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| 1 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 4 | Role of anthracycline- based therapy in the adjuvant treatment of breast cancer: Efficacy analyses determined by molecular subtypes of the disease 显示文摘 | Slamon D J Mackey J Robert N | 2007 | Breast Cancer Res Treat2007，106，： | 1 |
| 5 | Coupled thermo-mechanical waves in hyperbolic thermoelasticity显示文摘 | STRUNIN D V MELNIK R V N ROBERTS A J | 2001 | Journal of Thermal Stresses2001，24，： | 1 |
| 6 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 7 | Mechanically Coupled Ears for Directional Hearing in the Parasitoid fly Ormia Ochracea显示文摘 | MILES R N ROBERT D HOY R R | 1995 | Journal of the Acoustical Society of America1995，98，6： | 1 |
| 8 | Presss industry seismic workshops: concept development显示文摘 | SUZANNE D N ROBERT E E | 1991 | PCI Journal1991，36，5： | 1 |
| 9 | Phase Ⅲ randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC→T) with doxorubicin and cyclophosphamide followed by docetax- el and trastuzumab (AC→TH) with docetaxel, carboplatin and trastu- zumab(TCH) in HER2 positive early breast cancer patients: BCIRG 006 study显示文摘 | Slamon D Eiermann W Robert N | 2006 | Breast Cancer Res Treat2006，100，1： | 1 |
| 10 | Clayey barrier assessment for impoundment of domestic waste leachate (southernOntario) including clay-leachate compatibility by hydraulic conductivity testing显示文摘 | ROBERT M QUIGLEYF EDERICOFE RNANDEZA KERRYR OW N D R | 1988 | Canadian Geotechnical Journal1988，25，2： | 1 |
| 11 | Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates显示文摘 | Deb N Chakravarti Michael J Fiske Leah D Fletcher Robert J Zagursky | 2001 | Vaccine2001，，6： | 1 |
| 12 | Hydraulic Performance of a Steep Single Layer Riprap Drainage Channel显示文摘 | ROBERT N E DONALD D G | 2008 | Journal of Hydraulic Engineering2008，134，11： | 1 |
| 13 | Adjuvant trastuzumab in HER2-positive breast cancer 显示文摘 | Simon D Eiermann W Robert N | 2011 | N EngI J Med2011，365，14： | 1 |
| 14 | A model for the response of seated humans to sinusoidal displacements of the seat显示文摘 | ROBERT M CHARLES D N | 1974 | Journal of Biomechanics1974，7，3： | 1 |
| 15 | Adjuvant trastuzumab in HER2-Positive breast cancer显示文摘 | Slamon D Eiermann W Robert N | 2011 | N Engl J Med2011，365，14： | 1 |
| 16 | Impacts of desalination plant discharges on the marine environment: A critical review of published studies显示文摘 | Roberts D A Johnston E L Knott N A | 2010 | Water Research2010，44，18： | 1 |
| 17 | Interpolation using surface splines 显示文摘 | Robert L H Robert N D | 1972 | AIAA Journal1972，9，2： | 1 |
| 18 | Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial 显示文摘 | Robert N J Saleh M N Paul D | 2011 | Clin Breast Cancer2011，11，2： | 1 |
| 19 | Membrane fouling reduction by backpulsing and surface modification显示文摘 | Ma H M Christopher N B Robert H D | 2000 | Journal of Membr Sci2000，173，： | 1 |
| 20 | Influence ofvariability in motivation and affect on elite athlete burnout sus-ceptibility 显示文摘 | LEMYRE P N TREASURE D C ROBERTS G C | 2006 | J Sport Exe Psychol2006，28，： | 1 |
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