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| 1 | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis显示文摘Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication.However,these boundary layers can be damaged by shear,resulting in decreased lubrication.Here,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable lubrication.Moreover,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining lubrication.Furthermore,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication.Overall,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang | 2022 | Bioactive Materials2022，7，10： | 4 |
| 2 | Orofacial inflammatory pain affects the expression of MT1 and NADPH-d in rat caudal spinal trigeminal nucleus and trigeminal ganglion显示文摘Very little is known about the role of melatonin in the trigeminal system,including the function of melatonin receptor 1.In the present study,adult rats were injected with formaldehyde into the right vibrissae pad to establish a model of orofacial inflammatory pain.The distribution of melatonin receptor 1 and nicotinamide adenine dinucleotide phosphate diaphorase in the caudal spinal trigeminal nucleus and trigeminal ganglion was determined with immunohistochemistry and histochemistry.The results show that there are significant differences in melatonin receptor 1 expression and nicotinamide adenine dinucleotide phosphate diaphorase expression in the trigeminal ganglia and caudal spinal nucleus during the early stage of orofacial inflammatory pain.Our findings suggest that when melatonin receptor 1 expression in the caudal spinal nucleus is significantly reduced,melatonin's regulatory effect on pain is attenuated. | Fang Huang Hongwen He Wenguo Fan Yongliang Liu Hongyu Zhou Bin Cheng | 2013 | Neural Regeneration Research2013，8，32： | 4 |
| 3 | Age-dependent loss of cholinergic neurons in learning and memory-related brain regions and impaired learning in SAMP8 mice with trigeminal nerve damage显示文摘The tooth belongs to the trigeminal sensory pathway.Dental damage has been associated with impairments in the central nervous system that may be mediated by injury to the trigeminal nerve.In the present study,we investigated the effects of damage to the inferior alveolar nerve,an important peripheral nerve in the trigeminal sensory pathway,on learning and memory behaviors and structural changes in related brain regions,in a mouse model of Alzheimer's disease.Inferior alveolar nerve transection or sham surgery was performed in middle-aged(4-monthold) or elderly(7-month-old) senescence-accelerated mouse prone 8(SAMP8) mice.When the middle-aged mice reached 8 months(middle-aged group 1) or 11 months(middle-aged group 2),and the elderly group reached 11 months,step-down passive avoidance and Y-maze tests of learning and memory were performed,and the cholinergic system was examined in the hippocampus(Nissl staining and acetylcholinesterase histochemistry) and basal forebrain(choline acetyltransferase immunohistochemistry).In the elderly group,animals that underwent nerve transection had fewer pyramidal neurons in the hippocampal CA1 and CA3 regions,fewer cholinergic fibers in the CA1 and dentate gyrus,and fewer cholinergic neurons in the medial septal nucleus and vertical limb of the diagonal band,compared with sham-operated animals,as well as showing impairments in learning and memory.Conversely,no significant differences in histology or behavior were observed between middle-aged group 1 or group 2 transected mice and age-matched sham-operated mice.The present findings suggest that trigeminal nerve damage in old age,but not middle age,can induce degeneration of the septal-hippocampal cholinergic system and loss of hippocampal pyramidal neurons,and ultimately impair learning ability.Our results highlight the importance of active treatment of trigeminal nerve damage in elderly patients and those with Alzheimer's disease,and indicate that tooth extraction should be avoided in these populations. | Yifan He Jihong Zhu Fang Huang Liu Qin Wenguo Fan Hongwen He | 2014 | Neural Regeneration Research2014，9，22： | 2 |
