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| 1 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 2 | Extracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells: Implications in Acute Myocardial Infarction显示文摘 | Roland Schmidt Andreas Bültmann Martin Ungerer Nader Joghetaei ?zgür Bülbül Sven Thieme Triantafyllos Chavakis Bryan P. Toole Meinrad Gawaz Albert Sch?mig Andreas E. May | 2006 | Circulation2006，，6： | 1 |
| 3 | Boundary and elastohydrodynamic lubrication studies of glycerol aqueous solutions as green lubricants 显示文摘 | Mattias G Marcus B Roland L | 2014 | Tribology International2014，69，： | 1 |
| 4 | Fraquency and outcome of patients with nonthyroidal illness syndrome in a medical intensive care unit显示文摘 | Katharina Plikat Julia L Roland B | 2007 | Metabolism2007，，56： | 1 |
| 5 | Confined placental mosaicism in CVS and pregnancy outcome显示文摘 | Roland B Lynch L Berkowitz G | 1994 | Prenat Diagn1994，14，： | 1 |
| 6 | Anatomical distribution of prolactin-releasing peptide and its receptor suggests additional functions in the central nervous system and periphery显示文摘 | ROLAND B L SUTTON S W WILSON S J | 1999 | Endocrinology1999，140，12： | 1 |
| 7 | Cognitive stimulation in brainstorming显示文摘 | Paulus P B Roland E J | 2000 | Journal of Personality and Social Psychology2000，79，： | 1 |
| 8 | Antimicrobial resistance and resistance gene determinants in clinical Escheriehia coli from different animal species in Switzerland显示文摘 | Roland L Peter K Patrick B | 2003 | Veterinary Mierobiol2003，91，： | 1 |
| 9 | Single - dose, extendedrelease epidural morphine(DepoDur)compared to con- ventional epidural morphine for post - cesarean pain 显示文摘 | Carvalho B Roland L M Chu L F | 2007 | Anesth Analg2007，105，1： | 1 |
| 10 | Effect of formulation and process variables on the formation of chitosan-gelatin coacervates 显示文摘 | Carmen R L Roland B | 1996 | International Journal of Pharmaceutics1996，135，： | 1 |
| 11 | Anatomical Distribution of Prolactin - Releasing Peptide and its Receptor Suggests Additional Functions in the Central Nervous System and Periphery 显示文摘 | Roland B L Sutton S W Wilson S J | 1999 | Endocrinology1999，140，12： | 1 |
| 12 | Development of a Combined Sex Pheromone-based Monitoring System for Malacosoma disstria (Lepidoptera:Lasoicampidae) and Choristoneura conflictana (Lepidoptera:Tortricidae)显示文摘 | JONES B C ROLAND J EVENDEN M L | 2009 | Environmental Entomology2009，38，2： | 1 |
| 13 | HIV infected liver and kidney transplant recipients: 1 and 3 year outcomes显示文摘 | Roland ME Barin B Carlson L | 2008 | Am J Transplant2008，8，2： | 1 |
| 14 | Emergence of group A Streptococcus strains with different mechanisms of macrolide resistance显示文摘 | Edouard B Roland L | 2002 | Antimicrobial Agents and Chemotherapy2002，46，5： | 1 |
| 15 | Antimicrobial resistance and resis- tance gene determinants in clinical Escherichia coli from differ- ent animal species in Switzerland 显示文摘 | Roland L Peter K Patrick B | 2003 | Vet Microbiol2003，91，： | 1 |
| 16 | Local origins of some GABA ergic projections to the paraventricular and supraoptic nuclei of the hypothalamus of the rat显示文摘 | Roland B L Sawchenko P E | 1993 | Comp Neurol1993，332，： | 1 |
| 17 | Cloning and functional expression of the human histamine H3 receptor 显示文摘 | Lovenberg T W Roland B L Wilson S J | 1999 | Mol Pharmacol1999，55，6： | 1 |
| 18 | Analysis of tetraploid elymus species using wheat microsatellite markers and RAPDmarkers显示文摘 | SUN G L BJOM S ROLAND V B | 1998 | Genome1998，40，： | 1 |
| 19 | Amino terminal pro-brain natriuretic peptide, renal function, and outcomes in acute heart failure redefining the cardiorenal interaction? 显示文摘 | ROLAND R J JAMES L J AARON L B | 2006 | JACC2006，48，： | 1 |
| 20 | Emergence of group A Streptococcus strains with different echanisms of macrolide resistance显示文摘 | Edouard B Roland L | 2002 | Antimicrobial Agent s and Chemotherapy2002，46，5： | 1 |
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