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| 1 | Hepatocellular adenoma: An unsolved diagnostic enigma显示文摘Hepatocellular adenoma (HCA) is a rare benign liver tumour associated with the use of oral contraceptives or other steroid medications which occurs predominantly in young and middle-aged women. Unlike other benign liver tumours, an HCA may be complicated by bleeding and malignant transformation. HCAs have been divided into four subtypes based on molecular and pathological features: hepatocyte nuclear factor 1α-mutated HCA, inflammatory HCA,β-catenin-mutated HCA, and unclassified HCA.β-cateninmutated HCA has the highest risk of haemorrhage or malignant transformation. In the latest upgrade of the guidelines regarding the management of benign liver tumours published in 2016 by the European Association for the Study of the Liver, magnetic resonance imaging (MRI) was recognized to be superior to all other imaging modalities in detecting HCAs and in being able to subtype HCAs up to 80%, with positive identification of 1α-mutated HCA or inflammatory HCA achievable with > 90% specificity. This review analyzed the imaging features of HCA using MRI with hepato-specific contrast agents, focusing on the limitations in the HCA characterization. | Matteo Renzulli Alfredo Clemente Francesco Tovoli Salvatore Cappabianca Luigi Bolondi Rita Golfieri | 2019 | World Journal of Gastroenterology2019，25，20： | 12 |
| 2 | Non-invasive tests for the prediction of primary hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies in the world and it is one of the main complications of cirrhosis and portal hypertension.Even in the presence of a well-established follow-up protocol for cirrhotic patients,to date poor data are available on predictive markers for primary HCC occurrence in the setting of compensated advanced chronic liver disease patients(cACLD).The gold standard method to evaluate the prognosis of patients with cACLD,beyond liver fibrosis assessed with histology,is the measurement of the hepatic venous pressure gradient(HVPG).An HVPG≥10 mmHg has been related to an increased risk of HCC in cACLD patients.However,these methods are burdened by additional costs and risks for patients and are mostly available only in referral centers.In the last decade increasing research has focused on the evaluation of several,simple,non-invasive tests(NITs)as predictors of HCC development.We reviewed the currently available literature on biochemical and ultrasound-based scores developed for the noninvasive evaluation of liver fibrosis and portal hypertension in predicting primary HCC.We found that the most reliable methods to assess HCC risk were the liver stiffness measurement,the aspartate aminotransferase to platelet ratio index score and the fibrosis-4 index.Other promising NITs need further investigations and validation for different liver disease aetiologies. | Giovanni Marasco Antonio Colecchia Giovanni Silva Benedetta Rossini Leonardo Henry Eusebi Federico Ravaioli Elton Dajti Luigina Vanessa Alemanni Luigi Colecchia Matteo Renzulli Rita Golfieri Davide Festi | 2020 | World Journal of Gastroenterology2020，26，24： | 8 |
| 3 | Large regenerative nodules in a patient with Budd-Chiari syndrome after TIPS positioning while on the liver transplantation list diagnosed by Gd-EOB-DTPA MRI显示文摘BACKGROUND:Large regenerative nodules (LRNs) are hyperplastic benign nodules most commonly associated with Budd-Chiari syndrome (BCS),caused by outflow obstruction of the hepatic veins or vena cava.To our knowledge,no cases of LRNs arising in BCS after transjugular intrahepatic portosystemic shunt (TIPS) positioning and detected by GdEOB-DTPA MRI have been reported in the literature.METHODS:A 58-year-old woman with BCS,on the liver transplantation (LT) list,underwent a follow-up enhanced MRI.Two years earlier,a TIPS had been placed.In 2008,recurrent hepaticoencephalopathy resistant to medical treatment fulfilled the LT criteria for BCS treated with