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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Epidermal growth factor induced intracellular Ca2+ oscillations in microvascular endothelial cells显示文摘 | Francesco M Roberto B Simona T | 2003 | J Cell Physiol2003，194，2： | 1 |
| 3 | Using weather ensemble predic- tions in electricity demand forecasting 显示文摘 | James W T Roberto B | 2003 | International Journal of Forecasting2003，，19： | 1 |
| 4 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 5 | Tumor Inflammatory Angiogenesis and Its Chemoprevention显示文摘 | Adriana A Francesca T Roberto B | 2005 | Cancer Res2005，65，10： | 1 |
| 6 | Clinical and pharmacological prdile in a clenbuterol epidemic poisoning of contaminated beef in Italy 显示文摘 | Gianfranco B Roberto A Pietro T | 2000 | Toxicol lett2000，14，： | 1 |
| 7 | A methodology to design arbitrar- y failure detectors for distributed protocols 显示文摘 | Roberto B Jean M H Sara T P | 2008 | Journal of Sys- tems Architecture2008，54，7： | 1 |
| 8 | Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients显示文摘 | Giovanni T Lorenzo B Roberto P | 2006 | Clin Endocrinol (Oxf)2006，65，5： | 1 |
| 9 | Discovery of a new f unction of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alle viates ischemia/reperfusion injury and mediates the late phase of preconditioni ng显示文摘 | Roberto B Ken S Xian-Liang T | 2002 | Cardiovascular Research2002，55，： | 1 |
| 10 | Interventional and intraoperative MRI at low field scanner-a review显示文摘 | Roberto T B Ojala R Kariniemi J | 2005 | Eur J Radiol2005，56，2： | 1 |
| 11 | Influence of genetic andenvironmental factors on chemical profilc and antioxidant potential ofcommercial strawberry (Fragaria × ananassa, Duchesne)显示文摘 | RITA B ARMANDAO T ROBERTO L S | 2009 | Journal ofEnvironmental Agricultural and Food Chemistry2009，8，4： | 1 |
| 12 | Determination of nitrofuran metabolites in seafood by ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry 显示文摘 | NOELIA M V T PATRICIA P B ROBERTO R G | 2013 | Journal of Food Composition and Analysis2013，30，2： | 1 |
| 13 | A theoretical study of CIONO2 + CI →CI2 + NO3^- on ice显示文摘 | ROBERTO B JAMES T H | 2003 | J Phys Chem A2003，107，： | 1 |
| 14 | The generalized bin packing problem显示文摘 | Mauro M B Teodor G C Guido P Roberto T | 2012 | Transpurtation Research Part E2012，48，6： | 1 |
| 15 | Eucalyptus urophylla root growth,stem sprouting and nutrient supphy from the roots and soil显示文摘 | Panlo C T Roberto F N Nairam F B | 2002 | Forest Ecology and Management2002，160，2： | 1 |
| 16 | Recent advances in vehicle routing exact algorithms显示文摘 | Roberto B Paolo T Daniele V | 2007 | 4OR: A Quarterly Journal of Operations Research2007，5，4： | 1 |
| 17 | Emerging collective behavior and local properties of financial dynamics in a public investment game 显示文摘 | Roberto D S Ana L C B Alexandre T B | 2006 | Physica A : Statistical and Theoretical Physics2006，371，2： | 1 |
| 18 | 显示文摘 | Roberto B Robert L Kuhn T | 1996 | ComputationalMaterials Science1996，5，： | 1 |
| 19 | Microgllal microvesicle secretion and intercellular signaling显示文摘 | Elena T Roberto F Fabio B | 2012 | Front Physiol2012，3，： | 1 |
| 20 | A new proposal for power quality and custom power improvement:OPEN UPQC显示文摘 | MORRIS B ROBERTO F ENRICO T | 2009 | IEEE Transactions on Power Delivery2009，24，4： | 1 |
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