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| 1 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 2 | The effect of LUT and Cluster size on deep-submicron FPGA performance and density显示文摘 | Ahmed Elias Rose Jonathan | 2000 | IEEE Transations on Very Large Scale Integration(VLSI) Systems2000，12，3： | 1 |
| 3 | Architecture of field-programmable gate arrays:the effect of logic block functionality on area efficiency显示文摘 | Rose Jonathan Francis Robert J Lewis David | 1990 | IEEE Journal of Solid-State Circuits1990，25，5： | 1 |
| 4 | Speed and area trade-offs in Cluster-based FPGA architectures显示文摘 | Marquardt Alexander Betz Vaughn Rose Jonathan | 2000 | IEEE Transactions on VLSI Systems2000，8，2： | 1 |
| 5 | Flexibility of interconnection structures for field-programmable gate arrays显示文摘 | Rose Jonathan Brown Stephen | 1991 | IEEE Journal of Solid-State Circuits1991，26，3： | 1 |
| 6 | Measuring the gap between FP- GAs and ASICs 显示文摘 | Kuon Ian Rose Jonathan | 2007 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems2007，26，2： | 1 |
| 7 | Identification of benzofuran central cores for the inhibition of leukotriene A 4 hydrolase显示文摘 | Wendy Eccles Jonathan M. Blevitt Jamila N. Booker Christa C. Chrovian Shelby Crawford Aimee Rose de Leon Xiaohu Deng Anne M. Fourie Cheryl A. Grice Krystal Herman Lars Karlsson Aaron M. Kearney Alice Lee-Dutra Jimmy Liang Rosa Luna Dan Pippel Navin Rao Ja | 2012 | Bioorganic & Medicinal Chemistry Letters2012，，： | 1 |
| 8 | Community Preferences for the Allocation of Solid Organs for Transplantation: A Systematic Review显示文摘 | Allison Tong Kirsten Howard Stephen Jan Alan Cass John Rose Steven Chadban Richard D. Allen Jonathan C. Craig | 2010 | Transplantation2010，，7： | 1 |
| 9 | The Legal Profession in Medieval England:A History of Regulation显示文摘 | JONATHAN ROSE | 1998 | Syracuse Law Review1998，，48： | 1 |
| 10 | Brief Early Psychological Interventions Following Trauma: A Systematic Review of the Literature显示文摘 | Suzanna Rose Jonathan Bisson | 1998 | Journal of Traumatic Stress1998，，4： | 1 |
| 11 | Professional regulation显示文摘 | Jonathan Rose | 1983 | Law and Human Behavior (-)1983，，2： | 1 |
| 12 | 796: History of hypertension in pregnancy predicts hyperhomocysteinemia decades later显示文摘 | Wendy White Brian Brost Vesna Garovic Joshua Nitsche Jonathan O’Brien William Watson Carl Rose Norman Davies Kent Bailey Heather Wiste Stephen Turner | 2011 | American Journal of Obstetrics and Gynecology2011，，1： | 1 |
| 13 | Emission of Volatile Organic Compounds After Herbivory from Trifolium pratense (L.) Under Laboratory and Field Conditions显示文摘 | Rose N. Kigathi Sybille B. Unsicker Michael Reichelt Jürgen Kesselmeier Jonathan Gershenzon Wolfgang W. Weisser | 2009 | Journal of Chemical Ecology2009，，11： | 1 |
| 14 | Transcriptome-level microarray expression profiling implicates IGF-1 and Wnt signalling dysregulation in the pathogenesis of thyroid-associated orbitopathy显示文摘 | Daniel G Ezra Jonathan Krell Geoffrey E Rose Maryse Bailly Justin Stebbing Leandro Castellano | 2012 | Journal of Clinical Pathology2012，，： | 1 |
| 15 | Hemostatic Dressings for the First Responder:A Review显示文摘 | Marcus C Neuffer Jonathan McDivitt David Rose | 2004 | Military Medicine2004，169，9： | 1 |
| 16 | A systematic review of single-session psychological interventions ('debriefing')following trauma显示文摘 | Suzanna Rose Jonathan Bisson Simon Wessely | 2003 | Psychother Psychosom2003，，72： | 1 |
| 17 | Reduced Vitamin D in Acute Stroke显示文摘 | Kenneth E.S. Poole Nigel Loveridge Peter J. Barker David J. Halsall Collette Rose Jonathan Reeve Elizabeth A. Warburton | 2006 | Stroke2006，，1： | 1 |
