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| 1 | Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010显示文摘Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes.Methods: Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves(Spain) from 1990 to 2010,based on five variables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature.Results: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption.Conclusion: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulative tobacco smoke load. | Alberto Caballero Vázquez Ana Dolores Romero Ortiz Jose Manuel González de Vega San Román Raimundo García del Moral Bernardino Alcázar Navarrete | 2018 | 中国肺癌杂志2018，21，1： | 17 |
| 2 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 3 | Plant Growth-Promoting Traits in Rhizobacteria of Heavy Metal-Resistant Plants and Their Effects on Brassica nigra Seed Germination显示文摘Phytoremediation is an emerging technology that uses plants and their associated microbes to clean up pollutants from the soil, water, and air. In order to select the plant growth-promoting rhizobacteria(PGPR) for phytoremediation of heavy metal contamination, 60 bacterial strains were isolated from the rhizosphere of two endemic plants, Prosopis laevigata and Spharealcea angustifolia, in a heavy metal-contaminated zone in Mexico. These rhizobacterial strains were characterized for the growth at different pH and salinity, extracellular enzyme production, solubilization of phosphate, heavy metal resistance, and plant growth-promoting(PGP) traits, including production of siderophores and indol-3-acetic acid(IAA). Overall, the obtained rhizobacteria presented multiple PGP traits. These rhizobacteria were also resistant to high levels of heavy metals(including As as a metalloid)(up to 480 mmol L(-1)As(V), 24 mmol L(-1)Pb(Ⅱ), 21 mmol L(-1)Cu(Ⅱ), and 4.5 mmol L(-1)Zn(Ⅱ)). Seven rhizobacterial strains with the best PGP traits were identified as members of Alcaligenes, Bacillus, Curtobacterium, and Microbacterium, and were selected for further bioassay.The inoculation of Brassica nigra seeds with Microbacterium sp. CE3R2, Microbacterium sp. NE1R5, Curtobacterium sp. NM1R1,and Microbacterium sp. NM3E9 facilitated the root development; they significantly improved the B. nigra seed germination and root growth in the presence of heavy metals such as 2.2 mmol L(-1)Zn(Ⅱ). The rhizobacterial strains isolated in the present study had the potential to be used as efficient bioinoculants in phytorremediation of soils contaminated with multiple heavy metals. | Brenda ROMN-PONCE Diana Miryel REZA-VZQUEZ Sonia GUTIRREZ-PAREDES María de Jesús DE HARO-CRUZ Jessica MALDONADO-HERNNDEZ Yanely BAHENA-OSORIO Paulina ESTRADA-DE LOS SANTOS En Tao WANG María Soledad VSQUEZ-MURRIETA | 2017 | Pedosphere2017，27，3： | 4 |
| 4 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 5 | Density-dependentliquid nitromethane decomposition: molecular dynamics simula-tions based on ReaxFF 显示文摘 | Rom N Zybin S V van Duin ACT | 2011 | journal of Physical Chemistry A2011，115，10： | 1 |
| 6 | Does opening a milk bank in a neonatal unit change infant feeding practices? A before and after study显示文摘 | Utrera Torres MI Medina López C Vázquez Román S | 2010 | IntBreastfeed2010，8，5： | 1 |
| 7 | Assessment af energy distri- bution losses for increasing penetration of distributed generation显示文摘 | Quezada V H M Abbad J R Rom'an T G S | 2006 | IEEE Transactions on Power Systems2006，21，2： | 1 |
| 8 | Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma显示文摘 | HECK S ROM J THEWES V | | 0，，12： | 1 |
| 9 | Density-dependent liquid nitromethane decomposition: molecular dynamics simula- tions based on ReaxFF 显示文摘 | Rom N Zybin S V van Duin A C T | 2011 | The Journal of Physical Chemistry A2011，115，10： | 1 |
| 10 | Biogenic amines in winesInfluence of oenological factors显示文摘 | Marques A P Leit觔o M C Rom觔o M V S | 2008 | Food Chemistry2008，107，2： | 1 |
| 11 | Radiographic technical quality of root canal treatment per-formed ex vivo by dental students at Valencia University Medi-caland Dental School,Spain显示文摘 | Román-Richon S Faus-Matoses V Alegre-Domingo T | | 0，，： | 1 |
| 12 | Membrane elastic properties and cell function显示文摘 | Pontes B Ayala Y Fonseca ACC Rom?o LF Amaral RF Salgado LT Lima FR Farina M Viana NB Moura-Neto V Nussenzveig HM | | 0，，： | 1 |
| 13 | Assessment of energy distribution losses for increasing penetration of distribut- ed generation显示文摘 | QUEZADA V H M ABBAD J R ROM'AN T G S | 2006 | IEEE Transactions on Power Systems2006，21，2： | 1 |
| 14 | Early weaning stimulates intestinal brush border enzyme activities in piglets,mainly at posttranscriptional level显示文摘 | Marion J Petersen Y M Romé V | 2005 | J Pediatr Gastroenterol Nutr2005，41，： | 1 |
| 15 | Endothelial dysfunction inHIV infection--the role of circulating endothelial cells, microparticles,endothelial progenitor cells and macrophages显示文摘 | López M San Román J Estrada V | 2012 | AIDS Rev2012，14，4： | 1 |
| 16 | Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma显示文摘 | Heck S Rom J Thewes V | 2009 | Cancer Res2009，69，12： | 1 |
| 17 | Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts显示文摘 | Durand SH Flacher V Roméas A | 2006 | J Immunol2006，176，5： | 1 |
| 18 | Expression of a functional inducible nitric oxide synthase in hairy cell leulem ia and ESKOL cell line 显示文摘 | Rom an V Zhan H Foumeau JM | 2000 | Leukemia2000，14，4： | 1 |
| 19 | Does Role Stress Predict Burnout Over Time among Health Care Professionals? 显示文摘 | PEIRO J M GONZALEZ - ROM/k V TORDERA N | 2001 | Psychology Health2001，16，5： | 1 |
| 20 | Characterization of Ni-Mg-Al mixed oxides and their catalytic activity in oxidative dehydrogenation of n-butane and propene显示文摘 | HOLGADO M J RIVES V SAN ROM(A)N M S | | 0，，： | 1 |
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