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| 1 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 2 | Hemodialysis access显示文摘 | Rose DA Sonaike E Hughes K | 2013 | Surg Clin North Am2013，93，4： | 1 |
| 3 | Hemodialysis access显示文摘 | Rose DA Sonaike E Hughes K | 2013 | Surg Clin North Am2013，93，4： | 1 |
| 4 | Structure of Golgi alpha-mannosidase Ⅱ:a target for inhibition of growth and metastasis of cancer cells显示文摘 | VAN DEN ELSEN JM KUNTZ DA ROSE DR | 2001 | EMBO J2001，20，12： | 1 |
| 5 | Rain splash soil erosion estimation in the presence of rock fragments显示文摘 | Jomaa S Barry DA Brovelli A Heng BCP Sander GC Parlange JY Rose CW | 2011 | Catena2011，92，： | 1 |
| 6 | Autoimmunity in myocarditis:models and mechanisms显示文摘 | Rose NR Herskowitz A Neumann DA | 1993 | Clin Immunol Immunopathol1993，68，： | 1 |
| 7 | Effects of environmental anoxia and different periods of reoxygenation on oxidative balance in gills of the estuarine crab Chasmagnathus granulata显示文摘 | Ubirajara O. de Oliveira Alex Sander da Rosa Araújo Adriane Belló-Klein Roselis S.M. da Silva Luiz Carlos Kucharski | 2004 | Comparative Biochemistry and Physiology Part B2004，，1： | 1 |
| 8 | Factors influencing length of stay in the intensive care unit显示文摘 | Gruenberg DA Shelton W Rose SL | 2006 | Am J Crit Care2006，15，5： | 1 |
| 9 | Relative efficacy of atorvastatin 80 nag and pravastatin 40 mg in achieving the dual goals of low-density lipoprotein cholesterol (70 mmol/L and C-reactive protein (2 mg/L, an analysis of the PROVE-IT TIMI- 22 trial显示文摘 | Ridker PM Morrow DA Rose LM | 2005 | J Am Coll Cardiol2005，45，10： | 1 |
| 10 | Sorting of GPl-anchored proteins to glycol- ipids-enriched membrane subdomains during transport to the apical cell surface显示文摘 | Brown DA Rose JK | 1992 | Cell1992，68，3： | 1 |
| 11 | Induction ofmultiple heart autoantibodies in mice with coxsackievirusB3- and cardiac myosin-induced autoimmune myocarditis显示文摘 | Neumann DA Rose NR Ansari AA | 1994 | J Immunol1994，152，1： | 1 |
| 12 | Robust Text Independent Speaker Identification Using Gaussian Mixture Speaker Models 显示文摘 | REYNOLDS DA ROSE RC | 1995 | IEEE Transactions on Speech and Audio Processing1995，3，1： | 1 |
| 13 | Virtual reality: an assistive technology in neurological rehahilitation显示文摘 | Rose FD Attree EA Johnson DA | 1996 | Curr Opin Neurol1996，9，6： | 1 |
| 14 | Virtual reality: an assistive technology in neurological rehabilitation显示文摘 | Rose FD Attree EA Johnson DA | 1996 | Curr Opin Neurol1996，9，6： | 1 |
| 15 | Immune modu- latory oligonucleotides in prevention of nasal allergen-in- duced Eustachian tube dysfunction in rats显示文摘 | Ebert-CS Jr Rose AS Blanks DA | 2007 | Otolar- yngology--Head and Neck Surgery2007，137，2： | 1 |
| 16 | Hemodialysis access显示文摘 | Rose DA Sonaike E Hughes K | 2013 | Surg Clin North Am2013，93，4： | 1 |
| 17 | Virtual enriched environments in paediatric neuropsychological rehabilitation following traumatic brain injury:Feasibility,benefits and challenges显示文摘 | Penn PR Rose FD Johnson DA | 2009 | Developmental Neurorehabilitation2009，12，1： | 1 |
| 18 | Oxidative stability of biodiesel from soybeanoil fatty acid ethyl esters显示文摘 | ROSELI AP FERRARI VANESSA DA SILVA OLIVEIRA ARDALLA SCABIO | 2005 | Scientia agricola2005，62，6： | 1 |
| 19 | Glucose- added dialysis fluid prevents asymptomatic hypoglycaemia in reg- ular haemodialysis 显示文摘 | Burmeister JE Scapini A Da Rose Mihersteiner D | 2007 | Nephrol Dial Transplant2007，22，4： | 1 |
| 20 | Nonlinear interference and unidirectional wave mixing in metamaterials显示文摘 | Rose A Huang Da Smith D R | 2013 | PHYSICAL REVIEW LETTERS2013，110，6： | 1 |
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