and three environmental stress conditions(i.e., drought(Dr), high temperature(Ht), and both drought and high temperature(DrHt)). Result indicated that(1) the interaction of genotype and environmental condition(G×E) was significant for 6 traits but not significant for the other 4 traits as shown by two-way analysis of variance(ANOVA), suggesting that different selection forces were placed for different traits on the factors dominating phenotypic responses to different environmental conditions. Moreover, these significant G×E effects on traits indicated significantly different phenotypic adaptive responses among L. chinensis genotypes to different environmental conditions. Additionally, individuals could be grouped according to environmental condition rather than genotype as shown by canonical discriminant analysis, indicating that environmental condition played a more important role in affecting phenotypic variation than genotype;(2) by one-way ANOVA, significant differences among L. chinensis genotypes were found in all 10 traits under Ck and Dr conditions, in 8 traits under Dr Ht condition and only in 4 traits under Ht condition; and(3) all 10 traits showed relatively low or non-measurable broad-sense heritability(H_2) under stress conditions. However, the lowest H_2 value for most traits did not occur under DrHt condition, which supported the hypothesis of 'unfavorable conditions have unpredictable effects' rather than 'unfavorable conditions decrease heritability'. Results from our experiment might aid to improve predictions on the potential impacts of climate changes on L. chinensis and eventually species conservation and ecosystem restoration. | YANG Xue LI Junpeng ZHAO Tingting MO Lidong ZHANG Jianli REN Huiqin ZHAO Nianxi GAO Yubao | 2019 | Journal of Arid Land2019，11，1： | 4 |
| 3 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 4 | Effect of ammonium sulfate and urea on PCDD/F formation from active carbon and possible mechanism of inhibition显示文摘The effect of ammonium sulfate((NH4)2SO4) and urea(CO(NH2)2) on polychlorinated dibenzo-p-dioxin and dibenzofuran(PCDD/F) formation from active carbon was investigated in this study. Both additives could significantly inhibit PCDD/F formation, and PCDD/F(TEQ)generation was reduced to 98.5%(98%) or 64.5%(77.2%) after 5%(NH4)2SO4or CO(NH2)2was added into model ash, respectively. The inhibition efficiency of PCDDs was higher than the value of PCDFs, however, the reduction of PCDD/F yield was mainly from PCDFs decreasing. In addition, the solid-phase products were reduced more than the gas-phase compounds by inhibitors. By the measurement of chlorine emission in the phase of ion(Cl[Cl-]) and molecule gas(Cl[Cl2]), it was observed that both Cl[Cl-] and Cl[Cl2] were reduced after inhibitors were added into ash. Cl[Cl2] was reduced to 51.0% by urea addition, which was supposed as one possible mechanism of PCDD/F inhibition. | Mi Yan Zhifu Qi Jie Yang Xiaodong Li Jianli Ren Zhang Xu | 2014 | Journal of Environmental Sciences2014，26，11： | 3 |
| 5 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 6 | Emerging important roles of circRNAs in human cancer and other diseases显示文摘CircRNAs are a large class of endogenous single-stranded RNA that is different from other linear RNA,which are produced by back-splicing and fusion of either exons,introns,or both exon-intron into covalently closed loops.CircRNAs are found in almost all living organisms and have emerged as potentially important players effecting on all life activities.It was char-acterized by stable structure,resistant to RNA degradation,highly abundance and conserva-tion and tissue-specific expression.Early circRNAs were ignored as a by-product of meaningless abnormally cut RNA and had little biological function.Currently,circRNAs have become a research hotspot due to its special characteristics.CircRNAs could function as miRNA