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| 1 | The global significance of biodiversity science in China: an overview显示文摘Biodiversity science in China has seen rapid growth over recent decades,ranging from baseline biodiversity studies to understanding the processes behind evolution across dynamic regions such as the Qinghai-Tibetan Plateau.We review research,including species catalogues;biodiversity monitoring;the origins,distributions,maintenance and threats to biodiversity;biodiversity-related ecosystem function and services;and species and ecosystems'responses to global change.Next,we identify priority topics and offer suggestions and priorities for future biodiversity research in China.These priorities include(i)the ecology and biogeography of the Qinghai-Tibetan Plateau and surrounding mountains,and that of subtropical and tropical forests across China;(ii)marine and inland aquatic biodiversity;and(iii)effective conservation and management to identify and maintain synergies between biodiversity and socio-economic development to fulfil China's vision for becoming an ecological civilization.In addition,we propose three future strategies:(i)translate advanced biodiversity science into practice for biodiversity conservation;(ii)strengthen capacity building and application of advanced technologies,including high-throughput sequencing,genomics and remote sensing;and(iii)strengthen and expand international collaborations.Based on the recent rapid progress of biodiversity research,China is well positioned to become a global leader in biodiversity research in the near future. | Xiangcheng Mi Gang Feng Yibo Hu Jian Zhang Lei Chen Richard T.Corlett Alice C.Hughes Stuart Pimm Bernhard Schmid Suhua Shi Jens-Christian Svenning Keping Ma | 2021 | National Science Review2021，8，7： | 16 |
| 2 | Reverse transcription-PCR analysis of the regulation of the manganese peroxidase gene family显示文摘 | GETTEMY M Jessiea MA Biao ALIC Margaret | 1998 | Applied and Environmental Microbiology1998，64，2： | 1 |
| 3 | Reverse transcription-PCR analysis of the regulation of the manganese peroxidase gene family显示文摘 | GETTEMY JM MA B ALIC M | 1998 | Appl Environ Microbiol1998，64，2： | 1 |
| 4 | Six steps for building a technological knowledge base for future taxonomic work显示文摘Species are the principal category we use to study,understand,and conserve the natural world,so how we define species has a cascading impact across fields,well beyond biology[1].Despite such importance,debate on species concepts continues to this day([2]2020),with consequences for what organisms we recognize,study and protect.Given the wealth of life forms on our planet. | Michael C.Orr Anderson Feijó Douglas Chesters Alfried P.Vogler Silas Bossert Rafael R.Ferrari Mark John Costello Alice C.Hughes Lars Krogmann John S.Ascher Xin Zhou De-Zhu Li Ming Bai Jun Chen Deyan Ge Arong Luo Gexia Qiao Paul H.Williams Ai-bing Zhang Keping Ma Feng Zhang Chao-Dong Zhu | 2022 | National Science Review2022，9，12： | 1 |
| 5 | Use of sulphonylurea and cancer in type 2 diabetes—The Hong Kong Diabetes Registry显示文摘 | Xilin Yang Wing Yee So Ronald C.W. Ma Linda W.Y. Yu Gary T.C. Ko Alice P.S. Kong Vanessa W.S. Ng Andrea O.Y. Luk Risa Ozaki Peter C.Y. Tong Chun-Chung Chow Juliana C.N. Chan | 2010 | Diabetes Research and Clinical Practice2010，，3： | 1 |
| 6 | Challenges and possible solutions to creating an achievable and effective Post-2020 Global Biodiversity Framework显示文摘Global biodiversity is in crisis as a result of human activity.This biodiversity crisis has been well documented by scientists,recognized by world leaders,politicians,businesses,and citizens.Both the biodiversity and climate crises need to be addressed now.2020 was when this change was supposed to start,with the 15th Conference of Parties(COP15)of the Convention on Biodiversity(CBD)meeting in Kunming,and the 26th Conference of Parties(COP26)of the UN Framework Convention on Climate Change meeting in Glasgow,but both meetings were postponed.COP26 was held a year late(November 2021),while COP15 was split into two,with the first part held in Kunming in October 2021,and the second part scheduled for Montreal in December 2022.This meeting in Montreal-arguably the most important in the CBDs history-must agree on the Post-2020 Global Biodiversity Framework(GBF),to reverse biodiversity loss.Failure to reach agreement in Montreal would ultimately be a failure of us all,with irreversible consequences for life on earth.Yet,with three months before the final deadline only 20%of text and two targets are agreed.This paper reviews the factors hindering progress on the agreement and suggests possible solutions. | Alice Hughes Xiaoli Shen Richard Corlett Lin Li Maofang Luo Stephen Woodley Yuanming Zhang Keping Ma | 2022 | Ecosystem Health and Sustainability2022，8，1： | 1 |
| 7 | Glomerular Filtration Rate, Cardiorenal End Points, and All -Cause Mortality intype 2 diabeteic patients 显示文摘 | Wing Yee So Alice P S Kong Ronald C W Ma | 2006 | Diabetes Care2006，29，： | 1 |
| 8 | Severe Hypoglycemia Identifies Vulnerable Patients With Type 2 Diabetes at Risk for Premature Death and All-Site Cancer: The Hong Kong Diabetes Registry显示文摘 | Kong Alice PS Yang Xilin Luk Andrea Ma Ronald CW So Wing Yee Ozaki Risa Ting Rose Cheung Kitty Ho Chung Shun Chan Michael HM Chow Chun Chung Chan Juliana CN | 2014 | Diabetes Care2014，，4： | 1 |
