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| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 3 | 2-Week triple therapy for Helicobacter pylori infection is better than 1-week in clinical Practice: a large prospective single-center randomized st udy显示文摘 | Paoluzi P Iacopini F Crispino P Nardi F Bella A Rivera M Rossi P Gurnari M Caracciolo F Zippi M Pica R | 2006 | Helicobacter2006，11，： | 1 |
| 4 | Thermal integration of heat pumping systems in distillation columns 显示文摘 | P Rivera - Ortega M picon - Nunez E Tortes - reyes A Gallegos - Munoz | 1999 | Applied Thermal Engi- neering1999，19，81： | 1 |
| 5 | Clinical nurse resource:a new role designed to supplement vacant clinical nurse spe- cialist positions显示文摘 | Johnston P Meyers A Rivera Z | 2006 | Oncology Nursing Forum2006，33，2： | 1 |
| 6 | Renal dysfunction as a consequence of acute liver damage by bile duct ligation in cirrhotic rats 显示文摘 | Rivera H S Sanchez A R Covarrubias P A | 2006 | Exp Toxicol Patho12006，58，23： | 1 |
| 7 | Leveraging intensive longitudinal data to better understand health behaviors显示文摘 | Timms K P Martin C A Rivera D E | 2014 | Conf Proe IEEE Eng Med Biol Soe2014，，： | 1 |
| 8 | Evaluation of renal grafts in patients with lupus nephritis as cause of end-stage renal disease显示文摘 | Villaverde Verdejo P Fernández Rivera C Alonso Hernández A | | 0，，03： | 1 |
| 9 | Change in quantitativehuman chorionic gonadotropin after manual vacuum aspi-ration in women with pregnancyof unknown location 显示文摘 | Rivera V Nguyen P H Sit A | 2009 | Am J Obstet Gynecol2009，200，5： | 1 |
| 10 | A noteon thedynamic and static displacementsfromapointsource in muhilayered media显示文摘 | Zhu L P Rivera L A | 2002 | Geophysical Journal In- ternational2002，148，3： | 1 |
| 11 | Photocatalytic degradation of pollutant over TiO2 in different crystal structures 显示文摘 | RIVERA A P TANAKA K HISANAGA T | 1993 | Appl Catal B1993，3，： | 1 |
| 12 | Problem-solving training for family caregivers of persons with traumatic brain injuries: a randomized controlled trial显示文摘 | Rivera P A Elliott T R Berry J W | 2008 | Arch Phys Med Rehabil2008，89，5： | 1 |
| 13 | The effect of soy oligosaccharide extraction on diet digestibility, faecal characteris- tics, and intestinal gas production in dogs显示文摘 | FeLix A P Rivera N L M Sabehuk T T | 2013 | Animal Feed Sci- ence & Technology2013，184，14： | 1 |
| 14 | Cpk index estimation using data transformation显示文摘 | Rivera L A R Hubele N F Lawrence F P | 1996 | Computers and Industrial Engineering1996，29，1： | 1 |
| 15 | Common occurrence of enterotoxin genes and enterotoxicity in Bacillus thuringiensis显示文摘 | RIVERA A M G GRANUM P E PRIEST F G | 2000 | FEMS Microbiology Letters2000，190，1： | 1 |
| 16 | X-ray absorption spectroscopic study of Fe reference compounds for the analysis of natural sediments显示文摘 | O'day P A Rivera J R N Root R | 2004 | American Mineralogist2004，89，： | 1 |
| 17 | A note on the dynamic and static displacements from a point source in multilayered media显示文摘 | Zhu L P Rivera L A | 2002 | Geophysical Journa International2002，148，3： | 1 |
| 18 | Biological applications of gold nanoparticles 显示文摘 | Sperling R A Rivera Gil P Zhang F Zanella M Parak W J | 2008 | Chemical Society Reviews2008，37，9： | 1 |
| 19 | Supercritical carbon dioxide extraction as a predictor of polycyelic aromatic hydrocarbon bioaceumulation and toxicity by earthworms in manufactured-gas plant site soils显示文摘 | Kreitinger J P Rivera A Q Neuhanser E F | 2007 | Environ Toxicol Chem2007，26，9： | 1 |
| 20 | Targeted therapy for the treatment of ad- vanced non-small cell lung cancer: a review of the epidermal growth factor receptor antagonists显示文摘 | Silvestri G A Rivera M P | 2005 | Chest2005，128，6： | 1 |
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