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| 1 | NF-κB and STAT3 signaling pathways collaboratively link infl ammation to cancer显示文摘Although links between cancer and inflammation were fi rstly proposed in the nineteenth century,the molecular mechanism has not yet been clearly understood.Epidemiological studies have identified chronic infections and infl ammation as major risk factors for various types of cancer.NF-κB transcription factors and the signaling pathways are central coordinators in innate and adaptive immune responses.STAT3 regulates the expression of a variety of genes in response to cellular stimuli,and thus plays a key role in cell growth and apoptosis.Recently,roles of NF-κB and STAT3 in colon,gastric and liver cancers have been extensively investigated.The activation and interaction between STAT3 and NF-κB play vital roles in control of the communication between cancer cells and infl ammatory cells.NF-κB and STAT3 are two major factors controlling the ability of pre-neoplastic and malignant cells to resist apoptosis-based tumor-surveillance and regulating tumor angiogenesis and invasiveness.Understanding the molecular mechanisms of NF-κB and STAT3 cooperation in cancer will offer opportunities for the design of new chemo-preventive and chemotherapeutic approaches. | Yihui Fan Renfang Mao Jianhua Yang | 2013 | Protein & Cell2013，4，3： | 52 |
| 2 | Multi-objective optimization of a mixed-flow pump impeller using modified NSGA-II algorithm显示文摘In order to maintain a uniform distribution of pareto-front solutions, a modified NSGA-II algorithm coupled with a dynamic crowding distance(DCD) method is proposed for the multi-objective optimization of a mixed-flow pump impeller. With the pump meridional section fixed, ten variables along the shroud and hub are selected to control the blade load by using a three-dimensional inverse design method. Hydraulic efficiency, along with impeller head, is applied as an optimization objective; and a radial basis neural network(RBNN) is adopted to approximate the objective function with 82 training samples. Local sensitivity analysis shows that decision variables have different impacts on the optimization objectives. Instead of randomly selecting one solution to implement, a technique for ordering preferences by similarity to ideal solution(TOPSIS) is introduced to select the best compromise solution(BCS) from pareto-front sets. The proposed method is applied to optimize the baseline model, i.e. a mixed- flow waterjet pump whose specific speed is 508 min?1?m3s?1?m. The performance of the waterjet pump was experimentally tested. Compared with the baseline model, the optimized impeller has a better hydraulic efficiency of 92% as well as a higher impeller head at the design operation point. Furthermore, the off-design performance is improved with a wider highefficiency operation range. After optimization, velocity gradients on the suction surface are smoother and flow separations are eliminated at the blade inlet part. Thus, the authors believe the proposed method is helpful for optimizing the mixed-flow pumps. | HUANG RenFang LUO XianWu JI Bin WANG Peng YU An ZHAI ZhiHong ZHOU JiaJian | 2015 | Science China(Technological Sciences)2015，58，12： | 32 |
| 3 | Cavitation shedding dynamics around a hydrofoil simulated using a filter-based density corrected model显示文摘The unsteady turbulent cloud cavitation around a NACA66 hydrofoil was simulated using the filter-based density corrected model(FBDCM). The cloud cavitation was treated as a homogeneous liquid-vapor mixture and the effects of turbulent eddy viscosity were reduced in cavitation regions near the hydrofoil and in the wake. The numerical results(in terms of the vapor shedding structure and transient pressure pulsation due to cavitation evolution) agree well with the available experimental data, showing the validity of the FBDCM method. Furthermore, the interaction of vortex and cavitation was analyzed based on the vorticity transport equation, revealing that the cavitation evolution has a strong connection with vortex dynamics. A detailed analysis shows that the cavitation could promote the vortex production and flow unsteadiness by the dilatation and baroclinic torque terms in the vorticity transport equation. | YU An JI Bin HUANG RenFang ZHANG Yao ZHANG YuNing LUO XianWu | 2015 | Science China(Technological Sciences)2015，58，5： | 8 |