sponges,interfere with splicing and bind to protein to regulate the expression of parental genes and so on.In recent years,an increasing number of studies have revealed that circRNAs are closely related to a series of physiological and pathological processes.Additionally,cir-cRNAs play an important role in the occurrence and development of a variety of diseases,sug-gesting circRNAs may be as novel indicators or biomarkers for cancer and other diseases with which they are associated.In this article,we review the biogenesis,biological functions of cir-cRNAs and recent advances in circRNAs research in human diseases.Results will provide new insights on the roles and new ideas of circRNAs for the diagnosis and treatment of diseases and possible directions and approach for future circRNA applications. | Yong Huang Cai Zhang Jianli Xiong Hongtao Ren | 2021 | Genes & Diseases2021，8，4： | 2 |
| 7 | Age and Body Size of the Shangcheng Stout Salamander Pachyhynobius shangchengensis(Caudata:Hynobiidae)from Southeastern China显示文摘Age and body size a re critical for understanding life history evolution and ecology.In this study,the age and body size of the Shangcheng stout salamander,Pachyhynobius shangchengensis,from a population in Anhui Province,China,were studied by skeletochronology.The mean age was 8.8±0.2(mean±SD)years in females and 9.6±0.2 in males and ranged 5-13 years for both sexes.The mean age was significantly different between sexes.The mean body size and mass were(100.21±0.91)mm and(31.76±0.73)g in females,and(105.31±1.23)mm and(37.14±1.12)g in males,respectively.Males were significantly larger and heavier than females,indicating sexual size dimorphism.There was a significant positive correlation among body size,body mass,and age,suggesting that the oldest individuals are larger and heavier.The growth rate in males was significantly higher than in females.The present study provides preliminary data on life-history traits which can be helpful for future studies of this species and other hynobiid salamanders. | Jianli XIONG Jianping GOU Yong HUANG Baowei ZHANG Hongtao REN Tao PAN | 2020 | Asian Herpetological Research2020，11，3： | 2 |
| 8 | MDR1 and MDR3 genes and drug resistance to cisplatin of ovarian cancer cells 显示文摘 | REN Lirong XIAO Lan HU JianLi | 2007 | Journal of Huazhong University of Science and Technology2007，27，6： | 1 |
| 9 | Study of mercury emission during coal combustion显示文摘 | Ren Jianli Zhou Jinsong Luo Zhongyang | 2002 | Journal of Zhejiang University (Engineering Science)2002，36，4： | 1 |
| 10 | Synergistic effects of ultrasound-targeted microbubble destruction and TAT peptide on gene transfecon : an experimental study in vitro and in vivo显示文摘 | Zhiyi Zhou Ping Zhang Jianli Ren | 2013 | Journal of Controlled Release2013，，170： | 1 |
| 11 | Targeting papain-like protease for broad-spectrum coronavirus inhibition显示文摘The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades emphasize the need for next-generation pan-coronaviral therapeutics.Drugging the multi-functional papain-like protease(PLpro)domain of the viral nsp3 holds promise.However,none of the known coronavirus PLpro inhibitors has been shown to be in vivo active.Herein,we screened a structurally diverse library of 50,080 compounds for potential coronavirus PLpro inhibitors and identified a noncovalent lead inhibitor F0213 that has broad-spectrum anti-coronaviral activity,including against the Sarbecoviruses(SARSCoV-1 and SARS-CoV-2),Merbecovirus(MERS-CoV),as well as the Alphacoronavirus(hCoV-229E and hCoVOC43).Importantly,F0213 confers protection in both SARS-CoV-2-infected hamsters and MERS-CoV-infected human DPP4-knockin mice.F0213 possesses a dual therapeutic functionality that suppresses coronavirus replication via blocking viral polyprotein cleavage,as well as promoting antiviral immunity by antagonizing the PLpro deubiquitinase activity.Despite the