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| 1 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 2 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 3 | Sequential feeding of whole wheat to growing broiler chickens 显示文摘 | Rose S P Fielden M Foote W R | 1995 | Br Poult Sci1995，36，： | 1 |
| 4 | The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages显示文摘 | Whiteman M Li L Rose P | | 0，，10： | 1 |
| 5 | Sulphur dioxide resistance in Saccharomyces cerevisiae and Saccharomycodes ludwigii显示文摘 | Stratford M Morgan P Rose A H | 1987 | Journal of General Microbiology1987，133，： | 1 |
| 6 | Reference reagents for prostate-specific antigen (PSA):establishment of the first international standards for free PSA and PSA (90 -10)显示文摘 | Rafferty B Rigsby P Rose M | 2000 | Clin Chem2000，46，9： | 1 |
| 7 | Comparison of C-reactive protein and Low-density Lipoprotein choLesterol Levels in the prediction of first cardiovascular events显示文摘 | Ridker P M Rifai N Rose L | 2002 | N Engl J Med2002，347，： | 1 |
| 8 | Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events 显示文摘 | RIDKER P M RIFAI N ROSE L | 2002 | N Engl J Med2002，347，： | 1 |
| 9 | Cardiovascular events in the postanesthesia care unit:contribution of risk factors显示文摘 | Rose D Cohen M Deboer P | 1996 | Anesthesiology1996，84，： | 1 |
| 10 | The effect of hydrogen sulfide donors on lipopolysaceharide-induced formation of inflammatory mediators inmacrophages显示文摘 | Whiteman M Li L Rose P | 2010 | Antioxid Redox Signal2010，12，10： | 1 |
| 11 | Return to work 5 years after liver transplantation显示文摘 | D Moyzes M Walter M Rose P Neuhaus B.F Klapp | 2001 | Transplantation Proceedings2001，，5： | 1 |
| 12 | Antibodies to ccocidia:detection by the enzyme linked immunosorbent assay(ELISA)显示文摘 | Rose M E Moekett P A | 1953 | Parasite Immunology1953，5，： | 1 |
| 13 | Bioactive S-alk(en)yl cyste-ine sulfoxide metabolites in the genus Allium:the chemistry of potential therapeutic agents显示文摘 | Rose P Whiteman M Moore P K | 2005 | Nat Prod Rep2005，22，3： | 1 |
| 14 | M apping of serotypespecific,im m unodom inantepitopes in the NS-4region ofhepatitisC virus(H CV):use oftype-specific peptidesto serologically differentiate infections with H CV types1,2,and3显示文摘 | Sim m onds P Rose KA Graham S | 1993 | J Clin M icrobiol1993，31，6： | 1 |
| 15 | Peripheral blood leucocyte response to coocidial infection: a comparison of the response in rats and chickens and its correlation with resistance to refection 显示文摘 | ROSE M E HESKETH P OGILVIE B M | 1979 | Parasitol1979，36，： | 1 |
| 16 | Reference reagents for pros tate-specifie antigen (PSA): establishment of the first interna tional standards for free PSA and PSA(90:10)显示文摘 | Rafferty B Rigsby P Rose M | 2000 | Clinical ehem istry2000，46，9： | 1 |
| 17 | Analytical procedures for the measurement of boron isotope compositions by ion microprobe in meteorites and mantle rocks显示文摘 | Chaussidon M Robert F Mangin D Hanon P Rose E F | 1997 | Geostand Newslett1997，21，1： | 1 |
| 18 | A Saccharomyces cerevisiae genomic plasimid bank based on a centromere containing shuttle vector显示文摘 | Rose M D Novick P Thomas J H | 1987 | Gene1987，60，： | 1 |
| 19 | Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium:the chemistry of potential therapeutic agents显示文摘 | Rose P Whiteman M Moore PK | 2005 | Nat Prod Rep2005，22，3： | 1 |
| 20 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
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