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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Mathematical simulation of radial heat transfer in packed beds by pseudohomogeneous modeling显示文摘Uniform flow regime and constant effective thermal conductivity inside packed beds are commonly accepted in the evaluation of the fluid dynamics and heat transfer in such systems.However,several authors have confirmed the presence of an oscillatory velocity profile caused by the effective contribution of porosity profile in the fluid dynamic behavior of packed beds,which directly influences the heat transfer inside the beds.This paper describes the application of a pseudo-homogeneous mathematical model for describing heat transfer in packed beds with oscillatory profiles of velocity and porosity,using a radius-dependent model for effective thermal conductivity k r.Several temperature profiles were obtained in a packed bed system with thermal source located on the wall.The simulated temperature and effective thermal conductivity obtained from simulations were compared with experimental data and calculation from a model based on uniform k r fitting.The results indicate that the proposed mathematical modeling was capable of better representing the heat transfer in the packed bed. | Rodrigo Béttega Marcos Flávio Pinto Moreira Ronaldo Guimaraes Corrêa José Teixeira Freire | 2011 | Particuology2011，9，2： | 2 |
| 3 | Alkaline proteinase from intestine of nile tilapia (Oreochromis Niloticus)显示文摘 | Ranilson S B Eduardo J F L Rodrigo B A | 2005 | Process Biochemistry2005，40，： | 1 |
| 4 | Dry sliding wear behaviour of ZE41A magnesium alloy 显示文摘 | LOPEZ A J RODRIGO P TORRES B RAMS J | 2011 | Wear2011，271，1112： | 1 |
| 5 | Effects of supercritical carbon dioxide on waste banana peels for heavy metal removal显示文摘 | Juliana Q A Rodrigo B R Diego T S | 2011 | The Journal of Supercritical Fluids2011，58，： | 1 |
| 6 | Cyclin/PCNA is the auxiliary protein ofDNA polymerase-δ显示文摘 | Rodrigo B Rainer F Patricia A | 1987 | Nature1987，326，： | 1 |
| 7 | An economic assessment of proteins recovery from fish meal effluents by uhrafiltration显示文摘 | Marai D A Javier F Rodrigo B | 2004 | Trends in Food Science & Technology2004，15，10： | 1 |
| 8 | Data stream clustering: A survey显示文摘 | JONATHAN A S ELAINE R F~ RODRIGO C B | 2013 | ACM Computing Sur- veys2013，46，1： | 1 |
| 9 | 显示文摘 | Maria D A Rodrigo B Y | 2001 | Desalination2001，139，： | 1 |
| 10 | Human immunodeficiency virus infection modifies the natural history of chronic parenterally-acquired hepatitis C with and unusually rapid progression to cirrhosis 显示文摘 | Soto B Sanchez-Quijano A Rodrigo A | 1997 | J Hepatol1997，26，1： | 1 |
| 11 | Adaptive granular local search heuristic for a dynamic vehicle routing problem显示文摘 | Rodrigo M B Vinícius A A | 2009 | Computers&Operations Research2009，36，11： | 1 |
| 12 | Adaptive granular local search heuristic for a dynamic vehicle routing problem显示文摘 | Rodrigo M B Vinicius A A | 2009 | Computers and Operations Research2009，36，11： | 1 |
| 13 | Performance of Pacific white shrimp Litopenaeus vannamei raised in biofloc systems with varying levels of light exposure 显示文摘 | MANECAS B RAFAEL A RODRIGO S | 2013 | Aquacuhural Engineering2013，52，： | 1 |
| 14 | Alkalineprotease from intestine of Nile tilapia显示文摘 | RANILSON S B EDUARDO J F L RODRIGO B A | 2005 | Process Biochemistry2005，40，： | 1 |
| 15 | Cyclin/PCNA is the auxiliary protein of DNA polymerase - 8 显示文摘 | Rodrigo B Rainer F Patricia A | 1987 | Nature1987，326，： | 1 |
| 16 | Chaotic advection and heat transfer enhancement in stokes flows显示文摘 | LEFEVRE A MOTA J P B RODRIGO A J S | 2003 | International Journal of Heat and Fluid Flow2003，24，： | 1 |
| 17 | 利匹韦林通过选择性STAT1介导的肝星状细胞凋亡改善肝纤维化显示文摘【据《Gut》2019年9月报道】题:利匹韦林通过选择性STAT1介导的肝星状细胞凋亡改善肝纤维化(作者Martí-Rodrigo A等)。肝纤维化发病率逐年上升,缺乏具体有效的治疗措施,已经成为一个重大的公共卫生问题。大量研究结果表明,机体主要通过细胞因子激活JAK-STAT通路来调节肝纤维化和肝细胞再生。利匹韦林是一种临床上广泛应用的抗HIV药物,目前尚无肝毒性报道。本研究中,来自西班牙瓦伦西亚大学大学医学院药理学系的Martí-Rodrigo等主要研究了利匹韦林在几种慢性肝损伤模型中的肝脏保护作用,并研究了其作用机制:JAK-STAT信号调节。研究人员利用营养性非酒精性脂肪肝、四氯化碳致肝纤维化和胆管结扎致肝纤维化三种小鼠模型,研究了利匹韦林对肝脂肪变性、炎症和纤维化的影响。并利用原代人肝星状细胞,人肝细胞株lx-2、hep3b研究了其潜在的分子机制。 | 任天棋 杨倩倩 乔天一 牛俊奇 MART■-RODRIGO A ALEGRE F MORAGREGA ■B | 2020 | 临床肝胆病杂志2020，36，1： | 1 |
| 18 | Isobaric vapor-liquid equilibria of the water + 2-propanol system at 30,60, and 100 kPa显示文摘 | Marzal P Montn J B Rodrigo M A | 1996 | J Chero Eng Data1996，41，： | 1 |
| 19 | Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer显示文摘 | Rodrigo A Bengt B Ariane D | 2004 | New England Journal of Medicine2004，350，4： | 1 |
| 20 | Palladium and Mo-lybdenum Mono and Bimetallic Catalysts on Modernitefor Direct NO Decomposition Reaction显示文摘 | Rodrigo S Andréa M Sibele B etc | 2009 | Catalysis Let-ters2009，129，34： | 1 |
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