| 4 | Unstable flow characteristics in a pump-turbine simulated by a modified Partially-Averaged Navier-Stokes method显示文摘Positive slope characteristics are very important for the safe and stable operation of a pump-turbine. In this study, the unsteady flows in a pump-turbine at pump mode are investigated numerically. To predict the positive slope characteristics with an improved accuracy, a modified Partially-Averaged Navier-Stokes(MPANS) model is employed to capture the unstable physics in a pump-turbine. It is confirmed that the present numerical method predicts the positive slope characteristics in the pumpturbine fairly well compared with the experimental data. It is noted that at the drooping point of the performance curve(positive slope), there are three sets of rotating stall cells in the flow passages of both the guide vanes and stay vanes. In the guide vane region, the flow is completely shut off by the rotating stall, whereas in the stay vane region, the flow passage is partly blocked at the drooping point. The numerical results also reveal that the remarkable variation and high angle of attack(AOA) values upstream the leading edge of the guide vane contribute to the flow separation at the vane suction side and induce rotating stall in the flow passage within the positive slope region. Furthermore, the propagation of the rotating stall is depicted by both Eulerian and Lagrangian viewpoints: the rotating stall blocks the flow passage between two neighboring guide vanes and pushes the flow toward the leading edge of the subsequent guide vane. The rotating stall cell shifts along the rotational direction with a much lower frequency(0.146 f_n) compared with the runner rotational frequency, f_n. | YANG Dandan LUO XianWu LIU DeMin HUANG RenFang ZHU ZuChao | 2019 | Science China(Technological Sciences)2019，62，3： | 7 |
| 5 | Leaching of Nutrient Elements in a Red Soil Derived from Quaternary Red Clay显示文摘A red soil derived from Quaternary red clay was employed to study nutrient leaching with soil columns repacked in laboratory. The objective was to identify the effects of fertilization practices on leaching patterns and magnitudes of Ca2+, Mg2+, K+, NH+, and NO-. The treatments were CK (as a control), CaCO3,CaSO4, MgCO3, Ca(H2PO4)2, urea, KCI, and multiple (a mixture of the above-mentioned fertilizers). The fertilizers were added to the bare surface of the soil columns, and then the columns were leached with 120 mL deionized water daily through peristaltic pumps over a period of 92 days. Leaching processes of NH+, and NO- were only measured in CK, urea, and multiple treatments which were directly related to N leaching.Results showed that sole application of CaSO4, and Ca(H2PO4)2 scarcely had any effect on the leaching losses of Ca2+, Mg2+, and K+; the application of MgCO3 stimulated the leaching of Mg2+; the application of CaCOs promoted the leaching of Ca2+, Mg2+ and K+; urea treatment also promoted the leaching of K+ and NH+, and NO- leaching mainly occurred at late stage of leaching process in particular; under KCI treatment, leaching of Ca2+, Mg2+, and K+ was promoted to a large extent; under multiple treatment,leaching of Ca2+, Mg2+, K+, NH+, and NO- was all increased and NO- was mainly leached at the end of leaching process and still had a trend of increase. | SHEN RENFANG and ZHAO QIGUO(Laboratory Of Material Cycling in Pedosphere, Institute of Soil Science, the Chinese Academy of Sciences,P.O. Box 821, Nanjing 210008 (China)) | 1998 | Pedosphere1998，8，1： | 5 |
| 6 | The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation显示文摘The immune checkpoint blockade(ICB)targeting on PD-1/PD-L1 has shown remarkable promise in treating cancers.However,the low response rate and frequently observed severe side effects limit its broad benefits.It is partially due to less understanding of the biological regulation of PD-L1.Here,we systematically and comprehensively summarized the regulation of PD-L1 from nuclear chromatin reorganization to extracellular presentation.In PD-L1 and PD-L2 highly expressed cancer cells,a new TAD(topologically associating domain)(chr9:5,400,000-5,600,000)around CD274 and CD273 was discovered,which includes a reported super-enhancer to drive synchronous transcription of PD-L1 and PD-L2.The re-shaped TAD allows transcription factors such as STAT3 and IRF1 recruit to PD-L1 locus in order to guide the expression of PD-L1.After transcription,the PD-L1 is tightly regulated by mi RNAs and RNA-binding proteins via the long 3’UTR.At translational level,PD-L1 protein and its membrane presentation are tightly regulated by post-translational modification such as glycosylation and ubiquitination.In addition,PD-L1 can be secreted via exosome to systematically inhibit immune response.Therefore,fully dissecting the regulation of PD-L1/PD-L2 and thoroughly detecting PD-L1/PD-L2 as well as their regulatory networks will bring more insights in ICB and ICB-based combinational therapy. | Zhiwei Fan Changyue Wu Miaomiao Chen Yongying Jiang Yuanyuan Wu Renfang Mao Yihui Fan | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 7 | Regnase-1, a rapid response ribonuclease regulating nflammation and stress responses显示文摘 | Renfang Mao Riyun Yang Xia Chen Edward W Harhaj Xiaoying Wang Yihui Fan | 2017 | Cellular & Molecular Immunology2017，14，5： | 3 |
