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| 1 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 2 | FoxM1: At the crossroads of ageing and cancer显示文摘 | Jamila Laoukili Marie Stahl René H. Medema | 2006 | BBA - Reviews on Cancer2006，，1： | 3 |
| 3 | Endothelin-1 Stimulates Cardiac Fibroblast Proliferation Through Activation of Protein Kinase C显示文摘 | Lucia Piacentini Mary Gray Norman Y Honbo Jamila Chentoufi Marina Bergman Joel S Karliner | 2000 | Journal of Molecular and Cellular Cardiology2000，，4： | 1 |
| 4 | Treatment of Highly Polluted Paper Mill Wwastewater by Solar Photocatalytic Oxidation with Synthesized Nano TiO2 显示文摘 | Ghaly Montaser Y Jamila Tarek S E1-Seesy Ibrahim E | 2011 | Chemical Engineering Journal2011，168，1： | 1 |
| 5 | Key role of sinusoidal endothelial cells in the triggering of liver regeneration 显示文摘 | Nicolas M Jamila F | 2011 | J Hepatol2011，55，2： | 1 |
| 6 | FoxMl is required for execution of the mitotic programme and chromosome stability 显示文摘 | Jamila L Matthijs R H Alexandra B | 2005 | Cell Biology2005，7，2： | 1 |
| 7 | Identification of benzofuran central cores for the inhibition of leukotriene A 4 hydrolase显示文摘 | Wendy Eccles Jonathan M. Blevitt Jamila N. Booker Christa C. Chrovian Shelby Crawford Aimee Rose de Leon Xiaohu Deng Anne M. Fourie Cheryl A. Grice Krystal Herman Lars Karlsson Aaron M. Kearney Alice Lee-Dutra Jimmy Liang Rosa Luna Dan Pippel Navin Rao Ja | 2012 | Bioorganic & Medicinal Chemistry Letters2012，，： | 1 |
| 8 | Physiological relationships among physical, sensory, and morphological attributes of texture in tomato fruits显示文摘 | JAMILA C MAR1E-FRANCXOISE D MARIE- GHISLAINE G | 2007 | Journal of Experimental Botany2007，58，8： | 1 |
| 9 | Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome显示文摘 | Loredan SN Jamila FN Jean-Charles F | 2007 | Clin Chem Lab Me(t2007，45，9： | 1 |
| 10 | Transgene Organisation in Potato After Particle Bombardment-mediated (co-)Transformation Using Plasmids and Gene Cassettes显示文摘 | Andrea Romano Krit Raemakers Jamila Bernardi Richard Visser Hans Mooibroek | 2003 | Transgenic Research2003，，4： | 1 |
| 11 | Transgene Organisation in Potato After Particle Bombardment-mediated (co-)Transformation Using Plasmids and Gene Cassettes显示文摘 | Andrea Romano Krit Raemakers Jamila Bernardi Richard Visser Hans Mooibroek | 2003 | Transgenic Research2003，，4： | 1 |
| 12 | Abdominal cocoon and adhesiolysis:a case report and a literature review显示文摘 | Hassan A T Jamila E M Nool A S | 2013 | Case Rep Gastrointest Med2013，2013，： | 1 |
| 13 | Phenol extraction of proteins for portcomic studies of recalcitrant plant tissues 显示文摘 | Mireille F Esther P Jamila C | 2007 | Methods in Molecular Biology2007，355，： | 1 |
| 14 | Electrospinning of polycarbonate nanofibers with solvent mixtures THF and DMF显示文摘 | Jamila Shawon Changmo Sung | 2004 | Journal of Materials Science2004，，14： | 1 |
| 15 | Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5显示文摘 | Eric B Loredan-Stefan N | 2004 | Biochem Biophys Res Commun2004，319，： | 1 |
| 16 | Human genetics of tuberculosis: a long and winding road显示文摘 | Laurent Abel Jamila El-Baghdadi Ahmed Aziz Bousfiha Jean-Laurent Casanova Erwin Schurr | 2014 | Philosophical Transactions of the Royal Society B: Biological Sciences . 2014 (1645)2014，，1645： | 1 |
| 17 | 显示文摘 | Jamila L Iric P Tom W | 2001 | Clin Invest2001，108，： | 1 |
| 18 | Actual incidence and long-term consequences of post-hepatectomy liver failure after hepatectomy for colorectal liver metastases显示文摘 | Eric Vibert Gabriella Pittau Maximilliano Gelli A. Sa Cunha Laure Jamot Jamila Faivre Carlos Castro Benitez Denis Castaing René Adam | 2013 | Surgery2013，，： | 1 |
| 19 | Phenol extraction of proteins for proteomic studies of recalcitrant plant tissues显示文摘 | Mireille F Esther P Jamila C | 2008 | proteomics handbook2008，，： | 1 |
| 20 | Prevalence and Fac- tors Associated to Low Back Pain among Hospital Staff显示文摘 | Bejia I Younes M Jamila H B | 2005 | Joint Bone Spine2005，72，3： | 1 |
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