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| 1 | Hsa_circ_0002137 stabled by LIN28B promotes osteosarcoma cell growth through the hsa-miR-1246/BCL2 axis显示文摘Circular RNAs(circRNAs)are a novel class of non-coding RNA that have recently shown to have huge capabilities in the regulation of gene expression at the posttranscriptional level.Growing evidence has indicated that circRNAs could serve as competing endogenous RNAs(ceRNAs)to sponge microRNAs(miRNAs)and suppress functions of targeted miRNAs.Osteosarcoma(OS)is the most common malignant primary bone cancer.Hsa_circ_0002137 is upregulated in OS.However,the role of hsa_circ_0002137 in OS remains unclear.Using miRNA pull-down assay,we showed that cir_0002137 sponged hsa-miR-1246,and BCL2 apoptosis regulator(BCL2)mRNA was a potential target of hsa-miR-1246 in human osteosarcoma(HOS)cells.Further,we found that hsa_cir_0002137 could enhance the expression of BCL2 hsa-miR-1246 and promote HOS cell growth through sponging hsa-miR-1246.Moreover,RNA binding protein immunoprecip itation(RIP)assay revealed that lin-28 homolog B(LIN28B)protein associated with hsa_circ_0002137,and LIN28B could increase hsa_circ_0002137 stability and thus accelerate OS cell growth.Our work was the first to study the functions of hsa_circ_0002137,has-miR-1246 and LIN28B in OS,and these results may provide novel therapeutic targets for OS treatment. | FEI ZHANG JIANZHONG LAI RONGHAN HE YI SHI KUN XU SHIHAI JIANG TANGZHAO LIANG WANYU ZHAO WEIDA REN LEI ZHU SONG JIN KUN WANG | 2022 | BIOCELL2022，46，3： | 0 |
| 2 | Configurable circular-polarization-dependent optoelectronic silent state for ultrahigh light ellipticity discrimination显示文摘Filterless light-ellipticity-sensitive optoelectronic response generally has low discrimination,thus severely hindering the development of monolithic polarization detectors.Here,we achieve a breakthrough based on a configurable circular-polarization-dependent optoelectronic silent state created by the superposition of two photoresponses with enantiomerically opposite ellipticity dependences.The zero photocurrent and the significantly suppressed noise of the optoelectronic silent state singularly enhance the circular polarization extinction ratio(CPER)and the sensitivity to light ellipticity perturbation.The CPER of our device approaches infinity by the traditional definition.The newly established CPER taking noise into account is 3-4 orders of magnitude higher than those of ordinary integrated circular polarization detectors,and it remains high in an expanded wavelength range.The noise equivalent light ellipticity difference goes below 0.009° Hz-1/2 at modulation frequencies above 1000 Hz by a light power of 281 uW.This scheme brings a leap in developing monolithic ultracompact circular polarization detectors. | Yonghao Bu Xiansong Ren Jing Zhou Zhenhan Zhang Jie Deng Hangyu Xu Runzhang Xie Tianxin Li Weida Hu Xia Guo Wei Lu Xiaoshuang Chen | 2023 | Light(Science & Applications)2023，12，8： | 0 |
| 3 | Structural basis of INTAC-regulated transcription显示文摘DearEditor,Eukaryotic transcription by RNA polymerase I(Pol I)is a strictly regulated process that involves the interplay of numerous factors.Promoter-proximal pausing is a regulatory mechanism that connects transcription initiation and productive elongation in metazoans(Core and Adelman,2019).Pol II forms a paused elongation complex(PEC)through binding of two transcriptional regulation factors DSIF and NELF(Vos et al.,2018).Following the duration of pausing,Pol II either proceeds into productive elongation or undergoes promoter-proximal premature transcription termination(PTT)(Kamieniarz-Gdula and Proudfoot,2019),which plays a decisive role in determining transcriptional outputs. | Hai Zheng Qianwei Jin Xinxin Wang Yilun Qi Weida Liu Yulei Ren Dan Zhao Fei Xavier Chen Jingdong Cheng Xizi Chen Yanhui Xu | 2023 | Protein & Cell2023，14，9： | 0 |
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