| 8 | Direct numerical simulation of low Reynolds number turbulent air-water transport in fuel cell flow channel显示文摘With performance improvement of low-temperature fuel cell(FC), high reactant supply and water generation rates may induce air-water turbulence in the FC flow channel. In this research, an air-water turbulent direct numerical simulation(DNS) model is developed to simulate different droplet sizes,locations and interactions in the air-water transport processes comprehensively. It is found that a larger droplet breaks up more easily in turbulence, and a smaller droplet tends to keep lumped. The droplet at corner does not break up because it is away from channel center. The droplet interaction simulations show that the small droplets merge to form slugs, but still keep lumped in turbulence. It is suggested that two conditions need to be satisfied for droplet break up in FC flow channel, one is turbulent flow, and another is that the droplet needs to be large enough and occupy the center region of flow channel to suffer sufficient turbulence fluctuations. The DNS results illustrate some unique phenomena in turbulent flow, and show that the turbulence has significant effect on the air-water flow behavior in FC flow channel. | Zhiqiang Niu Renfang Wang Kui Jiao Qing Du Yan Yin | 2017 | Science Bulletin2017，62，1： | 3 |
| 9 | Evaluation of Epstein-Barr Virus Salivary Shedding in HIV/AIDS Patients and HAART Use: A Retrospective Cohort Study显示文摘Little data is available on the evaluation of the occurrence rates of Epstein-Barr virus(EBV) in saliva and relationship with highly active antiretroviral therapy(HAART) use in HIV/AIDS patients in China. We conducted a retrospective cohort study of EBV serological tests for HIV/AIDS patients who were treated in the hospitals for infectious diseases in Wuxi and Shanghai, China from May 2016 to April 2017. The EBV-seropositive samples were identified by ELISA. EBV-specific primers and probes were used for the quantitative detection of viral DNA from saliva via quantitative real-time polymerase chain reaction. CD4 cell counts of the HIV/AIDS patients were detected by a flow cytometry. A total of 372 HIV/AIDS patients were ultimately selected and categorized for this retrospective cohort study. For EBV IgG and IgM, the HIV/AIDS HAART use(H) and non-HAART use(NH) groups had significantly higher seropositive rates than the HIV-negative control group. The HIV/AIDS(NH) group had the highest seropositive rate(IgG, 94.27%; IgM, 68.98%) and the highest incidence of EBV reactivation or infection. For salivary EBV DNA-positive rates and quantities, the HIV/AIDS(H)(73.69%) and the HIV/AIDS(NH)(100%) groups showed significantly higher values than the HIV-negative control group(35.79%,[ twofold). Further, the salivary EBV DNA-negative population had significantly higher CD4 cell counts than the EBV DNA-positive population in the HIV/AIDS(H) group and the HIV/AIDS(NH) groups. Thus, HAART use is beneficial in decreasing the EBV salivary shedding in HIV/AIDS patients and indirectly decreases EBV transmission risk. | Yan Yan Yong Ren Renfang Chen Jing Hu Yongjia Ji Junyang Yang Jiayin Shen Lvyin Hu Hao Pei Jun Wang Yuanwang Qiu Hongzhou Lu Lihua Huang | 2018 | Virologica Sinica2018，33，3： | 3 |
| 10 | Failure mode investigation of fuel cell for vehicle application显示文摘 | Zhongjun HOU Renfang WANG Keyong WANG Weiyu SHI Danming XING Hongchun JIANG | 2017 | Frontiers in Energy2017，11，3： | 2 |