| 9 | Activation of PXR causes drug interactions with Paxlovid in transgenic mice显示文摘Paxlovid is a nirmatrelvir(NMV)and ritonavir(RTV)co-packaged medication used for the treatment of coronavirus disease 2019(COVID-19).The active component of Paxlovid is NMV and RTV is a pharmacokinetic booster.Our work aimed to investigate the drug/herb-drug interactions associated with Paxlovid and provide mechanism-based guidance for the clinical use of Paxlovid.By using recombinant human cytochrome P450s(CYPs),we confirmed that CYP3A4 and 3A5 are the major enzymes responsible for NMV metabolism.The role of CYP3A in Paxlovid metabolism were further verified in Cyp3a-null mice,which showed that the deficiency of CYP3A significantly suppressed the metabolism of NMV and RTV.Pregnane X receptor(PXR)is a ligand-dependent transcription factor that upregulates CYP3A4/5 expression.We next explored the impact of drug-and herb-mediated PXR activation on Paxlovid metabolism in a transgenic mouse model expressing human PXR and CYP3A4/5.We found that PXR activation increased CYP3A4/5 expression,accelerated NMV metabolism,and reduced the systemic exposure of NMV.In summary,our work demonstrated that PXR activation can cause drug interactions with Paxlovid,suggesting that PXR-activating drugs and herbs should be used cautiously in COVID-19 patients receiving Paxlovid. | Saifei Lei Alice Guo Jie Lu Qian Qi Aaron S.Devanathan Junjie Zhu Xiaochao Ma | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 10 | Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic显示文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction. | Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sugimura Masaaki Uno Yohei Takenobu Yuji Matsumaru Satoshi Yamada Ryuhei Kono Takuya Kanamaru Masafumi Morimoto Junichi Iida Vasu Saini Dileep Yavagal Saif Bushnaq Wenguo Huang Italo Linfante Jawad Kirmani David S Liebeskind Viktor Szeder Ruchir Shah Thomas G Devlin Lee Birnbaum Jun Luo Anchalee Churojana Hesham E Masoud Carlos Ynigo Lopez Brendan Steinfort Alice Ma Ameer E Hassan Amal Al Hashmi Mollie McDermott Maxim Mokin Alex Chebl Odysseas Kargiotis Georgios Tsivgoulis Jane G Morris Clifford J Eskey Jesse Thon Leticia Rebello Dorothea Altschul Oriana Cornett Varsha Singh Jeyaraj Pandian Anirudh Kulkarni Pablo M Lavados Veronica V Olavarria Kenichi Todo Yuki Yamamoto Gisele Sampaio Silva Serdar Geyik Jasmine Johann Sumeet Multani Artem Kaliaev Kazutaka Sonoda Hiroyuki Hashimoto Adel Alhazzani David Y Chung Stephan A Mayer Johanna T Fifi Michael D Hill Hao Zhang Zhengzhou Yuan Xianjin Shang Alicia C Castonguay Rishi Gupta Tudor G Jovin Jean Raymond Osama O Zaidat Raul G Nogueira SVIN COVID-19 Registry,the Middle East North Africa Stroke and Interventional Neurotherapies Organization(MENA-SINO),Japanese Society of Vascular and Interventional Neurology Society(JVIN) | 2021 | Stroke & Vascular Neurology2021，6，4： | 0 |
| 11 | Patterns of floristic inventory and plant collections in Myanmar显示文摘Myanmar is one of the most biodiverse countries in the Asia-Pacific region due to a wide range of climatic and environmental heterogeneity.Floristic diversity in Myanmar is largely unknown,resulting in a lack of comprehensive conservation plans.We developed a database of higher plants in Myanmar derived from herbarium specimens and literature sources,and analyzed patterns of diversity inventories and collection inconsistencies,aiming to provide a baseline floristic data of Myanmar and act as a guide for future research efforts.We collected 1,329,354 records of 16,218 taxa.Results show that the collection densities at the township level was variable,with 5% of townships having no floristic collections.No ecoregion had an average collection density of greater than 1 specimen/km2and the lowest collection density was found in the Kayah-Karen Montane Rainforests,which covered 8% of Myanmar’s total area.The highest sampling densities were found in Mandalay Region,Chin State,and Yangon Region.Despite floristic collections over the past three centuries,knowledge of the distribution of the vast majority of plant taxa remained limited,particularly for gymnosperms,pteridophytes,and bryophytes.More botanical surveys and further analyses are needed to better describe Myanmar’s floristic diversity.An important strategy to promote knowledge of the biodiversity patterns in Myanmar is to improve the collection and digitalization of specimens and to strengthen cooperation among countries. | Thant Sin Aung Alice CHughes Phyo Kay Khine Bo Liu Xiao-Li Shen Ke-Ping Ma | 2023 | Plant Diversity2023，45，3： | 0 |
| 12 | Corrigendum to Patterns of floristic inventory and plant collections in Myanmar[Plant Divers.45(3)(2023)302-308]显示文摘1.Figure 2:Repeat title-Incorrect title:(A)Density of sampling per cell.(B)Density of sampling per ecoregion.Terrestrial ecoregions classified into(1)Chin Hills-Arakan Yoma Montane Forests(A)Density of sampling per cell.(B)Density of sampling per ecoregion.Terrestrial ecoregions classified into(1)Chin Hills-Arakan Yoma Montane Forests,(2)Eastern Himalayan Alpine Shrub And Meadows. | Thant Sin Aung Alice CHughes Phyo Kay Khine Bo Liu Xiao-Li Shen Ke-Ping Ma | 2023 | Plant Diversity2023，45，6： | 0 |
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