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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Acute liver failure-in- duced death of rats is delayed or prevented by blocking NMDA receptors in brain显示文摘 | Cauli O Rodrigo R Boix J | 2008 | Am J Physiol Gastrointest Liver Physiol2008，295，3： | 1 |
| 3 | Synthesis of 9-deoxo-9a-aza- 9a-homoerythromycin A 11, 12-hydrogen borate and azithromycin 11,12-hydrogen borate: a new procedure to obtain azithromycin dihydrate显示文摘 | Miguel B J Rodrigo J C Fernando L O | 1997 | Journal of Organic Chemistry1997，62，21： | 1 |
| 4 | Acute liver failure-induced death of rats is delayed or prevented by blocking receptors in brain显示文摘 | Cauli O Rodrigo R Boix J | 2008 | Am J Physiol2008，295，3： | 1 |
| 5 | Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts显示文摘 | Cauli O Rodrigo R Piedrafita B Boix J Felipo V | 2007 | Hepatology2007，46，： | 1 |
| 6 | Distribution of nitric oxide synthase in the esophagus of the cat and monkey 显示文摘 | Rodrigo J Uttenthal L O Peinado M A | 1998 | Journal of the Autonomic Nervous System1998，70，： | 1 |
| 7 | Differential regulation of Pyk2 phosphorylation at Tyr-402 and Tyr-580 in intestinal epithelial cells:Roles of calcium,Src,Rho kinase,and the cytoskeleton显示文摘 | Steven S W Rodrigo O J Sheung K V | 2006 | Cellular Signalling2006，18，： | 1 |
| 8 | Scale invariant feature approach for insect monitoring显示文摘 | Luis O Solis-Sanchez Rodrigo Castafieda-Miranda Juan J Garcia- Escalante | 2011 | Computers and Electronics in Agriculture2011，，75： | 1 |
| 9 | Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts显示文摘 | Cauli O Rodrigo R Piedrafita B Boix J Felipo V | 2007 | Hepatology2007，46，： | 1 |
| 10 | Role of NMDA receptors in acute liver failure and ammonia toxicity: therapeutical implications显示文摘 | Rodrigo R Cauli O Boix J | 2009 | NeurochemInt2009，55，13： | 1 |
| 11 | Distribution of nitric oxide synthase in the esophagus of the cat and monkey 显示文摘 | Rodrigo J Uttenthal L O Peinado M A | 1998 | Journal of the Autonomic Nervous System1998，70，： | 1 |
| 12 | Distribution of nitric oxide synthase in the esophagus of the cat and monkey显示文摘 | Uttenthal L O Peinado M A | 1998 | Journal of the Autonomic Nervous System1998，70，： | 1 |
| 13 | Development of a citrus genomewide EST collection and cDNA microarray as resources for genomic studies显示文摘 | FORMENT J GADEA J HUERTA L ABIZANDA L AGUSTI J ALAMAR S ALOS E ANDRES F ARRIBAS R BELTRAN J P BERBEL A BLAZQUEZ M A BRUMOS J CANAS L A CERCOS M COLMENERO-FLORES J M CONESA A ESTABLES B GANDIA M GARCIA-MARTINEZ J L GIMENO J GISBERT A GOMEZ G GONZALEZ-CANDELAS L GRANELL A GUERRI J LAFUENTE M T MADUENO F MARCOS J F MARQUES M C MARTINEZ F MARTINEZ-GODOY M A MIRALLES S MORENO P NAVARRO L PALLAS V PEREZ-AMADOR M A PEREZ-VALLE J PONS C RODRIGO I RODRIGUEZ P L ROYO C SERRANO R SOLER G TADEO F TALON M TEROL J TRENOR M VAELLO L VICENTE O VIDAL C ZACARIAS L CONEJERO V | 2005 | Plant Molecular Biology2005，57，3： | 1 |
| 14 | Localization of nitric oxide in the adult rat brain显示文摘 | Rodrigo J Springall DR Uttenthal O | 1994 | Philos Trans R Soc Lond B Biol Sci1994，345，2： | 1 |
| 15 | Molecular diagnostic methods in the diagnosis and follow-up of well-differentiated thyroid carcinoma显示文摘 | Rodrigo J P Rinaldo A Devaney K O | 2006 | Head Neck2006，28，11： | 1 |
| 16 | Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain显示文摘 | Cauli O Rodrigo R Boix J | 2008 | Am J Physiol Gastrointest Liver Physiol2008，295，3： | 1 |
| 17 | Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic显示文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction. | Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sugimura Masaaki Uno Yohei Takenobu Yuji Matsumaru Satoshi Yamada Ryuhei Kono Takuya Kanamaru Masafumi Morimoto Junichi Iida Vasu Saini Dileep Yavagal Saif Bushnaq Wenguo Huang Italo Linfante Jawad Kirmani David S Liebeskind Viktor Szeder Ruchir Shah Thomas G Devlin Lee Birnbaum Jun Luo Anchalee Churojana Hesham E Masoud Carlos Ynigo Lopez Brendan Steinfort Alice Ma Ameer E Hassan Amal Al Hashmi Mollie McDermott Maxim Mokin Alex Chebl Odysseas Kargiotis Georgios Tsivgoulis Jane G Morris Clifford J Eskey Jesse Thon Leticia Rebello Dorothea Altschul Oriana Cornett Varsha Singh Jeyaraj Pandian Anirudh Kulkarni Pablo M Lavados Veronica V Olavarria Kenichi Todo Yuki Yamamoto Gisele Sampaio Silva Serdar Geyik Jasmine Johann Sumeet Multani Artem Kaliaev Kazutaka Sonoda Hiroyuki Hashimoto Adel Alhazzani David Y Chung Stephan A Mayer Johanna T Fifi Michael D Hill Hao Zhang Zhengzhou Yuan Xianjin Shang Alicia C Castonguay Rishi Gupta Tudor G Jovin Jean Raymond Osama O Zaidat Raul G Nogueira SVIN COVID-19 Registry,the Middle East North Africa Stroke and Interventional Neurotherapies Organization(MENA-SINO),Japanese Society of Vascular and Interventional Neurology Society(JVIN) | 2021 | Stroke & Vascular Neurology2021，6，4： | 0 |
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