| 11 | Elucidating the operating behavior of PEM fuel cell with nickel foam as cathode flow field显示文摘Metal foam material,which serves as an alternative replacement of the conventional flow distributor of proton exchange membrane(PEM)fuel cell,has been attracting much attention over last few decades.In this work,three-dimensional modeling work for PEM fuel cell containing metal foam as cathode flow distributor has been carried out.The fuel cell performance and operating characteristics of metal foam flow field and conventional parallel flow channel have been compared and discussed.The cell performance has been reasonably validated based on the corresponding experimental tests conducted in this study.The superior performance of PEM fuel cell with metal foam as cathode flow field benefits a lot from the uniform gas flow.The porous metal foam material provides more pathways for the water delivery at the interface of metal foam flow field and gas diffusion layer(GDL),accelerating water removal capability of cathode.Because of the significant oxygen transfer loss in diffusion limited parallel channel,the operation of PEM fuel cell with parallel channel is found to be more sensitive to cathode humidification and oxygen supply at inlet.Due to the more uniform and effective electron transport though the porous electrode,it is possible to use thinner GDL in metal foam PEM fuel cell.It is expected that this study could give a good baseline of operating behavior of PEM fuel cell with metal foam flow distributor. | HUO Sen SHI WeiYu WANG RenFang LU BingBing WANG Yang JIAO Kui HOU ZhongJun | 2021 | Science China(Technological Sciences)2021，64，5： | 2 |
| 12 | HASN:A Hierarchical Attack Surface Network for System Security Analysis显示文摘Attack surfaces, as one of the security models, can help people to analyse the security of systems in cyberspace, such as risk assessment by utilizing various security metrics or providing a cost-effective network hardening solution. Numerous attack surface models have been proposed in the past decade,but they are not appropriate for describing complex systems with heterogeneous components. To address this limitation, we propose to use a two-layer Hierarchical Attack Surface Network(HASN) that models the data interactions and resource distribution of the system in a component-oriented view. First, we formally define the HASN by extending the entry point and exit point framework. Second, in order to assess data input risk and output risk on the HASN, we propose two behaviour models and two simulation-based risk metrics. Last, we conduct experiments for three network systems. Our experimental results show that the proposed approach is applicable and effective. | Kangyu Huang Lin Yang Renfang Fu Shengli Zhou Zheng Hong | 2019 | China Communications2019，16，5： | 1 |
| 13 | The Stepwise Pricing Mechanism Research of Residents' Living Power 显示文摘 | Li Renfang Sun Luping GuoSidaia | 2011 | Energy Procedia2011，5，： | 1 |
| 14 | Boron alleviates aluminum toxicity in pea (Pisum sativum)显示文摘 | Min Yu Renfang Shen Hongdong Xiao Miaomiao Xu Huizhen Wang Huoyan Wang Qilong Zeng Jianfeng Bian | 2009 | Plant and Soil (-)2009，，1： | 1 |
| 15 | Characterization of methylated and unmethlyated CpG oligodeoxynucleotides by electrospray ionization tandem mass spectrometry显示文摘 | MA Huiming ZHANG Wenbing SONG Renfang | 2005 | Eur J Mass Spectrom2005，11，： | 1 |
| 16 | Analysis of DNA methylation by tandem ion-pair reversed- phase high-performance liquid chromatography/electrospray ionization mass spectrometry显示文摘 | CHEN Huayong ZHANG Wenbing SONG Renfang | 2004 | Rapid Commun Mass Spectrom2004，18，： | 1 |
| 17 | Robust denoising of point-sam- pled surfaces 显示文摘 | Li Jifang Wang Renfang | 2009 | WSEAS Transactions on Computers2009，8，1： | 1 |
| 18 | Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells 显示文摘 | Renfang S Tiago LD Gabriela MA | 2009 | Toxicology Letters2009，185，1： | 1 |
| 19 | Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway显示文摘Calpain 小子单元(Capn4 ) 1 被显示了与清楚的房间的转移 / 侵略相关肾的房间癌(ccRCC ) 。这研究试图进一步阐明位于调停 Capn4 的 ccRCC 下面的分子的机制前进。在 ccRCC 房间的 mRNA 表示层次被量的即时 PCR 测量。房间粘附,侵略,和移植上的 Capn4 的效果被房间粘附试金,房间侵略试金,和愈合创伤的试金分别地检验。蛋白质层次被西方的污点分析检测。在 vivo 的癌症转移上的 Capn4 的效果在一个裸体老鼠异种皮移植模特儿被估计。Capn4 在 ccRCC 房间是起来调整的,这被发现,并且 Capn4 overexpression 压制了房间粘附活动并且在 786-O 房间增加了房间侵略和移植,当 Capn4 silencing 增加了房间粘附活动并且损害了侵略和 Caki-1 房间的迁居能力时。Capn4 overexpression 也在 786-O 房间增加了劈开的 talin 的蛋白质水平,当 Capn4 silencing 减少了时在 Caki-1 房间的劈开的 talin 的蛋白质水平。发信号的焦点的粘附 kinase (FAK )/AKT/MAPK 被 Capn4 overexpression 在 786-O 房间激活,并且被 Capn4 下面规定在 Caki-1 房间禁止。Capn4 overexpression 增加了矩阵 metalloproteinase 的蛋白质层次 2 (MMP-2 ) ,在 786-O 房间的 vimentin, N-cadherin,和下面调整的 E-cadherin 当 Capn4 silencing 减少了时,蛋白质在 Caki-1 房间 MMP-2, vimentin, N-cadherin,和起来调整的 E-cadherin 铺平。Capn4 也支持了癌症转移在在里面 vivo 裸体人老鼠异种皮移植模型。我们的结果含有在 ccRCC 侵略和移植的 Capn4 的功能的角色,它可以在 ccRCC 贡献癌症转移。 | Qianfeng Zhuang Weiping Luo Mingran Zhang Min Fan Hao Lu Renfang Xu Xiaozhou He | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 1 |
| 20 | Yosypiv genetics of congenital anomalies of the kidney and urinary tract, fuctional models for congenital anomalies of the kidney and urinary tract显示文摘 | Renfang Song Ihor V | 2011 | Pediatric Nephrology2011，26，3： | 1 |
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