|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Investigation on quality of cubic GaN/GaAs(100) by double-crystal X-ray diffraction显示文摘 | Dapeng Xu Rutian Wang Hui Yang Lianxi Zheng Jianbin Li Lihong Duan Ronghan Wu | 1999 | Science in China Series A: Mathematics1999，，5： | 1 |
| 2 | Hyaluronic acid-curcumin conjugate suppresses the fibrotic functions of myofibroblasts from contractive joint by the PTGER2 demethylation显示文摘Joint contracture is a fibrotic complication induced by joint immobilization and trauma,which is characterized as excessive myofibroblast proliferation in joint capsule.The treatments of joint contracture are unsatisfied and patients are suffered from joint dysfunction.Our previous study has shown that curcumin can inhibit myofibroblast proliferation in vitro,but the major challenge is the low aqueous solubility and biological activity of curcumin.In this study,hyaluronic acid-curcumin(HA-Cur)conjugate was synthesized to suppress myofibroblasts in joint contracture.Cells were isolated from the joint capsules of joint contracture patients and induced to active myofibroblasts by transforming growth factor-b(TGF-b).The anti-fibrotic function and mechanisms of HA-Cur were investigated by immunohistochemistry,reverse transcription-quantitative polymerase chain reaction(PCR),methylation-specific PCR,western blot,transwell migration assay and proliferation assay.Results showed that 30 lM HA-Cur significantly attenuated the fibrotic functions of myofibroblast in joint contracture in vitro by regulating the methylation of prostaglandin E receptor 2(PTGER2)and inhibiting TGF-b signaling.This may provide a mechanism for the treatment of joint contracture,and provide a molecular target PTGER2 for therapy during the pathogenesis of joint contracture. | Dongjie Yu Ze Zhuang Jianhua Ren Xuefeng Hu Zhe Wang Jieyu Zhang Yuansen Luo Kun Wang Ronghan He Yunbing Wang | 2019 | Regenerative Biomaterials2019，6，5： | 1 |
| 3 | Study on restraining frost growth at initial stage by hydrophobic coating and hygroscopic coating 显示文摘 | Cai Liang Wang Ronghan Hou Puxiu Zhang Xiaosong | 2011 | Energy and Buildings2011，43，： | 1 |
| 4 | Mineralization of calcium phosphate controlled by biomimetic selfassembled peptide monolayers via surface electrostatic potentials显示文摘The functions of acidic-rich domains in non-collagenous protein during biomineralization are thought to induce nucleation and control the growth of hydroxyapatite.The tripeptide Asp-Ser-Ser(DSS)repeats are the most common acidic-rich repeated unit in non-collagenous protein of dentin phosphoprotein,the functions of which have aroused extensive interests.In this study,biomimetic peptides(DSS)n(n=2 or 3)were designed and fabricated into self-assembled monolayers(SAMs)on Au(111)surface as biomimetic organic templates to regulate hydroxyapatite(HAp)mineralization in 1.5 simulated body fluid(1.5 SBF)at 37°C.The early mineralization processes and minerals deposited on the SAMs were characterized by X-ray diffraction,scanning electron microscope,and Fourier transform infrared spectroscopy analyses.The SAM-DSS9/DSS9G showed the highest capacity to induce HAp nucleation and growth,followed by SAM-DSS6/DSS6G,SAM-COOH,and SAMOH.The SAM-(DSS)n had more negative zeta potentials than SAM-COOH surface,indicating that DSS repeats contributed to the biomineralization,which not only provided strong affinity with Ca2+ions through direct electrostatic bonds,but more importantly influence surface electrostatic potentials of the assembled organic template for nucleation. | Shuo Wang Yongdong Yang Ronghan Wang Xiangdong Kong Xiumei Wang | 2020 | Bioactive Materials2020，5，2： | 0 |