| 18 | Results of a Retrospective Multicenter Trial of the Viatorr Expanded Polytetrafluoroethylene– covered Stent-Graft for Transjugular Intrahepatic Portosystemic Shunt Creation显示文摘 | Jean-Pierre M. Charon Fida H. Alaeddin Sheena A. Pimpalwar Dominic M. Fay Simon P. Olliff Ralph W. Jackson Richard D. Edwards Iain R. Robertson John D. Rose Jonathan G. Moss | 2004 | Journal of Vascular and Interventional Radiology2004，，11： | 1 |
| 19 | Prognostic importance of lymph node yield after curative resection of gastroenteropancreatic neuroendocrine tumours显示文摘BACKGROUND The prognostic significance of lymph nodes(LNs)metastases and the optimum number of LN yield in gastroenteropancreatic neuroendocrine tumours(GEP NETs)undergoing curative resection is still debatable.Many studies have demonstrated that cure rate for patients with GEP NETs can be improved by the resection of the primary tumour and regional lymphadenectomy AIM To evaluate the effect of lymph node(LN)status and yield on relapse-free survival(RFS)and overall survival(OS)in patients with resected GEP NETs.METHODS Data on patients who underwent curative resection for GEP NETs between January 2002 and March 2017 were analysed retrospectively.Grade 3 tumours(Ki67>20%)were excluded.Univariate Cox proportional hazard models were computed for RFS and OS and assessed alongside cut-point analysis to distinguish a suitable binary categorisation of total LNs retrieved associated with RFS.RESULTS A total of 217 patients were included in the study.The median age was 59 years(21-97 years)and 51%(n=111)were male.Primary tumour sites were small bowel(42%),pancreas(25%),appendix(18%),rectum(7%),colon(3%),gastric(2%),others(2%).Median follow up times for all patients were 41 mo(95%CI:36-51)and 71 mo(95%CI:63–76)for RFS and OS respectively;50 relapses and 35 deaths were reported.LNs were retrieved in 151 patients.Eight or more LNs were harvested in 106 patients and LN positivity reported in 114 patients.Three or more positive LNs were detected in 62 cases.The result of univariate analysis suggested perineural invasion(P=0.0023),LN positivity(P=0.033),LN retrieval of≥8(P=0.047)and localisation(P=0.0049)have a statistically significant association with shorter RFS,but there was no effect of LN ratio on RFS:P=0.1 or OS:P=0.75.Tumour necrosis(P=0.021)and perineural invasion(P=0.016)were the only two variables significantly associated with worse OS.In the final multivariable analysis,localisation(pancreas HR=27.33,P=0.006,small bowel HR=32.44,P=0.005),and retrieval of≥8 LNs(HR=2.7,P=0.036)were independent prognostic factors for worse RFS.CONCLUSION An outcome-oriented approach to cut-point analysis can suggest a minimum number of adequate LNs to be harvested in patients with GEP NETs undergoing curative surgery.Removal of≥8 LNs is associated with increased risk of relapse,which could be due to high rates of LN positivity at the time of surgery.Given that localisation had a significant association with RFS,a prospective multicentre study is warranted with a clear direction on recommended surgical practice and follow-up guidance for GEP NETs. | Jaseela Chiramel Rose Almond Astrid Slagter Adeel Khan Xin Wang Kok Haw Jonathan Lim Melissa Frizziero Bipasha Chakrabarty Annamaria Minicozzi Angela Lamarca Wasat Mansoor Richard A Hubner Juan William Valle Mairéad Geraldine McNamara | 2020 | World Journal of Clinical Oncology2020，11，4： | 0 |
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