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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism显示文摘 | Deretic V Singh S Master S Harris J Roberts E Kyei G Davis A Haro S Naylor J Lee HH Vergne I | | Cell Microbiol0，8，5： | 1 |
| 3 | Postoperative nausea and vomiting are strongly influenced by post- operative opioid use in a dose-related manner显示文摘 | Roberts GW Beker TB Carlsen HH | 2005 | Anesth Analg2005，101，11： | 1 |
| 4 | Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner显示文摘 | Roberts GW Bekker TB Carlsen HH | 2005 | Anesth Analg2005，101，5： | 1 |
| 5 | Postoperative nausea and Vomiting are strongly influenced by postoperative Opioid use in a dose-related manner显示文摘 | Roberts GW Bekker TB Carlsen HH Moffatt CH Slattery PJ McClure AF | | 0，，05： | 1 |
| 6 | Postoperative nauseaand vomiting are strongly influenced by postoperative opioid use in adose - related manner 显示文摘 | Roberts GW Bekker TB Carlsen HH | 2005 | Anesthesia and Analgesia2005，101，5： | 1 |
| 7 | Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner 显示文摘 | Roberts GW Bekker TB Carlsen HH | 2005 | Anesth Analg2005，101，5： | 1 |
| 8 | Positive behavior sup- port : evolution of an applied Science 显示文摘 | Edward G C Glen D Robert HH | 2002 | Journal of Positive Behavior In- terventions2002，，1： | 1 |
| 9 | Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage 显示文摘 | Alice HH MeganJF Robert LM | 2010 | J Biomech2010，43，： | 1 |
| 10 | A relationship between cancer of stomach and the ABO blood groups显示文摘 | Aird I Bentall HH Roberts JA | 1953 | Br Med J1953，1，4814： | 1 |
| 11 | Relevant activities of extracts andconstituents of animals used in traditional Chinese medicine for centralnervous system effects associated with Alzheimer^ disease 显示文摘 | Ren YH Peter Hh Robert CH | 2006 | 7 PharPharmacol2006，58，： | 1 |
| 12 | A simple quantitative tech- nique for testing behavioural responses of Schistosoma mansoni miracidia to chemicals 显示文摘 | Roberts TM Stibbs HH Chermin E | 1978 | J Parasitol1978，64，2： | 1 |
| 13 | Targeted recruitment of Set1 histone methylase by elongating Pol Ⅱ provides a localized mark and memory of recent transcriptional activity 显示文摘 | Ng HH Robert F Young RA | 2003 | Mol Cell2003，11，3： | 1 |
| 14 | Postoperative nausea and vomiting are strongly influenced by postoperative o-pioid use in a dose-related manner显示文摘 | Roberts GW Bekker TB Carlsen HH | 2005 | Anesth Analg2005，101，5： | 1 |
| 15 | An animal model of cigarette smoke-induced in utero growth retardation 显示文摘 | Emily RE Kristin HH Robert MG | 2008 | Toxicology2008，246，： | 1 |
| 16 | A simple quantitative technique for testing behavioral responses of Schistosoma mansoni miracidia to chemicals 显示文摘 | Roberts TM Stibbs HH Chernin E | 1978 | J Parasitol1978，64，2： | 1 |
| 17 | Leucocyte analysis using monoclonal antibodies in human glomerulonephritis显示文摘 | David HH David CG Robert CA | 1987 | Kidney Int1987，31，4： | 1 |
| 18 | Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse显示文摘 | Robert US Steven HH | 2007 | J Steroid Biochem Mol Biol2007，103，35： | 1 |
| 19 | Protein geranylgeranylation isrequired for osteoclast formation,function,and survival : inhibitionby bisphosphonates and GGTI-29 显示文摘 | Fraser PC Miep HH Robert Yf | 2000 | Bone Miner Res2000，15，8： | 1 |
| 20 | A relationship between cancer of stomach and the ABQ blood groups 显示文摘 | Aird I Bentall HH Roberts JA | 1953 | Br Med J1953，1，4814： | 1 |
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