significant difference of substrate recognition,mode of inhibition studies suggest that F0213 is a competitive inhibitor against SARS2-PLpro via binding with the 157K amino acid residue,whereas an allosteric inhibitor of MERSPLpro interacting with its 271E position.Our proof-ofconcept findings demonstrated that PLpro is a valid target for the development of broad-spectrum anticoronavirus agents.The orally administered F0213 may serve as a promising lead compound for combating the ongoing COVID-19 pandemic and future coronavirus outbreaks. | Shuofeng Yuan Xiaopan Gao Kaiming Tang Jian-Piao Cai Menglong Hu Peng Luo Lei Wen Zi-Wei Ye Cuiting Luo Jessica Oi-Ling Tsang Chris Chun-Yiu Chan Yaoqiang Huang Jianli Cao Ronghui Liang Zhenzhi Qin Bo Qin Feifei Yin Hin Chu Dong-Yan Jin Ren Sun Jasper Fuk-Woo Chan Sheng Cui Kwok-Yung Yuen | 2022 | Protein & Cell2022，13，12： | 0 |
| 12 | 2-25 Interpretation on the Mass Dependent Behavior of Transverse Flow Using Collective-thermal Competition (Percolation) Model显示文摘According to the interplay model proposed in Ref. [1], an improved model, Collective-thermal Competition(Percolation) Model (CTCPM) is developed. The improvements are made by adding the momentum conservationinto the interplay of the thermal motion and the collective motion and limiting the emitting system to be finite.For a nuclear system at a thermal equilibrium, the momentum of the thermal motion distributes isotropically in x,y, z directions (z is the beam direction) and make no effect on the flow (Px) in average. | Liu Xingquan Wada Roy Chen Zhiqiang Huang Meirong Lin Weiping Ren Peipei Zhang Suyalatu Jin Zengxue Jia Baolu Han Rui Liu Jianli Shi Fudong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 13 | 2-26 Effect on Transverse Flow Definition from Different Reaction Mechanisms in AMD and CoMD — Semi-transparency显示文摘In general, the definition of the transverse flow can be classified into the slope flow[1] and the average flow[2]in the certain mid-rapidity region. For a given type of isotope with mass number A, these two definitions are,respectively, expressed | Liu Xingquan Wada Roy Chen Zhiqiang Huang Meirong Lin Weiping Ren Peipei Zhang Suyalatu Jin Zengxue Jia Baolu Han Rui Liu Jianli Shi Fudong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 14 | 2-33 Measurement of Leakage Neutron Spectra for Tungsten with D-T Neutrons and Validation of Evaluated Nuclear Data显示文摘China has started to develop the Chinese Initiative Accelerator Driven Systems (C-ADS) project which is nowunderway vigorously. This project mainly aims at high radioactive nuclear waste transmutation, fuel breeding andclean energy production. In the design of C-ADS, 1 GeV high intensity proton beam bombards on heavy metalspallation target inside the subcritical reactor, and provides external neutron source for the subcritical reactor. Thecombination of evaluated nuclear data with a Monte Carlo transportation code like MCNP is widely utilized fordesigning such kind of nuclear engineering facilities. However, the transportation codes and evaluated nuclear dataused need to be validated through integral experiments[1?5]. | Zhang Suyalatu Chen Zhiqiang Han Rui Liu Xingquan Lin Weiping Ren Peipei Tian Guoyu Luo Fei Liu Jianli Shi Fudong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 15 | 2-34 Neutron Time-of-Flight Spectrometer Based on HIRFL for Studies of Spallation Reactions Related to ADS Project显示文摘The combination of nuclear models with a Monte Carlo transportation code like MCNP, GEANT4 and FLUKA,nucleon meson transport codes (NMTC) are widely utilized for designing of Accelerator Driven Systems (ADS).However, the nuclear models embedded into transportation codes need to be validated by experimental measure-ments. A Neutron Time-of-Flight (NTOF) spectrometer, which is based on Heavy Ion Research Facility in Lanzhou(HIRFL), is designed for further