TIPS and the patient was therefore added to the LT list.CT performed before TIPS had not detected any hepatic lesions.CT performed six months after TIPS showed its complete patency but documented two indeterminate hypervascular liver lesions.RESULTS:MRI performed with Gd-EOB-DTPA revealed additional hypervascular lesions with uptake and retention of the medium in the hepatobiliary phase,thus reflecting a benign behavior of hepatocellular composition.These MRI features were related to LRNs as confirmed by histopathologic analysis.CONCLUSIONS:Gd-EOB-DTPA-enhanced MRI is potentially superior to standard imaging using gadolinium chelates or spiral CT,especially for the differential diagnosis of hypervascular lesions.Gd-EOB-DTPA MRI may become the imaging method of choice for evaluating LT list patients with BCS after TIPS placement. | Matteo Renzulli Vincenzo Lucidi Cristina Mosconi Chiara Quarneti Emanuela Giampalma Rita Golfieri | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 5 |
| 4 | Response rate and clinical outcome of HCC after first and repeated cTACE performed “on demand”显示文摘 | E. Terzi R. Golfieri F. Piscaglia M. Galassi A. Dazzi S. Leoni E. Giampalma M. Renzulli L. Bolondi | 2012 | Journal of Hepatology2012，，6： | 4 |
| 5 | Obstruction of Mechanical Mitral Prostheses: Analysis of Pathologic Findings显示文摘 | Nicola Vitale Attilio Renzulli Lucio Agozzino Alessio Pollice Nicola Tedesco Luigi de Luca Tupputi Schinosa Maurizio Cotrufo | 1997 | The Annals of Thoracic Surgery1997，，4： | 2 |
| 6 | Serous papillarycystadenoma of borderline malignancy of the broad ligament显示文摘 | Loverro G Cormio G Renzulli G | 1997 | Eur J Obstetr Gynecol Reprod Biol1997，74，2： | 1 |
| 7 | What makes giftedness? Re-examining a definition 显示文摘 | RENZULLI J S | 1978 | Phi Delta Kappa1978，60，18： | 1 |
| 8 | Use of accurate diagnostic criteria may increase incidence of stercoral perforation of the colon显示文摘 | Maurer C A Renzulli P Mazzucchelli L | 2000 | Dis Colon Rectum2000，43，7： | 1 |
| 9 | Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanes显示文摘 | Galletti E Magnani M Renzulli M L | 2007 | Chem Med Chem2007，2，7： | 1 |
| 10 | Paclitaxel and docetaxel resistance:molecular mechanisms and development of new eneration taxanes显示文摘 | Galletti E Magnani M Renzulli ML | | 0，，07： | 1 |
| 11 | The Gab2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer 显示文摘 | Mira A Isella C Renzulli T | 2009 | Oncogene2009，28，50： | 1 |
| 12 | Passing on privilege:re-sources provided by self-employed parents to their self-employed children显示文摘 | Aldrich H Renzulli L Lang-ton N | | 0，，16： | 1 |
| 13 | Contribution of the hepatobiliary phase of Gd-EOB DTPA enhanced MRI to Dynam- ic MRI in the detection of hypovaseular small (≤2 cm) HCC in cirrhosis显示文摘 | Golfieri R Renzulli M Lucidi V | 2011 | Eur Radiol2011，21，6： | 1 |
| 14 | Family Matters : Gender, Networks, and Entrepreneurial Outcomes 显示文摘 | Renzulli L A Aldrich H Moody J | 2000 | Social forces2000，79，2： | 1 |
| 15 | Laparoscopic management of nonparasitic symptom-producing solitary hepatic cysts显示文摘 | Krjenb L Baer HU Renzulli P | 1996 | J Am Coll Surg1996，183，5： | 1 |
| 16 | The impact of the introduc- tion of total mesorectal excision on local recurrence rate and sur-viral in rectal cancer: long-term results 显示文摘 | Maurer CA Renzulli P Kull C | 2011 | Ann Surg Oncol2011，18，7： | 1 |
| 17 | Expanding the conception of giftedness to include co-cognitive traits and to promote social capital 显示文摘 | RENZULLI J S | 2002 | PhiDeha Kappan2002，，9： | 1 |
| 18 | Family Matters:Gender,networks,and Entrepreneurial Outcomes显示文摘 | Renzulli L.A Aldrich H Moody J | | 0，，2： | 1 |
| 19 | Management of blunt injuries to the spleen 显示文摘 | Renzulli P Gross T Schoepfer AM | 2010 | Br J Surg2010，97，16： | 1 |
| 20 | Obstruction of mechanical mitral prostheses: analysis of pathologic findings显示文摘 | Vitale N Renzulli A Agozzino L | 1997 | Ann Thorac Surg1997，63，4： | 1 |
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