| 4 | Distance-controllable and direction-steerable opto-conveyor for targeting delivery显示文摘Opto-conveyors have attracted widespread interest in various fields because of their non-invasive and non-contact delivery of micro/nanoparticles.However,the flexible control of the delivery distance and the dynamic steering of the delivery direction,although very desirable in all-optical manipulation,have not yet been achieved by optoconveyors.Here,using a simple and cost-effective scheme of an elliptically focused laser beam obliquely irradiated on a substrate,a direction-steerable and distance-controllable opto-conveyor for the targeting delivery of microparticles is implemented.Theoretically,in the proposed scheme of the opto-conveyor,the transverse and longitudinal resultant forces of the optical gradient force and the optical scattering force result in the transverse confinement and the longitudinal transportation of microparticles,respectively.In this study,it is experimentally shown that the proposed opto-conveyor is capable of realizing the targeting delivery for microparticles.Additionally,the delivery distance of microparticles can be flexibly and precisely controlled by simply adjusting the irradiation time.By simply rotating the cylindrical lens,the proposed opto-conveyor is capable of steering the delivery direction flexibly within a large range of azimuthal angles,from-75°to 75°.This study also successfully demonstrated the real-time dynamic steering of the delivery direction from-45°to 45°with the dynamical rotation of the cylindrical lens.Owing to its simplicity,flexibility,and controllability,the proposed method is capable of creating new opportunities in bioassays as well as in drug delivery. | Zhen Che Wenguo Zhu Yaoming Huang Yu Zhang Linqing Zhuo Pengpeng Fan Zhibin Li Huadan Zheng Wenjin Long Wentao Qiu Yunhan Luo Jun Zhang Jinghua Ge Jianhui Yu Zhe Chen | 2020 | Photonics Research2020，8，7： | 1 |
| 5 | Resonance-assisted light–control–light characteristics of SnS_2 on a microfiber knot resonator with fast response显示文摘An all-optical light–control–light functionality with the structure of a microfiber knot resonator (MKR) coated with tin disulfide (SnS_2) nanosheets is experimentally demonstrated. The evanescent light in the MKR [with a resonance Q of ~59,000 and an extinction ratio (ER) of ~26 dB] is exploited to enhance light–matter interaction by coating a two-dimensional material SnS_2 nanosheet onto it. Thanks to the enhanced light–matter interaction and the strong absorption property of SnS_2, the transmitted optical power can be tuned quasi-linearly with an external violet pump light power, where a transmitted optical power variation rate ΔT with respect to the violet light power of ~0.22 dB∕mW is obtained. In addition, the MKR structure possessing multiple resonances enables a direct experimental demonstration of the relationship between resonance properties (such as Q and ER), and the obtained ΔT variation rate with respect to the violet light power. It verifies experimentally that a higher resonance Q and a larger ER can lead to a higher ΔT variation rate. In terms of the operating speed, this device runs as fast as ~3.2 ms. This kind of all-optical light–control–light functional structure may find applications in future all-optical circuitry, handheld fiber sensors, etc. | HUIHUI LU ZHONGMIN WANG ZHIJIN HUANG JUN TAO HANQING XIONG WENTAO QIU HEYUAN GUAN HUAZHUO DONG JIANGLI DONG WENGUO ZHU JIANHUI YU YONGCHUN ZHONG YUNHAN LUO JUN ZHANG ZHE CHEN | 2018 | Photonics Research2018，6，12： | 0 |
| 6 | Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic显示文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction. | Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sugimura Masaaki Uno Yohei Takenobu Yuji Matsumaru Satoshi Yamada Ryuhei Kono Takuya Kanamaru Masafumi Morimoto Junichi Iida Vasu Saini Dileep Yavagal Saif Bushnaq Wenguo Huang Italo Linfante Jawad Kirmani David S Liebeskind Viktor Szeder Ruchir Shah Thomas G Devlin Lee Birnbaum Jun Luo Anchalee Churojana Hesham E Masoud Carlos Ynigo Lopez Brendan Steinfort Alice Ma Ameer E Hassan Amal Al Hashmi Mollie McDermott Maxim Mokin Alex Chebl Odysseas Kargiotis Georgios Tsivgoulis Jane G Morris Clifford J Eskey Jesse Thon Leticia Rebello Dorothea Altschul Oriana Cornett Varsha Singh Jeyaraj Pandian Anirudh Kulkarni Pablo M Lavados Veronica V Olavarria Kenichi Todo Yuki Yamamoto Gisele Sampaio Silva Serdar Geyik Jasmine Johann Sumeet Multani Artem Kaliaev Kazutaka Sonoda Hiroyuki Hashimoto Adel Alhazzani David Y Chung Stephan A Mayer Johanna T Fifi Michael D Hill Hao Zhang Zhengzhou Yuan Xianjin Shang Alicia C Castonguay Rishi Gupta Tudor G Jovin Jean Raymond Osama O Zaidat Raul G Nogueira SVIN COVID-19 Registry,the Middle East North Africa Stroke and Interventional Neurotherapies Organization(MENA-SINO),Japanese Society of Vascular and Interventional Neurology Society(JVIN) | 2021 | Stroke & Vascular Neurology2021，6，4： | 0 |
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