investigations of reaction mechanisms and neutron productions of proton inducedspallation reactions related to the ADS project. The NTOF spectrometer is capable of measuring neutrons in awide energy and angular ranges. It consists of a beam pick-up detector and 10 individual neutron detection modules.The schematic view of the NTOF spectrometer is shown in Fig. 1. | Zhang Suyalatu Chen Zhiqiang Liu Jianli Shi Fudong Han Rui Liu Xingquan Lin Weiping Ren Peipei Tian Guopu Luo Fei | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 16 | 2-35 Investigation of Neutron Induced Reactions on Gallium Sample by Using Talys1.6显示文摘We investigate the neutron induced reactions on gallium sample, and its experimental neutron leakage spectra at the neutron incident energy of 14.8 MeV are comparedwith the Talys1.6[1] calculated results at 60? and120?. In the Talys code, the neutron-induced reactionis divided in three physical processes, e.g., direct, preequilibriumand compound nucleus reactions. Calculatedtotal neutron leakage energy spectrum and thecontributions from three processes are shown in Fig. 1(a). Natural Ga (60.11% 69Ga and 39.89% 71Ga) sampleswere used in the plots. The calculated total crosssection shows three characteristic features, an elasticpeak, an inelastic peak and a broad bump in the lowenergy side. The elastic and inelastic peaks are generatedby the direct process. The broad bump at thelow energy is dominated by the compound nucleus process. | Han Rui Chen Zhiqiang Zhang Suyalatu Liu Jianli Shi Fudong Liu Xingquan Lin Weiping Ren Peipei Tian Guoyu Luo Fei | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 17 | Highly Anisotropic Magnetism and Nearly Isotropic Magnetocaloric Effect in Mn_(3)Sn_(2)Single Crystals显示文摘Mn_(3)Sn_(2)has been proposed as an ideal material for magnetic refrigeration.It undergoes two successive ferromagnetic transitions(T_(C1)=262 K and T_(C2)=227 K)and one antiferromagnetic transition(TN=192 K).Herein we report,for the first time,the preparation of single crystals of Mn_(3)Sn_(2)from Bi flux.The resultant anisotropic magnetic properties and magnetocaloric effect are investigated along the three principal crystallographic directions of the crystal.Significant anisotropy of magnetic susceptibility and multiple field-induced metamagnetic transitions were found at low fields,whereas the magnetocaloric effect was found to be almost isotropic and larger than that of the polycrystalline one.The maximum magnetic entropy change amounts to-ΔSM=4.01 J·kg^(-1)·K^(-1)near T_(C1)under a magnetic field change of μ_(0)ΔH=5 T along the c-axis,with the corresponding refrigerant capacity of 1750 mJ·cm^(-3).Combined with a much wider cooling temperature span(~80 K),our results demonstrate Mn_(3)Sn_(2)single crystal to be an attractive candidate working material for active magnetic refrigeration at low temperatures. | Jianli Bai Qingxin Dong Libo Zhang Qiaoyu Liu Jingwen Cheng Pinyu Liu Cundong Li Yingrui Sun Yu Huang Zhian Ren Genfu Chen | 2023 | Chinese Physics Letters2023，40，12： | 0 |
| 18 | 2- 27 Primary Fragments Reconstruction显示文摘 | Lin Weiping Liu Xingquan Zhang Suyalatu Huang Meirong Liu Jianli Shi Fudong Han Rui Jin Zengxue Ren Peipei Jia Baolu Zhao Minghui Chen Zhiqiang R. Wada | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 19 | 2 - 29 Secondary Decay Effect on n/p and t/aHe Ratio in 64Ni+58Ni Reaction at 40 AMeV显示文摘 | Lin Weiping Liu Xingquang Huang Meirong Zhang Suyalatu Hart Rui Liu Jianli Shi Fudong Jin Zengxue Ren Peipei Jia Baolu Chen Zhiqiang Roy Wada | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 20 | 2- 30 Isotope Yields Ratio Temperatures显示文摘 | Lin Weiping Liu Xingquang Huang Meirong Zhang Suyalatu Han Rui Liu Jianli Shi Fudong Jin Zengxue Ren Peipei Jia Baolu Chen Zhiqiang Roy Wada | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
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