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| 1 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | Change in ecosystem service values in the San Antonio area, Texas显示文摘 | Urs P Kreuter Heather G Harris Marty D Matlock Ronald E Lacey | 2001 | Ecological Economics2001，，3： | 3 |
| 3 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 4 | Liver Resection for Metastatic Colorectal Cancer in Patients with Concurrent Extrahepatic Disease: Results in 127 Patients Treated at a Single Center显示文摘 | Darren R. Carpizo PhD Chandrakanth Are MD William Jarnagin MD Ronald DeMatteo MD Yuman Fong MD Mithat G?nen PhD Leslie Blumgart MD Michael D'Angelica MD | 2009 | Annals of Surgical Oncology2009，，8： | 2 |
| 5 | Preoperative CA 19-9 and the Yield of Staging Laparoscopy in Patients with Radiographically Resectable Pancreatic Adenocarcinoma显示文摘 | Shishir K. Maithel MD Stephen Maloney MD Corrine Winston MD Mithat G?nen PhD Michael I. D'Angelica MD Ronald P. DeMatteo MD William R. Jarnagin MD Murray F. Brennan MD Peter J. Allen MD | 2008 | Annals of Surgical Oncology2008，，12： | 2 |
| 6 | Change in ecosystem service values in the San Antonio area, Texas显示文摘 | Urs P Kreuter Heather G Harris Marty D Matlock Ronald E Lacey | 2001 | Ecological Economics2001，，3： | 2 |
| 7 | Alfalfa yield and quality as influenced by establishment method显示文摘 | Michael D H Kenneth J M Ronald G | 2002 | Agronomy Journal2002，94，1： | 1 |
| 8 | Birth weight is inversely associated with incident coronary heart disease and stroke among individuals born in the 1950s:findings from the aberdeen children of the 1950s prospective cohort study显示文摘 | LAWLOR D A RONALDS G | 2005 | Circulation2005，6，10： | 1 |
| 9 | Structure and properties of pyruvate decarboxylase and site - directed mutagenesis of the Zymomonas mobilis enzyme显示文摘 | Judith M C Ronald G D | 1998 | Biochimica Biophysica Acta1998，1385，： | 1 |
| 10 | Prognostic Significance of Pathologic Nodal Status in Patients with Resected Pancreatic Cancer显示文摘 | Michael G. House Mithat G?nen William R. Jarnagin Michael D'Angelica Ronald P. DeMatteo Yuman Fong Murray F. Brennan Peter J. Allen | 2007 | Journal of Gastrointestinal Surgery2007，，11： | 1 |
| 11 | Efeets of initial ischemia/reperfusion injury on the transplanted kidney 显示文摘 | Nicholas L T Ronald D G | 1997 | Transplantation1997，64，： | 1 |
| 12 | Phenylpropanoid Glycosides from Stellero Chamaejasme显示文摘 | Jin C D Ronald G M Mohsen Daneshtalab | 1999 | Phytochemistry1999，50，： | 1 |
| 13 | Real-time seam tracking forrobotic laser welding using trajectory-based control显示文摘 | Menno D G Ronald A Ben J | 2010 | ControlEngineering Practice2010，18，8： | 1 |
| 14 | Evaluation of continuous mesophilic,thermophilic and temperature phased anaerobic digestion of microwaved activated sludge显示文摘 | Coelho N G Ronald L D Kevin J K | 2011 | Water Research2011，，45： | 1 |
| 15 | The Kasai portoenterostomy for biliary atresia: a review of a 27-year experience with 81 patients显示文摘 | Barbara E Wildhaber Arnold G Coran Robert A Drongowski Ronald B Hirschl James D Geiger Joseph L Lelli Daniel H Teitelbaum | 2003 | Journal of Pediatric Surgery2003，，10： | 1 |
| 16 | Effects of high temperature treatments on seed yield and self incompatibility in chrysanthemum 显示文摘 | Ronald W G Ascher P D | 1975 | Euphytica1975，24，： | 1 |
| 17 | Structure of a secoisolaricir-esinol di- ester from Salvia plebeia seed 显示文摘 | Richard G P Ronald D P | 1976 | Phytochem1976，15，12： | 1 |
| 18 | Antiretroviral prophylaxis for HIV prevention in heterosexual men and women 显示文摘 | Baeten JM Donnell D Ndase P Mugo NR Campbell JD Wangisi J Tappero JW Bukusi EA Cohen CR Katabira E Ronald A Tumwesigye E Were E Fife KH Kiarie J Farquhar C John-Stewart G Kakia A Odoyo J Mucungu- zi A Nakku-Joloba E Twesigye R Ngure K Apaka C Tamooh H Gabona F Mujugira A Panteleeff D Thomas KK Kidoguchi L Krows M Revall J Morrison S Haugen H Emmanuel-Ogier M Ondrejcek L Coombs RW Fren- kel L Hendrix C Bumpus NN Bangsberg D Haberer JE Stevens WS Lingappa JR Celum C Partners PrEP Study Team | 2012 | N Engl J Med2012，367，5： | 1 |
| 19 | MERRA: NASA’s Modern-Era Retrospective Analysis for Research and Applications显示文摘 | Rienecker Michele M Suarez Max J Gelaro Ronald Todling Ricardo Bacmeister Julio Liu Emily Bosilovich Michael G Schubert Siegfried D Takacs Lawrence Kim Gi-Kong Bloom Stephen Chen Junye Collins Douglas Conaty Austin Da Silva Arlindo Gu Wei | 2011 | Journal of Climate2011，，14： | 1 |
| 20 | Physician- older patient communication about cancer 显示文摘 | Michele G Greene Ronald D | 2003 | Patient Education and Counseling2003，50，1： | 1 |
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