| 5 | Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation显示文摘Cellular immunity mediated by CD8+T cells plays an indispensable role in bacterial and viral clearance and cancers.However,persistent antigen stimulation of CD8+T cells leads to an exhausted or dysfunctional cellular state characterized by the loss of effector function and high expression of inhibitory receptors during chronic viral infection and in tumors.Numerous studies have shown that glycogen synthase kinase 3(GSK3)controls the function and development of immune cells,but whether GSK3 affects CD8+T cells is not clearly elucidated.Here,we demonstrate that mice with deletion of Gsk3αand Gsk3βin activated CD8+T cells(DKO)exhibited decreased CTL differentiation and effector function during acute and chronic viral infection.In addition,DKO mice failed to control tumor growth due to the upregulated expression of inhibitory receptors and augmented T-cell exhaustion in tumor-infiltrating CD8+T cells.Strikingly,anti-PD-1 immunotherapy substantially restored tumor rejection in DKO mice.Mechanistically,GSK3 regulates T-cell exhaustion by suppressing TCR-induced nuclear import of NFAT,thereby in turn dampening NFAT-mediated exhaustion-related gene expression,including TOX/TOX2 and PD-1.Thus,we uncovered the molecular mechanisms underlying GSK3 regulation of CTL differentiation and T-cell exhaustion in anti-tumor immune responses. | Yubing Fu Jinjia Wang Chenfeng Liu Kunyu Liao Xianjun Gao Ronghan Tang Binbin Fan Yazhen Hong Nengming Xiao Changchun Xiao Wen-Hsien Liu | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 6 | Hsa_circ_0002137 stabled by LIN28B promotes osteosarcoma cell growth through the hsa-miR-1246/BCL2 axis显示文摘Circular RNAs(circRNAs)are a novel class of non-coding RNA that have recently shown to have huge capabilities in the regulation of gene expression at the posttranscriptional level.Growing evidence has indicated that circRNAs could serve as competing endogenous RNAs(ceRNAs)to sponge microRNAs(miRNAs)and suppress functions of targeted miRNAs.Osteosarcoma(OS)is the most common malignant primary bone cancer.Hsa_circ_0002137 is upregulated in OS.However,the role of hsa_circ_0002137 in OS remains unclear.Using miRNA pull-down assay,we showed that cir_0002137 sponged hsa-miR-1246,and BCL2 apoptosis regulator(BCL2)mRNA was a potential target of hsa-miR-1246 in human osteosarcoma(HOS)cells.Further,we found that hsa_cir_0002137 could enhance the expression of BCL2 hsa-miR-1246 and promote HOS cell growth through sponging hsa-miR-1246.Moreover,RNA binding protein immunoprecip itation(RIP)assay revealed that lin-28 homolog B(LIN28B)protein associated with hsa_circ_0002137,and LIN28B could increase hsa_circ_0002137 stability and thus accelerate OS cell growth.Our work was the first to study the functions of hsa_circ_0002137,has-miR-1246 and LIN28B in OS,and these results may provide novel therapeutic targets for OS treatment. | FEI ZHANG JIANZHONG LAI RONGHAN HE YI SHI KUN XU SHIHAI JIANG TANGZHAO LIANG WANYU ZHAO WEIDA REN LEI ZHU SONG JIN KUN WANG | 2022 | BIOCELL2022，46，3： | 0 |
| 7 | High energy density in ultra-thick and flexible electrodes enabled by designed conductive agent/binder composite显示文摘Thick electrodes can increase incorporation of active electrode materials by diminishing the proportion of inactive constituents,improving the overall energy density of batteries.However,thick electrodes fabricated using the conventional slurry casting approach frequently exhibit an exacerbated accumulation of carbon additives and binders on their surfaces,invariably leading to compromised electrochemical properties.In this study,we introduce a designed conductive agent/binder composite synthesized from carbon nanotube and polytetrafluoroethylene.This agent/binder composite facilitates production of dry-process-prepared ultra-thick electrodes endowed with a three-dimensional and uniformly distributed percolative architecture,ensuring superior electronic conductivity and remarkable mechanical resilience.Using this approach,ultra-thick LiCoO_(2)(LCO) electrodes demonstrated superior cycling performance and rate capabilities,registering an impressive loading capacity of up to 101.4 mg/cm^(2),signifying a 242% increase in battery energy density.In another analytical endeavor,time-of-flight secondary ion mass spectroscopy was used to clarify the distribution of cathode electrolyte interphase(CEI) in cycled LCO electrodes.The results provide unprecedented evidence explaining the intricate correlation between CEI generation and carbon distribution,highlighting the intrinsic advantages of the proposed dry-process approach in fine-tu ning the CEI,with excellent cycling performance in batteries equipped with ultra-thick electrodes. | Xiaoyu Shen Hailong Yu Liubin Ben Wenwu Zhao Qiyu Wang Guanjun Cen Ronghan Qiao Yida Wu Xuejie Huang | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员